Surgical amniotic membrane transplantation after conjunctival and limbal tumor
            excision

Göktaş, Şeniz Engür; Katircioğlu, Yasemin A.; Çelik, Tuba; Örnek, Firdevs

doi:10.5935/0004-2749.20170059

Cited by 7 publications

(5 citation statements)

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“…When considering tumour recurrence in the usage of OMG, one has to consider the possibility that recurrence can occur underneath the graft. In such cases, due to the thickness of the graft, OMG could conceal a tumour and noticing tumour recurrence is delayed 27 28. In this study, we did not compare OMG with other, thinner tissues such as amniotic membrane and hence cannot comment on a possible delay in diagnosis.…”

Section: Discussionmentioning

confidence: 89%

“…Besides mucosal tissues, the amniotic membrane is an alternative tissue that can be used in the ocular reconstruction. The tissue has been used to cover defects after tumour excision15 27 28 but also in combination with oral mucosa grafting (OMG) in the treatment of severe symblephara 14. The use of amniotic membrane has the advantage of being less invasive and it has been suggested that due to the thinness of the membrane, monitoring tumour recurrence is facilitated 27 28…”

Section: Introductionmentioning

confidence: 99%

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Assessing full thickness oral mucosal grafting: complications and postoperative outcomes in a broad collective of patients

2020

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BackgroundConjunctival defects can be repaired with several mucosal tissues. The simplicity of harvesting oral mucosa and its wide availability makes it the preferred graft tissue for all indications requiring mucosal grafting. Through analysing the postsurgical outcomes and rate of revisions, this study explores the suitability of oral mucosa grafts, depending on the initial diagnosis.MethodsWe reviewed all the files of patients with a history of oral mucosal graft surgery, performed at our clinic between 2012 and 2018, focusing on complications and revision rates.ResultsIn total, we analysed 173 oral mucosa grafts in 131 patients. The most common initial diagnosis was tumour resection, followed by surgical complications, postenucleation socket syndrome, trauma and ocular surface disorders. Complication and revision rates depended highly on the initial diagnosis. Revision rates were highest if the initial diagnosis included ocular surface disorders or chemical trauma.ConclusionsOral mucosa grafting (OMG) is the most effective treatment for a wide range of ocular conditions involving conjunctival defects. Conjunctival defects that result from trauma or cicatricial surface diseases seem less suitable for OMG and may benefit from alternative graft tissue or treatment options.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Assessing full thickness oral mucosal grafting: complications and postoperative outcomes in a broad collective of patients

2020

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“…11,12 Recently, amniotic membrane transplantation has been frequently reported after excision of various conjunctival tumors, including primary acquired melanosis, nevus, malignant melanoma, squamous cell carcinoma, and papilloma. [13][14][15][16] In this method, most authors reported high success rates with few complications. Although the amniotic membrane is a useful tissue for ocular surface reconstruction, it has some considerable disadvantages.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Autografts for Ocular Surface Reconstruction after Conjunctival Nevus Excision

Uçar

2022

Cornea

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The aim of this study was to evaluate the clinical and therapeutic outcomes of the cases where we used conjunctival autografts with and without the Tenon fascia for ocular surface reconstruction after conjunctival nevus excision.Methods: This study included 63 eyes of 63 patients who underwent conjunctival nevus excision between January 2013 and December 2020. Although a Tenon-free conjunctival autograft was used in 32 eyes of 32 patients in group 1, a Tenon-containing conjunctival autograft was used in 31 eyes of 31 patients in group 2. The clinical and histopathological characteristics of the nevus, complete graft epithelization, cosmetic outcomes, and postoperative complications were evaluated.Results: Conjunctival autografts were harvested from the contralateral eye in 3 eyes (9.3%) in group 1 and 2 eyes (6.4%) in group 2 (P = 0.66). Postoperatively, the mean defect size at the harvest site was 5.3 6 1.4 mm in group 1 and 5.5 6 1.5 mm in group 2 (P = 0.47). Graft edema was observed in only 1 case (3.1%) in group 1 and 6 cases (19.3%) in group 2 (P = 0.04). Although a complete graft epithelization was observed in all eyes in group 1, fluorescein staining was present in 2 eyes (6.4%) in group 2 (P = 0.14). Cosmetically, retracting and shrinking grafts were absent in group 1, whereas group 2 had in 4 eyes (12.9%) (P = 0.03). Neither group had conjunctival scarring, symblepharon, eyelid cicatrization, dysmotility, or pannus at the donor site.Conclusions: Ocular surface reconstruction with a Tenon-free conjunctival autograft after conjunctival nevus excision provides excellent cosmetic and functional results without significant complications.

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“…These include scar formation, symblepharon, granuloma, and partial or complete limbal stem cell deficiency. 5 Hence, it is important to select an appropriate and reliable graft for ocular surface reconstruction in order to reduce the risk of these complications. The amniotic membrane is an excellent choice in restoring and reconstructing the ocular surface following large conjunctival lesion excision.…”

Section: Discussionmentioning

confidence: 99%

Successful surgical management of large conjunctival nevus in a 10-year-old child with resection and amniotic membrane transplantation

Tiong

Birapadian³

2020

Asian JO

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The purpose of this paper is to illustrate a case of large conjunctival nevus in a 10-year-old boy which was successfully treated with surgical excision and amniotic membrane transplant (AMT) reconstruction. The conjunctival nevus was initially noticed by the parents 1 year prior to presentation; they reported it had increased in size over the past 3 months. Slit-lamp examination revealed a pigmented conjunctival nevus measuring 5.5 mm vertically and 6.5 mm horizontally, with well-demarcated margins and presence of an intralesional cyst at the temporal bulbar conjunctiva, involving the limbus and encroaching onto the cornea. Complete resection of the conjunctival lesion and bulbar conjunctival reconstruction were performed. The histopathological examination showed conjunctival nevus. The wound healed well with vision of 6/6 and no recurrence. Surgical resection combined with AMT is a successful and an effective way to treat conjunctivalnevus.

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Surgical amniotic membrane transplantation after conjunctival and limbal tumor excision

Abstract: AMT was effective for reconstruction of tissue defect after excision and cryotherapy of limbal and conjunctival tumors. In most of these cases, complete healing was achieved with a smooth, stable, and translucent surface.

Cited by 7 publications

References 0 publications

Assessing full thickness oral mucosal grafting: complications and postoperative outcomes in a broad collective of patients

Assessing full thickness oral mucosal grafting: complications and postoperative outcomes in a broad collective of patients

Conjunctival Autografts for Ocular Surface Reconstruction after Conjunctival Nevus Excision

Successful surgical management of large conjunctival nevus in a 10-year-old child with resection and amniotic membrane transplantation

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