Large colloid drusen analyzed with structural en face optical coherence tomography

Abstract

Drusen are extracellular deposits between the basal lamina of the retinal pigment epithelium (RPE) and the inner collagenous layer of Bruch's membrane. Large colloid drusen (LCD) are located below the RPE and are characterized by multiple, large, dome-shaped RPE detachments, with marked attenuation of the ellipsoid zone overlaying the drusen. This report presents the structural en face optical coherence tomography (OCT) findings of LCD and relates them to findings from fluorescein and indocyanine green angiography. We describe the case of a 55-year-old woman who presented with the chief complaint of a 5-year history of progressively worsening vision. Her best-corrected visual acuities were 20/40 and 20/400 in the right eye and the left eye, respectively. Fundus examination showed large bilateral, symmetrical, sub-retinal, yellowish lesions compatible with LCD. We describe the structural en face OCT characteristics and angiographic findings from this patient.

Optical Coherence Tomography Angiography Study of Choroidal Neovascularization Associated With Early-Onset Drusen

“…11,16 On FA, mild hyperfluorescence with a progressive staining in the late phase was observed. 17 The late phase of ICGA showed the hyperfluorescent halo around a hypofluorescent spot, called the "donut shape," that was bordered by a thin hypofluorescent ring. 16 Case 1 was diagnosed as LCD in both eyes on the basis of the distinct features on blue fundus autofluorescence and ICGA.…”

Clear subretinal fluid in a case of non-neovascular early-onset drusen: Swept-source imaging evaluation

“…3,5,6 LCD are larger in volume and show a donut pattern on ICGA (hypofluorescent center with a halo of hyperfluorescence, bordered by a thin hypofluorescent ring). 7,8…”