Topographic outcomes after corneal collagen crosslinking in progressive
            keratoconus: 1-year follow-up

Tiveron, Mauro C; Pena, Camila Ribeiro Koch; Hida, Richard Y; Moreira, Luciane Bugmann; Branco, Felipe Roberto Exterhotter; Kara-Júnior, Newton

doi:10.5935/0004-2749.20170023

Cited by 11 publications

(7 citation statements)

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“…Natural course of topographic changes after CXL is important for proper visual rehabilitation. Better spectacle correction and contact lens tolerance following CXL was observed in our and similar studies [13,14,15]. In addition, it is of particular interest to evaluate treatment response after CXL at different time points.…”

Section: Discussionsupporting

confidence: 69%

“…This was associated with a significant improvement in UCDVA and CDVA. Other studies have also reported a decrease in K max while improving visual and refractive outcomes at 1 year after CXL procedure [8,11,13]. Natural course of topographic changes after CXL is important for proper visual rehabilitation.…”

Section: Discussionmentioning

confidence: 95%

“…The efficacy of CXL procedure in majority of studies is determined by comparing pre-and postoperative Kmax values. Thus, maximum keratometry parameter is currently the standard in evaluating the efficacy of CXL for progressive KC [11,12,13].…”

Section: Discussionmentioning

confidence: 99%

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Tomographic changes after corneal collagen cross-linking for progressive keratoconus - one-year follow-up study

Petrovic

Stanojlović

2022

Srp Arh Celok Lek

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Introduction/Objective. The aim of this study was to evaluate outcome of corneal collagen cross-linking (CXL) in patients with progressive keratoconus. Methods. This retrospective single-centered interventional study included 52 eyes of 41 patients who underwent epithelium-off CXL procedure at the age > 18 years. Corneal tomography data, uncorrected and best spectacle-corrected distant visual acuity (UDVA and CDVA, respectively) were analyzed at baseline and postoperatively over the initial 12 months period. In addition, the natural course of corneal tomographic changes were demonstrated at 1, 3, 6, 9 and 12 months after CXL procedure. Results. At one year mean UDVA improved significantly from 0.15 ? 0.22 (0,3min - log MAR - 0 max logMAR) at baseline to 0.06 ? 0.09 logarithm of minimum angle resolution (log MAR) (0,1min log MAR-0 max logMAR) (p = 0.024). Mean CDVA was 0.45 ? 0.39 0.45 ? 0.39 logMAR (0,8min log MAR- 0 max logMAR) at baseline and 0.06 ? 0.13 log MAR (1min logMAR-0 max logMAR) at 1-year (p = 0.039). Maximum keratometry showed a significant flattening of 1.36D ? 1.53D (p = 0.0032) at 1 year after CXL. Minimum keratometry significantly decreased with a mean change of 1.15 ? 1.20 (p = 0.011). Mean anterior and posterior best fit sphere (ABFS, PBFS) remained stable during the entire follow up period. Mean reduction of corneal thickness after CXL was 47 ? 61?m (p = 0.003). At one year, 29 (56%) eyes showed K max regression; 22 (53%), stabilization; and 1 (2%), progression. Spearman correlation coefficients were calculated to assess the correlation between difference in preoperative corneal thickness, in PE CT and MCT, ?CT (PE CT-min CT) and radius difference ?r (r1-r2). Spearman rs > 0.3 proved statistical significance and correlation. Conclusion. In our study CXL effectively prevented progression of keratoconus in 98 % of eyes at 1 year, while improving visual acuity. The effect of CXL can be evaluated at the earliest after six months; at that time stability of corneal shape was provided following CXL procedure. The main limitation of this study is small number of patients included.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 95%

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Tomographic changes after corneal collagen cross-linking for progressive keratoconus - one-year follow-up study

Petrovic

Stanojlović

2022

Srp Arh Celok Lek

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“…[ 16 27 ] A meta-analysis also reported a significant improvement in the visual acuity for keratoconus patients at 12 months after CXL. [ 28 ] In the Tiveron study,[ 29 ] the visual acuity decreased significantly 12 months after CXL in patients with keratoconus. A significant improvement in the visual acuity after CXL surgery in keratoconus patients has been reported in other studies.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of changes in corneal volume, volume and angle of anterior chamber in keratoconus patients using Pentacam after CXL

Farrahi

Ostadian²,

Nickkhah³

et al. 2021

J Family Med Prim Care

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Introduction and Objective: Corneal collagen cross-linking (CXL) with riboflavin and ultraviolet-A (UVA) is a new technique of mechanical stability of the cornea and prevention of keratoconus progression. The present study aimed at the evaluation of the changes in the corneal volume (CV), volume, and the angle of anterior chamber in keratoconus patients using the Pentacam after CXL. Methods: This prospective study was performed on 48 eyes of 24 patients (including 12 men, 17–33 years old) with progressive keratoconus undergoing CXL treatment at collagen cross-linking Imam Khomeini Hospital in Ahvaz in 2019. The CV (CV) and anterior chamber parameters such as anterior chamber volume (ACV) and anterior chamber angle (ACA) were measured using the Pentacam before CXL and at 6 and 12 months after CXL. Also, all of the patients were evaluated in terms of best-corrected visual acuity (BCVA), during the follow-up. Results: The pre-CXL values of BCVA was significantly lower than the post-CXL values in 6 and 12 months (0.18 ± 0.11, 0.15 ± 0.10, and 0.11 ± 0.10, respectively, P < 0.0001). In general, there was a significant improvement in the BCVA ( P < 0.0001), a significant decrease in the CV ( P = 0.001), and a significant increase in the ACV ( P < 0.0001), and angle ( P < 0.0001) 6 and 12 months after CXL. Conclusion: It seems that CXL has a positive effect on the anterior chamber parameters (ACV and ACA) and CV after 6 months and 1 year in the treatment of keratoconus patients. In addition, the visual acuity improves after CXL. Finally, further studies with a higher sample size and longer follow-up periods are recommended.

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“… 13 In a Brazilian research, Kmax values were reduced by 0.68D following corneal cross-linkage in all 75 patients after three months and 0.87D after one year of therapy. 14 Another research in the Netherlands found that following corneal cross-linkage treatment, Kmax was reduced by 1D in 102 eyes in 79 patients. 15 In addition, a research in Egypt found that corneal cross-linkage treatment reduced Kmax by 1.57D in 40 keratoconus patients.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of Corneal Topographical Kmax readings 3 months after Corneal Cross Linkage in Keratoconus patients

Sangah¹,

Kumari²,

Mumtaz³

et al. 2022

Journal of Community Hospital Internal Medicine Perspectives

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Background and objective Collagen protein, which is abundant in the cornea and has a triple helix form, may be found in almost every tissue matrix in the body. Natural cross connections between monomers provide the robustness of the helical protein structure. Wollensak and his colleagues developed the Dresden Protocol, a keratoconus treatment based on Corneal Cross-Linkage. We aimed to analyse and present the findings in individuals with progressive keratoconus using topographic and refractive results after corneal collagen crosslinking treatment (CXL) (KC) after 3 months. Methods The study comprises a total of 100 patients who were diagnosed with progressive KC and who underwent CXL between 2021 and 2022 at KRL Hospital Islamabad, Pakistan. All eyes in this study had a preoperative topography within 1 month before CXL treatment and the follow-ups were conducted at 3 months interval. Results In our investigation, 100 patients were added. The average age was 24.74 years. 77% of the patients were between the ages of 12 and 25 years, while 23% were between the ages of 26 and 50 years. In our survey, males made up 84% of the population, while females made up only 16%. The right eye was afflicted in 60% of cases, whereas the left eye was impacted in 40% of the population. Grade 2 Keratoconus affected 42% of patients, whereas Grade 1 Keratoconus affected 18%. Our findings were skewed toward men and the 12–25 age group, however in our recent study, we discovered considerable KC stability 3 months after CXL. Conclusion Keratometric readings and visual acuity were stabilised or improved with CXL treatment. Keratoconus stability can be reached 3 months following the treatment, according to our findings.

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Topographic outcomes after corneal collagen crosslinking in progressive keratoconus: 1-year follow-up

Abstract: CXL promoted stabilization or improvement of keratometric values and visual acuity. We found that keratoconus apex stability may be achieved 3 months after the procedure. There was no significant difference in keratometric and refractive values measured between male and female patients.

Cited by 11 publications

References 0 publications

Tomographic changes after corneal collagen cross-linking for progressive keratoconus - one-year follow-up study

Tomographic changes after corneal collagen cross-linking for progressive keratoconus - one-year follow-up study

Evaluation of changes in corneal volume, volume and angle of anterior chamber in keratoconus patients using Pentacam after CXL

Outcomes of Corneal Topographical Kmax readings 3 months after Corneal Cross Linkage in Keratoconus patients

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