Effect of intravitreal anti-VEGF on choroidal thickness in patients with diabetic macular edema using spectral domain OCT

Kniggendorf, Vinícius; Novais, Eduardo Amorim; Kniggendorf, Sergio L.; Xavier, Camilla; Cole, Emily; Regatieri, Caio V.

doi:10.5935/0004-2749.20160047

Cited by 22 publications

(17 citation statements)

References 27 publications

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“…It has been shown that choroid plays an important role in scleral remodeling via the synthesis of several growth factors including VEGF [35], hepatocyte growth factor [36], and basic fibroblast growth factor [37]. Previous studies revealed that IVB and IVR decrease choroidal thickness and volume significantly in an adult population with diabetic macular edema and age-related macular degeneration [38][39][40]. Since diabetic macular edema and ROP are results of retinal vascular disturbances, we can assume that IVB and IVR might cause reduction in choroidal thickness and volume in infants with ROP, which in turn might affect the choroidal mechanisms of emmetropization.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Bevacizumab and Ranibizumab in the Treatment of Type 1 Retinopathy of Prematurity Affecting Zone 1

Kimyon

Mete²

2018

Ophthalmologica

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Purpose: To investigate the effects of bevacizumab and ranibizumab in the treatment of type 1 retinopathy of prematurity (ROP) affecting zone 1. Methods: Files of the patients who received intravitreal bevacizumab (IVB) or ranibizumab (IVR) treatment for ROP affecting zone 1 were evaluated retrospectively. Spherical equivalent (SE) and axial length (AXL) measurements were performed at 1 year of adjusted age. Results: Sixty-eight eyes of 37 patients were included in the study. All patients had initial disease regression but 6 patients (4 in the IVB, 2 in the IVR group) showed reactivation (p = 0.679). The number of eyes with incomplete vascularization were 15 and 12 in the IVB and IVR groups, respectively (p = 0.725). Mean AXL was 20.50 ± 0.99 mm in the IVB group and 19.30 ± 0.48 mm in the IVR group (p < 0.001). Mean SE was –1.49 ± 2.38 dpt in the IVB group and 0.98 ± 2.18 dpt in the IVR group (p < 0.001). Conclusion: Bevacizumab and ranibizumab showed similar effectiveness in the treatment of type 1 ROP affecting zone 1. The AXL was longer and SE was more myopic in eyes treated with IVB. This difference might be caused by the longer intravitreal half-life of bevacizumab than ranibizumab.

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Section: Discussionmentioning

confidence: 99%

Comparison of Bevacizumab and Ranibizumab in the Treatment of Type 1 Retinopathy of Prematurity Affecting Zone 1

Kimyon

Mete²

2018

Ophthalmologica

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“…These studies have shown that CT can be influenced by a number of factors: thinning with age (Margolis & Spaide 2009;Li, Yang & Dong 2012;Ho et al 2013;Ho et al 2013;Wei et al 2013), axial length (Margolis & Spaide 2009;Barteselli et al 2012;Tan et al 2012;Wei et al 2013), refractive power, high myopia (El Matri et al 2013;Ho et al 2013) and after panphotocoagulation laser treatment (Lee, Lim & Shin 2013, Okamoto, Matsuura & Ogata 2016, Regatieri et al 2012, Unsal et al 2014, Zhang et al 2015. Anti-VEGF or dexamethasone IVI also induces a reduction in CT immediately after injection (La ıns et al 2014;Yiu et al 2014;Rayess et al 2015;Kim et al 2016;Kniggendorf et al 2016). In our study, the variation in CT was not affected by the number of IVI received and CT at the dry time did not correlate with the number of IVI received.…”

Section: Discussionmentioning

confidence: 99%

Increased choroidal thickness: a new indicator for monitoring diabetic macular oedema recurrence

Mathis

Mendes

Dot

et al. 2020

Acta Ophthalmologica

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Purpose The aim of this study was to determine whether choroidal thickness (CT) increases at the time of exudative recurrence in diabetic patients with unilateral diabetic macular oedema (DME) treated with intravitreal injections of anti‐VEGF or dexamethasone. Methods A real‐life, prospective, two‐centre study was conducted over a 9‐month period investigating diabetic patients presenting with unilateral DME treated with anti‐VEGF or dexamethasone intravitreal injections, and CT was measured manually, using the enhanced depth imaging module of the spectral domain optical coherence tomography. Choroidal thickness (CT) was measured in the morning, in both the affected and healthy eye of each patient at two timepoints: when the macula was ‘dry’ (T0) and at the time of exudative recurrence (T1). Results A total of 51 patients with unilateral DME were included. Mean CT in the affected eye was significantly thicker at the time of exudative recurrence (210.8 ± 44.1 μm at T0 versus 238.0 ± 49.0 μm at T1, p < 0.001). There was no significant variation in CT in the fellow eye (214.4 ± 52.3 µm at T0 versus 218.9 ± 53.4 µm at T1, p = 0.53). The type of intravitreal injection, the number of injections and the CT at T0 had no influence on the change in CT. Conclusion This study found that CT increased significantly in the affected eye at the time of recurrence of DME treated with anti‐VEGF or dexamethasone injections. Choroidal thickness (CT) could constitute an interesting new indicator for monitoring patients with DME.

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“…Optical coherence tomography (OCT) has become indispensable to the clinical practice of ophthalmology for various diseases such as age-related macular degeneration, glaucoma and diabetic retinopathy (Adhi and Duker, 2013; Branchini et al, 2013; Kniggendorf et al, 2016; Manjunath et al, 2011; Thomas and Duguid, 2004; Van Melkebeke et al, 2018; Wang et al, 2016). Precise structural observation of retina and choroid by OCT leads to accurate diagnosis of disease states.…”

Section: Introductionmentioning

confidence: 99%

Detection of microvascular retinal changes in type I diabetic mice with optical coherence tomography angiography

Uehara

Lesuma

Stocking

et al. 2019

Experimental Eye Research

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Optical coherence tomography (OCT) angiography is a dye-free and non-invasive angiography which allows visualization of retinal and choroid vascular flow, enabling observation of highly permeable and three dimensional vasculature. Although OCT angiography is providing new insights in human retinal and choroidal diseases, a few studies have been reported in experimental mice. In this study, to determine the potential of OCT angiography in experimental mice, we sought to examine whether OCT angiography can detect vascular change in type I diabetic mice. To conduct age dependent analysis, 2 and 6 month old male type 1 diabetic Ins2Akita/+ and age matched C57BL/6J mice were used. OCT angiography was performed by Heidelberg Spectralis OCT Angiography Module with 30 degree lens + mouse adapter lens. We acquired the OCT angiography image from the peripheral nasal position. For analysis of OCT angiography images, OCT angiography positive area were used for vascular density. We analyzed vascular density from the retinal surface (inner limiting membrane) to 120μm depth with 4μm steps in order to correlate vascular density vs depth (N=4 per group). Vascular density of both mouse strains demonstrated three different peaks. By comparing with the OCT image, the first peak (superficial), second peak (intermediate) and third peak (deep) were located in nerve fiber layer/ganglion cell layer, inner plexiform layer/inner nuclear layer and outer plexiform layer/outer nuclear layer, respectively. We calculated vascular density of these peaks separately. In C57BL/6J mice, the vascular density in all three layers do not show significant difference between 2- and 6-month-old. On the other hand, 6-month-old Ins2Akita/+ mice showed a significant decrease of the vascular density in all three layers compared to 2-month-old Ins2Akita/+ mice. Also, the vascular density of 6-month-old Ins2Akita/+ mice in the deep layer showed a significant decrease compared to 2- and 6-month-old C57BL/6J mice. Thus, OCT angiography successfully detects retinal vascular difference between type I diabetic mice and control mice, and age-dependent vasculature change in type I diabetic mice. The diabetic mice demonstrated reduced vascular density due to reduced density of flowing deep vessels. Importantly, we observed this difference without retinal blood leakage, hemorrhage or neovascularization. Our analysis (vascular density vs retinal depth) suggests that OCT angiography is useful for in vivo detection of retinal vasculature alteration in experimental mice.

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Effect of intravitreal anti-VEGF on choroidal thickness in patients with diabetic macular edema using spectral domain OCT

Cited by 22 publications

References 27 publications

Comparison of Bevacizumab and Ranibizumab in the Treatment of Type 1 Retinopathy of Prematurity Affecting Zone 1

Comparison of Bevacizumab and Ranibizumab in the Treatment of Type 1 Retinopathy of Prematurity Affecting Zone 1

Increased choroidal thickness: a new indicator for monitoring diabetic macular oedema recurrence

Detection of microvascular retinal changes in type I diabetic mice with optical coherence tomography angiography

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