Treatment success of laser therapy for retinopathy of prematurity in referred and non-referred patients

Kara, Caner; Petriçli, İkbal Seza; Hekimoğlu, Emre; Akıl, Handan; Beyazyıldız, Özlem

doi:10.5935/0004-2749.20160029

Cited by 3 publications

(3 citation statements)

References 19 publications

(24 reference statements)

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“…In this study, despite presenting the most severe cases, whose the most affected zone was the 3, requiring laser treatment, we observed a predominance of ROP in zone 2, which corroborates with study (20) , showing that the mostly affected zone was considered of stage 3.…”

Section: Discussionsupporting

confidence: 90%

Influence of oxygen in the development of retinopathy of prematurity

Pastro

Toso

2019

Rev. Bras. Enferm.

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Objective: to describe the influence of oxygen in retinopathy of prematurity (ROP) in premature newborns (PTNB) hospitalized in neonatal units of intensive care and undergoing ophthalmological follow-up procedures after hospital discharge. Method: retrospective cohort study, from January 2014 to June 2016, whose data collection totaled 181 charts. Descriptive and inferential statistical analysis. Results: when using oxygen (O2) in 148 PTNB (81.7%), both mask (n=141; 77.9%; p-value <0.001) and the tracheal tube predominated (n=100; 55.25; p-value <0.001) for 15 days in average. The time of use and O2 concentration of the tracheal tube (p-value <0.001), the time of mask use (p-value <0.001) and the time and concentration of O2 of the continuous positive airway pressure (CPAP) (p-value <0.001) were significant to cause ROP in 50 PTNB (11.31%). Conclusion: the oxygen therapy has influenced the development and severity of ROP, indicating the need to adopt protocols for its use.

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Section: Discussionsupporting

confidence: 90%

Influence of oxygen in the development of retinopathy of prematurity

Pastro

Toso

2019

Rev. Bras. Enferm.

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“…[33][34][35] However, the success rate of laser therapy was significantly lower (p=0.01) in the referred category compared to the non-referred category, attributing to the potential delay in laser therapy and disease progression to the advanced stage at the time of treatment initiation. 36 Laser therapy also minimizes systemic side effects and recurrent/persistent avascular zones. 33 Recent evidence shows that a two-session laser procedure in AROP is associated with fewer and smaller hemorrhages and no fibrosis compared with a single session.…”

Section: Laser Photocoagulation Therapymentioning

confidence: 99%

Role of Anti-Vascular Endothelial Growth Factor (Anti-VEGF) in the Treatment of Retinopathy of Prematurity: A Narrative Review in the Context of Middle-Income Countries

Dogra¹,

Vinekar²

2023

PHMT

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The rise in preterm births and higher survival rates of premature infants have led to a global increase in retinopathy of prematurity (ROP), a vasoproliferative retinal disorder common in premature infants. ROP is one of the leading causes of childhood blindness. Clinical manifestation of ROP ranges from mild abnormal retinal neovascularization to bilateral retinal detachment and vision loss. The incidence of ROP is higher in middle income countries, including India, which has the highest number of global preterm births. Low birth weight and low gestational age are the primary risk factors for ROP; however, anemia, cardiac defects, blood transfusion, apnea, sepsis, respiratory distress syndrome, high exposure to oxygen and poor postnatal weight gain may also contribute to its development. India has stringent ROP screening guidelines revised in 2018, and screening of infants with either birth weight <2000 grams or gestational age <34 weeks is mandated. With an improved understanding of the pathogenesis of ROP in the past decades and advances in clinical research, treatment for ROP has evolved from cryotherapy to laser retinal ablation. Most recently, anti-vascular endothelial growth factor (anti-VEGF) drugs have emerged as a favorable treatment option for zone-I and II ROP. This article reviews the current approaches for ROP treatment in India with a particular focus on anti-VEGF drugs. The article also integrates the understanding of safety and risk-benefit evaluation of the current approaches in ROP management. The review concluded that there is a need to increase the ROP screening not only for preterm and low birth weight but also for optimal gestational age infants with healthy birth weight. Anti-VEGF therapies have shown improved efficacy, although studies are required to establish the long-term safety.

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“…Success rates, even in less developed nations, exceed 90% [3, 14, 15]. Anti-vascular endothelial growth factor (VEGF) therapy has arisen, with the discovery that VEGF levels rise in phase 2 ROP.…”

Section: Introductionmentioning

confidence: 99%

Anatomic outcomes of laser indirect ophthalmoscopy for retinopathy of prematurity in a tertiary referral center in the Philippines

Chan

Herrera-Arroyo

2019

BMC Res Notes

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Objective Laser/photocoagulation criteria for retinopathy of prematurity (ROP) are generally universal, with > 90% anatomic success reported in varied settings. Outcomes in the Philippines, a developing/lower-middle income nation, were examined. Results This single-center retrospective chart review covered years 2014 and 2015. Of 214 infants screened, 64 had any ROP. Thirty-four were treated, and 20 had documented outcomes. Only 15 of 25 eyes (8 infants) with laser treatment-requiring ROP were successes (60%). All infants had Type 1 ROP except one with Aggressive Posterior ROP. Seven infants with bilateral “Milder than Type 1” ROP were treated successfully. Type 1 ROP treatment failures versus successes did not differ significantly in birth weight (1009 g vs. 1112.86 g, p = .5152), birth age of gestation (27.74 vs. 28.49 weeks, p = .3290), and, delay in first screening (6.74 vs. 5 weeks, p = .4649). Poorer outcomes of laser treatment-requiring ROP were documented here compared with elsewhere in the world. Variables/risk factors examined were limited and human error was not systematically considered. Subsequent studies validating this trend should incorporate other clinical (e.g. maternal/neonatal risk factors) and environmental differences that might drive pathology and treatment response in this multifactorial disease. Adherence to protocols gains importance given the widespread delay and early loss to follow-up observed. Electronic supplementary material The online version of this article (10.1186/s13104-019-4303-3) contains supplementary material, which is available to authorized users.

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Treatment success of laser therapy for retinopathy of prematurity in referred and non-referred patients

Cited by 3 publications

References 19 publications

Influence of oxygen in the development of retinopathy of prematurity

Influence of oxygen in the development of retinopathy of prematurity

Role of Anti-Vascular Endothelial Growth Factor (Anti-VEGF) in the Treatment of Retinopathy of Prematurity: A Narrative Review in the Context of Middle-Income Countries

Anatomic outcomes of laser indirect ophthalmoscopy for retinopathy of prematurity in a tertiary referral center in the Philippines

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