Retinal nerve fiber layer, ganglion cell complex, and choroidal thicknesses in migraine

Abstract

Espessuras da camada de fibras nervosas retinianas, complexo de células ganglionares e coroide na enxaqueca ABSTRACTPurpose: To evaluate the thicknesses of the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCL), and choroid layer using spectral domain optical coherence tomography (SD-OCT) for investigating the effects of vascular changes on the eye and optic nerve in patients who have migraine with aura. Methods: Forty-five patients who had migraine with aura (migraine group) and 45 healthy individuals (control group) were enrolled in the study. Age, gender, duration after migraine diagnosis, intraocular pressure, and axial length measurements were recorded in each case. RNFL, GCL, and choroid layer thicknesses were measured using SD-OCT in all participants. Results: The mean age was 36.1 ± 6.7 (20-45) years in the migraine group and 35.7 ± 8.6 (19-45) years in the control group. There was no significant difference in the RNFL thicknesses of the temporal and nasal quadrants (p>0.05). The RNFL thicknesses of the superior and inferior quadrants were significantly lower in the migraine group compared with those in the control group (p=0.001, p<0.01, respectively). Measurements for the superior and inferior GCL were not significantly different between the groups (p>0.05). Subfoveal, temporal, and nasal choroidal thickness measurements at 500 µm, 1000 µm, and 1500 µm were significantly lower in the migraine group than in the control group (p=0.001; p<0.01, respectively). Conclusions:Compared with the controls, the RNFL and choroid layer were determined to be thinner in patients who had chronic migraine with aura. de 36,1 ± 6,7 (20-45) anos no grupo enxaqueca e 35,7 ± 8,6 (19-45) Keywords

Retinal nerve fiber layer, ganglion cell complex, and choroidal thicknesses in migraine

“…Dear Editor, We have read and reviewed the article titled "Retinal nerve fiber layer, ganglion cell complex, and choroidal thicknesses in migraine" by Çolak et al, with great interest (1) . The authors investigated 45 migraine patients with aura and peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex, and choroid thicknesses using optical coherence tomography.…”

“…We express our gratitude to the authors regarding this study. However, we would like to ask Çolak et al to clarify some important points that might affect CT measurements (1) . The choroid is one of the most vascularized regions of the human body.…”

Indirect Traumatic Optic Neuropathy in Mild Chronic Traumatic Brain Injury

“…16,45 Furthermore, numerous studies on choroidal thickness in migraine also have been inconsistent, with some showing increased choroidal thickness, and others showing reduced thickness. [46][47][48] Because of the vasoactive effects of migraine and migraine medications on the choroidal layer thickness measurements, we minimized these effects on our data by treating all of our mTBI patients with the same medications (topiramate, sumatriptan, and botulinum toxin injections); and including only those without a migraine attack on the date of, or during, the OCT scan procedure. Retinal blood flow studies might be a better method to assess vascular damage and perfusion in future studies.…”

Optical Coherence Tomography in Patients with Chronic Migraine: Literature Review and Update

“…Several authors have used OCT to study possible changes in macular thickness in patients with migraine. Their results are contradictory because, although most found no change in either foveal or macular parameters in migraine patients ( 18 , 59 , 62 ), some reported that foveal thickness (FT) values ( 19 ) or GCL ( 61 , 64 ) were thinner in MwA than in MwoA. The more diminished blood flow in MwA would explain this finding, given that in MwoA, at least between attacks, pulsatile choroidal blood flow is not compromised.…”

“…Decreased thickness of the retinal nerve fiber layer (RNFL) has been reported in several neurological disorders, such as multiple sclerosis, Alzheimer disease, and Parkinson disease ( 16 – 18 ). Ganglion cell layer (GCL) thickness could become a more appropriate morphological biomarker of axonal damage than RNFL in specific optic neuropathies ( 19 , 20 ). OCT is a reliable, reproducible, objective, non-invasive, transpupillary diagnostic technique that enables quantitative in vivo high-resolution measurement of peripapillary RNFL, GCL, and choroid layer thickness ( 21 – 23 ).…”