Investigation of the association between glaucoma and<i>Helicobacter pylori</i>infection using the<sup>14</sup>C-urea breath test

Tuzcu, Esra Ayhan; Aydogan, Fusun; Motor, Vicdan Köksaldı; İlhan, Özgür; Dağlioğlu, Mutlu Cıhan; Çoşkun, Mesut; Parlakfikirer, Nihan; Keskın, Uğurcan

doi:10.5935/0004-2749.20150059

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Two of these were excluded, as extra data were needed and these were not provided by the corresponding authors, and/or the methodology was doubtful [ 43 , 44 ]. Therefore, 15 final studies were considered for the meta-analysis and included 2664 participants (872 patients with glaucoma and 1792 controls) with three types of glaucoma (POAG, NTG, PEG) [ 19 , 22 , 23 , 24 , 34 , 41 , 42 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. One potential type (ocular hypertension), reported by Galloway et al [ 24 ] was excluded because it did not meet our own inclusion criteria.…”

Section: Resultsmentioning

confidence: 99%

Association between Active Helicobacter pylori Infection and Glaucoma: A Systematic Review and Meta-Analysis

et al. 2020

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Background: Glaucoma is the second most common cause of blindness worldwide affecting almost 70 million individuals. Helicobacter pylori (H. pylori) is a widespread pathogen with systematic pathogenicity. This meta-analysis aimed to estimate the contradictory data regarding a potential association between active H. pylori infection and glaucoma. Materials and Methods: A research in MEDLINE/PubMed and Google Scholar was conducted and original studies investigating the relationship between H. pylori infection and glaucoma were included. Analysis was performed with random effects model. The main outcome was the odds ratio (OR) with 95% confidence intervals (CI) of H. pylori infection as a risk factor for glaucoma. A parallel analysis studied the role of active infection as indicated by histology and the titer of anti-H. pylori antibodies. For the anti-H. pylori antibody titers, weighted mean differences (WMD) were estimated between patients and controls. Results: Fifteen studies were included, with 2664 participants (872 patients with glaucoma and 1792 controls), divided into primary open-angle glaucoma (POAG), normal tension glaucoma (NTG) and pseudo-exfoliation glaucoma (PEG). The association between H. pylori infection and overall glaucoma was significant (OR = 2.08, CI 95% 1.48–2.93) with moderate heterogeneity (I2 = 61.54%). After stratification by glaucoma subtype, heterogeneity was eliminated in the NTG subgroup. Studies with healthy controls, and controls with anemia yielded very low or no heterogeneity, respectively. Gastric biopsy to document active H. pylori infection yielded the highest OR (5.4, CI: 3.17–9.2, p < 0.001) and null heterogeneity. For anti-H. pylori antibody titers, there was a significant difference in WMD between patients and controls (WMD 15.98 IU/mL; 95% CI: 4.09–27.87; p = 0.008); values were greater in glaucoma patients, with high heterogeneity (I2: 93.8%). Meta-regression analysis showed that mean age had a significant impact on glaucoma (p = 0.037). Conclusions: Active H. pylori infection may be associated with glaucoma with null heterogeneity, as, beyond histology, quantified by anti-H. pylori titers and increases with age.

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Section: Resultsmentioning

confidence: 99%

Association between Active Helicobacter pylori Infection and Glaucoma: A Systematic Review and Meta-Analysis

et al. 2020

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“…As studies evaluating potential associations between H. pylori infection and POAG have reported positive [19,20,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] or no association [39][40][41][42][43][44], Controversy still exists. For this reason, this study aimed to elucidate the putative link between primary open-angle glaucoma (POAG) and H. pylori infection in all possible combinations.…”

Section: Introductionmentioning

confidence: 99%

Association between helicobacter pylori infection and primary open-angle glaucoma: a systematic review and meta-analysis

Ezzati Amini,

Moradi

2023

BMC Ophthalmol

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Purpose This systematic review and meta-analysis summarize the evidence for the association between Helicobacter pylori infection and Primary Open-Angle Glaucoma. Methods Eligible studies reporting an association between H. pylori infection and Glaucoma were identified through an extensive search of the Excerpta Medica (EMBASE), Web of Science, Scopus, and PubMed databases and an assessment of the reference list of the top articles until October 2022. Analysis was performed with random effects model using Stata 16. Result Twenty-four studies were included in the systematic review. This study involved 1602 glaucoma patients and 2800 control individuals. The combined RRs of cohort studies and overall combined ORs of case-control studies showed a significant correlation between H. pylori infection and Glaucoma. Subgroup analysis showed that glaucoma patients had a higher risk of having H. pylori infection if they were residents of Europe countries (Cohort: RR: 1.69; 95% CI: 1.3–2.19) and (Case-Control: RR: 3.71; 95% CI: 2.07–6.64), if they had POAG type (Cohort: RR: 1.76; 95% CI: 1.37–2.27) and (Case-Control: RR: 3.71; 95% CI: 2.934.70), if their diagnostic method of HP was histology (Cohort: RR: 1.95; 95% CI: 1.26–3.01) and (Case-Control: RR: 4.06; 95% CI: 2.28–7.22), and if they were over 60 years old (Cohort: RR: 1.63; 95% CI: 1.33-2.00) and (Case-Control: RR: 2.95; 95% CI: 2.27–3.83). Discussion The results of this meta-analysis suggest a statistically significant association between Helicobacter pylori infection and Primary Open-Angle Glaucoma.

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“…Dennoch entsprachen diese Daten anderen afrikanischen Studien, welche die Prävalenzrate der H.-pylori-Infektion in der Allgemeinbevölkerung mit 60-94 % angeben[26]. In der Tat ist die Prävalenzrate einer H.-pylori-Infektion umgekehrt proportional zum sozioökonomischen Status[27].Im gleichen Jahr fanden Tuzcu et al bei einer Studie an POAG-Patienten in der Türkei ebenfalls keinen Zusammenhang zwischen einem Glaukom und einer H.-pylori-Infektion[28]. So war der Harnstoff-Atemtest bei 51 % der POAG-Patienten in dieser Studie positiv, aber auch bei 43 % der Kontrollpersonen.…”

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Bedeutung der Helicobacter-pylori-Diagnostik beim Glaukom

Joachim

2018

Klin Monatsbl Augenheilkd

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Glaucoma is one of the most common causes for blindness worldwide. Even if some risk factors for this disease are known, like increased intraocular pressure or increased age, its pathomechanism is still not fully understood. Multiple studies recently analyzed the role of a Helicobacter pylori infection in the glaucoma pathogenesis. Several studies showed a correlation, while others did not come to this conclusion. In summary, it is very likely that a Helicobacter pylori infection coincides with an increased risk for a primary open-angle or normal-tension glaucoma. Still, larger studies, with strict inclusion and exclusion criteria, as well as age-matched control groups, are needed to find out if a Helicobacter pylori infection really leads to a higher risk for glaucoma.

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Investigation of the association between glaucoma andHelicobacter pyloriinfection using the¹⁴C-urea breath test

Cited by 6 publications

References 26 publications

Association between Active Helicobacter pylori Infection and Glaucoma: A Systematic Review and Meta-Analysis

Association between Active Helicobacter pylori Infection and Glaucoma: A Systematic Review and Meta-Analysis

Association between helicobacter pylori infection and primary open-angle glaucoma: a systematic review and meta-analysis

Bedeutung der Helicobacter-pylori-Diagnostik beim Glaukom

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Investigation of the association between glaucoma andHelicobacter pyloriinfection using the14C-urea breath test

Cited by 6 publications

References 26 publications

Association between Active Helicobacter pylori Infection and Glaucoma: A Systematic Review and Meta-Analysis

Association between Active Helicobacter pylori Infection and Glaucoma: A Systematic Review and Meta-Analysis

Association between helicobacter pylori infection and primary open-angle glaucoma: a systematic review and meta-analysis

Bedeutung der Helicobacter-pylori-Diagnostik beim Glaukom

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Investigation of the association between glaucoma andHelicobacter pyloriinfection using the¹⁴C-urea breath test