Acute retinal necrosis following intravitreal dexamethasone (Ozurdex®) implant

Küçükevcilioğlu, Murat; Eren, Mustafa; Yolcu, Ümit; Sobacı, Güngör

doi:10.5935/0004-2749.20150030

Cited by 24 publications

(13 citation statements)

References 8 publications

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“…Secondly, viral retinitis may represent an underreported and/or unrecognised risk of Ozurdex administration. To our knowledge, there are only four reports, including our own, of viral retinitis following Ozurdex treatment (Ozturk et al 2014;Kucukevcilioglu et al 2015;Vannozzi et al 2016). Conversely, intravitreal triamcinolone has been associated with a 0.41% incidence of viral retinitis in large systematic case series (Shah et al 2010).…”

Section: Referencesmentioning

confidence: 89%

Acute retinal necrosis and ocular neovascularization caused by cytomegalovirus following intravitreal dexamethasone implant (Ozurdex^®) in an immunocompetent patient

Thrane

Hove

Kjersem

et al. 2016

Acta Ophthalmologica

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Section: Referencesmentioning

confidence: 89%

Acute retinal necrosis and ocular neovascularization caused by cytomegalovirus following intravitreal dexamethasone implant (Ozurdex^®) in an immunocompetent patient

Thrane

Hove

Kjersem

et al. 2016

Acta Ophthalmologica

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“…Two cases of CMV retinitis and one of ARN are reported after fluocinolone acetonide 0.59 mg implant (Retisert) . Dexamethasone 0.7 mg implant (Ozurdex) has been implicated in one case of ARN …”

Section: Acute Retinal Necrosismentioning

confidence: 99%

“…7 Regional corticosteroids are a known but rare risk factor. 14,[29][30][31][32][33][34][35][36] ARN can occur after intravitreal or periocular injections, 14,30,[32][33][34][35][36] and rarely after systemic or epidural administration. 14,29,31,37 Overall, local steroid injections precipitate CMV retinitis three times more frequently than HSV or VZV retinitis.…”

Section: Acute Retinal Necrosismentioning

confidence: 99%

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Viral retinitis: diagnosis and management in the era of biologic immunosuppression: A review

Lightman

Tomkins-Netzer

2019

Clinical Exper Ophthalmology

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Necrotising retinitis is a rare ocular infection that historically led to high rates of visual morbidity. While acute retinal necrosis occurs in immunocompetent patients, the majority of cases are associated with immunocompromise such as in cytomegalovirus retinitis and progressive outer retinal necrosis. This review summarises the clinical and diagnostic features, management, and outcomes of herpetic retinitis. Iatrogenic immunosuppression is increasingly being utilised for a wide range of indications, and biologic agents especially so due to their targeted nature. While the intended actions are well‐studied, the flow‐on effects and complex interaction with host immunity are not well understood. Furthermore, biologics are frequently used concomitantly with other immunosuppressive agents, potentiating the immunodepression. This article reviews the literature on biologic immunosuppression and viral retinitis, and presents an approach to the vulnerable or affected patient. Early identification, prompt and aggressive treatment, and a multidisciplinary approach to managing immunodeficiency are the cornerstones of management.

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“… 50 The dexamethasone delivery system may migrate into the anterior chamber in pseudophakic or aphakic eyes, 51 which requires surgical removal ( Figure 2 ). 52 Less frequently reported complications include endophthalmitis, 53 acute retinal necrosis due to varicella zoster virus, 54 and retinal and vitreous hemorrhage due to retinal impact during injection. 55 …”

Section: Dexamethasonementioning

confidence: 99%

Update on corticosteroids for diabetic macular edema

Schwartz¹,

Stewart²,

Flynn³

2016

OPTH

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Diabetic macular edema (DME) remains an important cause of visual loss. Although anti-vascular endothelial growth factor (VEGF) agents are generally used as first-line treatments for patients with center-involving DME, there is an important role for corticosteroids as well. Corticosteroids may be especially useful in pseudophakic patients poorly responsive to anti-VEGF therapies, in patients wishing to reduce the number of required injections, and in pregnant patients. Intravitreal triamcinolone acetonide has been used for many years but is not approved for this indication. An extended-release bioerodable dexamethasone delivery system and an extended-release nonbioerodable fluocinolone acetonide insert have both achieved regulatory approval for the treatment of DME. All intravitreal corticosteroids are associated with risks of cataract progression, elevation of intraocular pressure, and endophthalmitis. There is no current consensus regarding the use of corticosteroids, but they are valuable for selected patients with center-involving DME.

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Acute retinal necrosis following intravitreal dexamethasone (Ozurdex®) implant

Cited by 24 publications

References 8 publications

Acute retinal necrosis and ocular neovascularization caused by cytomegalovirus following intravitreal dexamethasone implant (Ozurdex^®) in an immunocompetent patient

Acute retinal necrosis and ocular neovascularization caused by cytomegalovirus following intravitreal dexamethasone implant (Ozurdex^®) in an immunocompetent patient

Viral retinitis: diagnosis and management in the era of biologic immunosuppression: A review

Update on corticosteroids for diabetic macular edema

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Acute retinal necrosis following intravitreal dexamethasone (Ozurdex®) implant

Cited by 24 publications

References 8 publications

Acute retinal necrosis and ocular neovascularization caused by cytomegalovirus following intravitreal dexamethasone implant (Ozurdex®) in an immunocompetent patient

Acute retinal necrosis and ocular neovascularization caused by cytomegalovirus following intravitreal dexamethasone implant (Ozurdex®) in an immunocompetent patient

Viral retinitis: diagnosis and management in the era of biologic immunosuppression: A review

Update on corticosteroids for diabetic macular edema

Contact Info

Product

Resources

About

Acute retinal necrosis and ocular neovascularization caused by cytomegalovirus following intravitreal dexamethasone implant (Ozurdex^®) in an immunocompetent patient

Acute retinal necrosis and ocular neovascularization caused by cytomegalovirus following intravitreal dexamethasone implant (Ozurdex^®) in an immunocompetent patient