Teratogen exposure and congenital ocular abnormalities in Brazilian patients with Möbius sequence

Ventura, Camila V.; Ventura, Liana Maria Vieira de Oliveira; Miller, Marilyn T.; Cronemberger, Monica Fontenele; Dias, Carlos Sousa; Dias, Maria Joaquina Marques; Gonzalez, Claudete H.; Polati, Mariza; Nakanami, Célia Regina; Brandt, Carlos Teixeira; Kuczynski, Evelyn; Goldchmit, Mauro

doi:10.5935/0004-2749.20140076

Cited by 3 publications

(2 citation statements)

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“…questionnaire 15 regarding their pregnancy history including pregnancy duration, type of delivery, and symptoms during pregnancy. A list of possible systemic and ocular symptoms and signs using colloquial language was presented and read out loud to the mothers so that they could refer if they were present during pregnancy.…”

Section: Key Pointsmentioning

confidence: 99%

Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection

et al. 2016

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IMPORTANCE The Zika virus (ZIKV) might cause microcephaly and ophthalmoscopic findings in infants of mothers infected during pregnancy. OBJECTIVE To assess and identify possible risk factors for ophthalmoscopic findings in infants born with microcephaly and a presumed clinical diagnosis of ZIKV intrauterine infection. DESIGN, SETTING, AND PARTICIPANTS We conducted a cross-sectional study at the Altino Ventura Foundation in Recife, Brazil, that included 40 infants with microcephaly born in Pernambuco state, Brazil, between May and December 2015. Toxoplasmosis, rubella, cytomegalovirus, syphilis, and human immunodeficiency virus were ruled out in all of them. Testing of cerebrospinal fluid for ZIKV using IgM antibody-capture enzyme-linked immunosorbent assay was performed in 24 of 40 infants (60.0%). The infants and mothers underwent ocular examinations. The infants were divided into 2 groups, those with and without ophthalmoscopic alterations, for comparison. MAIN OUTCOMES AND MEASURES Identification of risk factors for ophthalmoscopic findings in infants born with microcephaly and ZIKV intrauterine infection. RESULTS Among the 40 infants, the mean (SD) age was 2.2 (1.2) months (range, 0.1-7.3 months). Of the 24 infants tested, 100% had positive results for ZIKV infection: 14 of 22 infants (63.6%) from the group with ophthalmoscopic findings and 10 of 18 infants (55.6%) from the group without ophthalmoscopic findings. The major symptoms reported in both groups were rash by 26 mothers (65.0%), fever by 9 mothers (22.5%), headache by 9 mothers (22.5%), and arthralgia by 8 mothers (20.0%). No mothers reported conjunctivitis or other ocular symptoms during pregnancy or presented signs of uveitis at the time of examination. Thirty-seven eyes (46.3%) of 22 infants (55.0%) had ophthalmoscopic alterations. Ten mothers (71.4%) of infants with ocular findings reported symptoms during the first trimester (frequency, 0.48; 95% CI, 0.02-0.67; P = .04). A difference was also observed between the groups of infants with and without ocular findings regarding the cephalic perimeter: mean (SD) of 28.8 (1.7) and 30.3 (1.5), respectively (frequency, −1.50; 95% CI, −2.56 to −0.51; P = .004). CONCLUSIONS AND RELEVANCE Ocular involvement in infants with presumed ZIKV congenital infection were more often seen in infants with smaller cephalic diameter at birth and in infants whose mothers reported symptoms during the first trimester.

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Section: Key Pointsmentioning

confidence: 99%

Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection

et al. 2016

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“…All 24 infants that underwent IgM MAC-ELISA had CSF findings positive for ZIKV: 14 (63.6%) of 22 infants from the group with ophthalmoscopic findings and 10 (55.6%) of 18 infants from the group without ophthalmoscopic findings. An educational psychologist interviewed all mothers to record pregnancy duration, mode of delivery, and symptoms during pregnancy according to a standardized questionnaire (Ventura et al, 2014).…”

Section: Risk Factors For Ophthalmoscopic Findings In Infants With Czsmentioning

confidence: 99%

Zika and the Eye: Pieces of a Puzzle

Dias

Ventura

Freitas

et al. 2018

Progress in Retinal and Eye Research

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A systematic review of in utero cannabis exposure and risk for structural birth defects

et al. 2023

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IntroductionCannabis use among pregnant women has increased over time. Therefore, there is a great public health need to understand the consequences of in utero cannabis exposure. While several meta-analyses and reviews have summarized the evidence of in utero cannabis exposure on adverse obstetric outcomes (e.g., low birth weight and preterm birth) and long-term offspring development, there has not been a focus on in utero cannabis exposure and risk for structural birth defects.MethodsWe conducted a systematic review using PRISMA guidelines to evaluate the association between in utero cannabis exposure and structural birth defects.ResultsWe identified 20 articles to include in our review and focused on interpreting findings from the 12 that adjusted for potential confounders. We report findings by seven organ systems. Within the 12 articles, four reported on cardiac malformations, three reported on central nervous system malformations, one reported on eye malformations, three reported on gastrointestinal malformations, one reported on genitourinary malformations, one reported on musculoskeletal malformations, and two reported on orofacial malformations.DiscussionFindings on associations between in utero cannabis exposure and birth defects reported in more than two articles were mixed (i.e., findings for cardiac, gastrointestinal, central nervous system malformations). Findings for associations between in utero cannabis exposure and birth defects reported in two articles (i.e., orofacial malformations) or in a single article (eye, genitourinary, and musculoskeletal) suggested that cannabis exposure was not associated with these types of malformations, but strong conclusions cannot be drawn from such sparce research. We review the limitations and gaps in the existing literature and call for more research to rigorously evaluate associations between in utero cannabis exposure and structural birth defects.Systematic Review Registrationidentifier CRD42022308130.

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Teratogen exposure and congenital ocular abnormalities in Brazilian patients with Möbius sequence

Cited by 3 publications

References 25 publications

Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection

Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection

Zika and the Eye: Pieces of a Puzzle

A systematic review of in utero cannabis exposure and risk for structural birth defects

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