Condição de saúde ocular em idosos residentes em asilos de Curitiba - Brasil

Ávila, Sandra Zandavalli; Ramos, Ayrton R. B.; Moreira, Hamílton; Moreira, Carlos Augusto; Júnior, Carlos Augusto Moreira

doi:10.5935/0004-2749.19930047

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…Embora a catarata seja uma patologia com diagnóstico muito fácil e simples, ainda é a principal causa de deficiência visual relacionada ao envelhecimento, sobretudo nos países em desenvolvimento e nos subdesenvolvidos. As dificuldades socioeconômicas, a falta de educação e informação e as dificuldades na assistência médica especializada são os principais fatores a contribuir para esta calamitosa situação (12,(15)(16) . A prevalência de catarata, mesmo nos países desenvolvidos, aumenta significativamente com o aumento da idade.…”

Section: Flávio Antônio Romani* Introduçãounclassified

Prevalência de transtornos oculares na população de idosos residentes na cidade de Veranópolis, RS, Brasil

Romani¹

2005

Arq. Bras. Oftalmol.

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Section: Flávio Antônio Romani* Introduçãounclassified

Prevalência de transtornos oculares na população de idosos residentes na cidade de Veranópolis, RS, Brasil

Romani¹

2005

Arq. Bras. Oftalmol.

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“… 7 In developing countries, such as Brazil, it is in the third place, but, due to alterations in the epidemiological profile and aging of the population, this is expected to change. 8 …”

Section: Introductionmentioning

confidence: 99%

Intravitreal use of bone marrow mononuclear fraction containing CD34<sup>+</sup> stem cells in patients with atrophic age-related macular degeneration

Cotrim¹,

Toscano²,

Messias³

et al. 2017

OPTH

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PurposeTo evaluate the therapeutic potential and safety of intravitreal injections of bone marrow mononuclear fraction (BMMF) containing CD34+ cells in patients with atrophic age-related macular degeneration (AMD).MethodsTen patients with atrophic AMD and best-corrected visual acuity (BCVA) in the worse-seeing eye of ≤20/100 were enrolled in this study. The bone marrow from all patients was aspirated and processed for mononuclear cell separation. A 0.1 mL suspension of BMMF CD34+ cells was injected into the vitreous cavity of the worse-seeing eye. Patients were evaluated at Baseline and 1,3,6,9 and 12 months after injection. Ophthalmic evaluation included BCVA measurement, microperimetry, infrared imaging, fundus autofluorescence and SD-optical coherence tomography at all study visits. Fluorescein angiography was performed at Baseline and at 6 and 12 months after intravitreal therapy.ResultsAll patients completed the 6-month follow-up, and six completed the 12-month follow-up. Prior to the injection, mean BCVA was 1.18 logMAR (20/320−1), ranging from 20/125 to 20/640−2, and improved significantly at every follow-up visit, including the 12-month one, when BCVA was 1.0 logMAR (20/200) (P<0.05). Mean sensitivity threshold also improved significantly at 6, 9 and 12 months after treatment (P<0.05). Considering the area of atrophy identified by fundus autofluorescence, significant mean BCVA and mean sensitivity threshold improvement were observed in patients with the smallest areas of atrophy. Fluorescein angiography did not identify choroidal new vessels or tumor growth.ConclusionThe use of intravitreal BMMF injections in patients with AMD is safe and is associated with significant improvement in BCVA and macular sensitivity threshold. Patients with small areas of atrophy have a better response. The paracrine effect of CD34+ cells may explain the functional improvement observed; however, larger series of patients are necessary to confirm these preliminary findings.

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Condição de saúde ocular em idosos residentes em asilos de Curitiba - Brasil

Cited by 2 publications

References 2 publications

Prevalência de transtornos oculares na população de idosos residentes na cidade de Veranópolis, RS, Brasil

Prevalência de transtornos oculares na população de idosos residentes na cidade de Veranópolis, RS, Brasil

Intravitreal use of bone marrow mononuclear fraction containing CD34<sup>+</sup> stem cells in patients with atrophic age-related macular degeneration

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