Liver and Kidney Dysfunction in Wistar Rats Exposed to Municipal Landfill Leachate

Quality Assessment of Waterside River, Ogbor Hill Aba 4: Effect of Three-Point Samples on Hepatic Histo-Morphology and Some Seric Bio-Functional Indicators of Wistar Rats

“…Generally, the increase in these enzymes activity (ALT, AST and ALP) may be due to necrosis of the liver and other high metabolic organs that resulted to increased permeability of the organs following toxic assault and resultant damage of the organs [35,36] . Heavy metals as noted in the WRO samples in this stud could induce damage on the liver (and other high metabolic organs) resulting to increased cell membrane permeability [16] hence increased release of the enzymes. These alterations could be defense response of the rats against heavy metals [6] .…”

“…This invariably indicated overriding adverse influence of downstream or midstream samples exposure on the rats' liver since ALT is a specific marker for liver damage [31] . In previous studies, increased serum ALT activity indicated liver injury [20,16] . Thus, the lower serum ALT activity in the upstream-exposed rats could be suggestive that upstream sample of WRO did not elicit hepatotoxic effect in the rats.…”

“…This suggested sample-dependent compromised liver and/or other high metabolic organs in the rats since AST enzyme occurs in other high metabolic organs aside the liver. Serum AST and ALT are the most used biochemical markers of hepatocellular necrosis and are considered sensitive indicators of hepatic injury [16] . Heavy metals-induced hepatoxicity have been reported [32] and did result to rise in transaminases in various animals [33,34] .…”

“…Enzyme activity is particularly important in assessing pathological conditions [15] . And, serum alanine aminotransferase and aspartate aminotransferase activities are particularly most used biochemical indicators of hepatocellular injury [16] . The results of this study could provide further insight into the quality status of, and possible hepatic health implications of consuming, WRO.…”

Assessing the Quality of Household and Drinking Water in Tongi Industrial Zone of Bangladesh and Its Toxicological Impact on Healthy Sprague Dawley Rats

“…The hearts, kidneys, lungs, livers, and spleens of all rats were surgically removed by using sharp blade and scissors, rinsed with physiological saline, blotted dried and then weight of individual organ was measured. After obtaining the fresh organs weight of heart, kidney, lungs, liver, and spleen of each rat, the organs was preserved in 10% formaldehyde (pH 7.2 to 7.4) and sections of tissues were cut for histological procedures [18,19].…”