Clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile

Fujimoto, Denys Eiti; Koifman, Sérgio

doi:10.5581/1516-8484.20140027

Cited by 31 publications

(24 citation statements)

References 12 publications

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“…A study from Brazil and Pakistan had similar results to this study in terms of eosinophilia, the study showing that around 20% of patients had a higher eosinophil count on day 10 of the fever [5, 9]. In cases of dengue infection, eosinophil levels were low in the acute phase due to the response to the inflammatory process, the levels then returning to baseline and increasing in the convalescence phase [15].…”

Section: Discussionsupporting

confidence: 73%

“…The clinical presentations in dengue infection are fever, headache, loss of appetite, nausea, bleeding diathesis, myalgia, abdominal pain, sore throat and diarrhea [5, 8, 9]. These symptoms are not specific and can be found in other infections.…”

Section: Discussionmentioning

confidence: 99%

“…The data from Brazil demonstrated mean white blood cell count (WBC) of dengue infected patients was 4.6 × 10 9 /L with the lowest count of 0.7 × 10 9 /L and the mean platelet count was 26.4 × 10 9 /L with the lowest count registered was less than 1 × 10 9 /L [5]. …”

Section: Introductionmentioning

confidence: 99%

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Useful clinical features and hematological parameters for the diagnosis of dengue infection in patients with acute febrile illness: a retrospective study

et al. 2018

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BackgroundDengue infection patients are presented with acute febrile illness. Clinical presentations may mimic other infections. The serology for definite diagnosis is costly and inaccessible in many hospitals. We sought to identify the clinical features and hematologic parameters from a complete blood count (CBC) which distinguish dengue infection from other causes.MethodsThis was a retrospective single center study from Chiang Mai University Hospital. All patients who presented with acute fever between September 2013 and July 2015 were included. The diagnosis of dengue infection must be confirmed by serology. The control groups were patients who presented with acute febrile illness without localizing signs. Clinical data and CBC results were reviewed and compared. The Chi-square test was used to compare categorical variables. The CBC parameters were analyzed using the linear mixed model.ResultsOne hundred and fifty-four dengue and 146 control patients were included. Headache, nausea, loss of appetite and bleeding diathesis were significantly symptoms in dengue patients (p < 0.05). There was some diversity in the the CBC in the dengue patients compared to the control group. Moreover, this study also identified the day of fever which these parameters were statistically significant. The dengue group had higher hemoglobin and hematocrit from day 3 to day 10 (p < 0.001), lower white blood cell count from day 1 to day 10 (p < 0.001), lower platelet count from day 3 to day 10 (p < 0.001), higher monocyte on day 1–4 (p < 0.001), higher atypical lymphocyte percentage on day 5–9 (p < 0.001) and higher eosinophil percentage on day 9–10 (p = 0.001). Furthermore, the neutrophil to lymphocyte percentage ratio of dengue group was > 1 on the first 5 days then reversed on day 6 to Day 9 but in non-dengue group, the ratio was always > 1.ConclusionWe identified important clinical features and CBC parameters to differentiate dengue patients from other patients who had acute febrile illness from other causes. This identification could be done in local hospitals to give an accurate diagnosis, enabling further investigation to be tailored and treatment commenced earlier.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Useful clinical features and hematological parameters for the diagnosis of dengue infection in patients with acute febrile illness: a retrospective study

et al. 2018

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“…12.32% and 16.1% [28] respectively. Bleeding manifestations in the form of melaena, epistaxis, gum bleed, haematuria were present in total 44.4% cases as Ashwini K et al [26] reported 26.6%, but KM Mohamed et al and Tejeshree A et al reported 9.58% and 3.84% [29] respectively.…”

Section: Discussionmentioning

confidence: 99%

Study of Clinical, Laboratory Profile and Outcome of Dengue Fever Admitted in Paediatric Ward of a Tertiary Care Hospital of Western Uttar Pradesh, India

Kashif¹,

Abqari²,

Zaka-ur-Rab³

et al. 2017

jemds

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BACKGROUNDDengue Fever epidemic resurfaced this year after 2005 with more number of cases and with varying presentations and complications. The presentation can vary from a mild febrile illness to severe refractory shock or severe bleeding. Dengue is an important cause of mortality and morbidity in India. Many recent studies have shown varied clinical manifestations from different geographical locations. The present prospective observational study was conducted to find out the clinical features, complications, response to treatment and outcome of patients suffering from dengue in a tertiary care centre of Western Uttar Pradesh, India. Objective-To study the clinical, pathological, laboratory profile and outcome of the confirmed cases of Dengue fever in Paediatric age group admitted in the hospital. MATERIALS AND METHODSThe Prospective observational study was performed at Department of Paediatrics, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh which is a tertiary care hospital of Western Uttar Pradesh. The study period was from June 2013 to November 2013. Patients up to 18 years of age who were admitted in Paediatric ward and were positive for serological test (NS1 Ag, IgM /IgG) for dengue fever were included. The patients were subjected to detailed history and examination and relevant investigations were sent. RESULTSTotal 126 patients were included. Out of these, 66 were male (52.38%) and 20 were female (47.61%). Majority of them presented in critical phase on day 4-6 of illness (57.14%). Most of the cases were admitted in post monsoon period in the month of October and November. The most common presentation was fever 126 (100%) followed by petechial rash 75 (59.52%). Pruritus was present in 60 (47.61%) patients. NS1 antigen was positive in majority of patients (78, 61.9%). Thrombocytopenia was the commonest haematological abnormality. Deranged hepatic, renal and cerebral functions were noted. Total leucocyte counts were less than 4000 in most of the patients (54, 42.8%). Bleeding manifestations in the form of gum bleeding, haematuria, epistaxis, melaena were present mainly in patients having severe thrombocytopenia (<50,000/cu mm). On ECG 39(23.8%) patients were having myocarditis whereas 24 (19%) patients had pleural effusion on chest x-ray. The average duration of stay in the hospital was 6-7 days and majority of the patients were discharged on day 9-10 of illness. Comorbid conditions in the form of malaria 9 (7.1%) and enteric fever 7 (5.5%) were also noted. Blood cultures were positive in only 8 (6.3%). 8 patients expired and mortality rate was 6.3%. Shock, bleeding, encephalitis, ARDS, late presentation and diagnosis were associated with poor outcome and mortality. CONCLUSIONDengue is an important cause of mortality and morbidity in western Uttar Pradesh and adjoining areas. Community awareness, early diagnosis and management and vector control measures need to be strengthened, during peri-monsoon period, in order to curb the increasing number of dengue cases. High index of...

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“…There is no quick dengue infection confirmation test, however, a complete blood count (CBC) might show characteristics such as thrombocytopenia and leukopenia [2].…”

Section: Introductionmentioning

confidence: 99%

Platelet and Leukocyte Increasing Effects of Syzygium cumini (L.) Skeels (Myrtaceae) Leaves in a Murine Model

Tmb¹,

Mjt²

2018

Pharm Anal Acta

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Context: Syzygium cumini (L.) Skeels (Myrtaceae) is popularly known to have various pharmacological and traditional uses. Prior to this study, there were no claims reporting its potential use for dengue by increasing platelet and leukocyte levels. Objectives:The effects of the methanolic extract of S. cumini leaves on the platelet and leukocyte levels were evaluated in Sprague-Dawley rats at doses 400 mg/kg and 800 mg/kg body weight. Methodology:The bioassay utilized 24 rats that were divided into four groups (n=6) where hydroxyurea was used to induce depletion of platelet and and leukocyte levels in all groups. After induction, oral treatment of methanolic extract was given daily to the treatment groups for six days. The platelet and leukocyte counts were measured before induction to get the baseline, after induction, and at the 1st, 3rd, and 6th day of treatment. High Performance Liquid Chromatography (HPLC) analysis was also conducted to identify the phenolic compounds present in the extract. Results:Results revealed that the methanolic extract of S. cumini caused an increase of platelet counts at both 400 and 800 mg/kg and an increase in leukocyte counts at 800 mg/kg. HPLC data identified catechin and rutin at concentrations 759.16 ppm and 142.24 ppm, respectively. Conclusion:S. cumini is a potential candidate for further research leading to the development of an herbal therapeutic agent for dengue.

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Clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile

Cited by 31 publications

References 12 publications

Useful clinical features and hematological parameters for the diagnosis of dengue infection in patients with acute febrile illness: a retrospective study

Useful clinical features and hematological parameters for the diagnosis of dengue infection in patients with acute febrile illness: a retrospective study

Study of Clinical, Laboratory Profile and Outcome of Dengue Fever Admitted in Paediatric Ward of a Tertiary Care Hospital of Western Uttar Pradesh, India

Platelet and Leukocyte Increasing Effects of Syzygium cumini (L.) Skeels (Myrtaceae) Leaves in a Murine Model

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