Comment on: oxidative stress and antioxidant status in beta-thalassemia heterozygotes

Shekhar, Hossain Uddin

doi:10.5581/1516-8484.20130125

Cited by 2 publications

(3 citation statements)

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“…Reis FMP, Barbosa FT, Ramos FWS A auto-oxidação de cadeias de globina e a sobrecarga de ferro são os mecanismos sugeridos para o aumento do estresse oxidativo, tanto na beta-talassemia maior quanto na menor. (3) Hemoglobina oxidada associada às proteínas de membrana, compromete a estabilidade do eritrócito, devido ao estresse oxidativo, desempenhando importante papel na hemólise dessas células. Os mecanismos que facilitam a oxidação via formação de radicais livres são multifatoriais e resultam de cadeias globínicas livres, alto conteúdo intracelular de ferro e baixa concentração de hemoglobina (Hb) nos eritrócitos.…”

Section: Talassemiasunclassified

“…São esperados resultados semelhantes com BTM, mas em menor grau. (3) Com o objetivo de proteger o organismo de agentes pró-oxidantes, que são gerados durante o metabolismo celular e como resultado de processos patológicos, as células têm sistemas de defesas enzimático e não enzimático. O status oxidativo do eritrócito está relacionado com o equilíbrio entre a formação de agentes oxirredutores e sistema de defesa antioxidante.…”

Section: Introductionunclassified

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Beta-Thalassemia Minor and the risk of Atherosclerosis: the role of the erythrocytic oxidative stress and paraoxonase 1 levels as aggravating factors

Reis¹,

Barbosa²,

Ramos³

2017

Revista Brasileira De Análises Clínicas

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Artigo de Revisão/Review Resumo A hemoglobina pode representar uma fonte adicional de espécies reativas do oxigênio; assim, perturbações na função e estrutura dos eritrócitos podem levar ao estresse oxidativo. A auto-oxidação de cadeias de globina e sobrecarga de ferro são os mecanismos sugeridos para o aumento do estresse oxidativo, tanto na beta-talassemia maior quanto na menor. Vários estudos têm avaliado o status oxidante e antioxidante de pacientes beta-talassêmicos, mas a maioria voltada para os estados graves e intermediários da doença. Entretanto, alguns estudos demonstraram aumento do estresse oxidativo e da capacidade antioxidante na beta-talassemia menor. Nos últimos anos, novas evidências sugerem que a oxidação da lipoproteína de baixa densidade é o passo fundamental para aterogênese. A paraoxonase-1, expressa no fígado, tem sido demonstrada por estar associada às partículas de lipoproteínas de alta densidade e por possuir capacidade antioxidante, protegendo ambas as lipoproteínas de baixa e alta densidade da lipoperoxidação. Alguns estudos com beta-talassemia menor demonstraram que, além do aumento do estresse oxidativo, os níveis de paraoxonase-1 estavam diminuídos. Como a paraoxonase-1 inibe a oxidação da lipoproteína de baixa densidade, pode ser sugerido que indivíduos com beta-talassemia menor sejam mais propensos à aterosclerose do que indivíduos saudáveis. Palavras-chave Talassemia beta; Estresse oxidativo; Peroxidação de lipídeos; Aterosclerose

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Section: Talassemiasunclassified

Section: Introductionunclassified

Beta-Thalassemia Minor and the risk of Atherosclerosis: the role of the erythrocytic oxidative stress and paraoxonase 1 levels as aggravating factors

Reis¹,

Barbosa²,

Ramos³

2017

Revista Brasileira De Análises Clínicas

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“…Beta-thalassemias (both homo- and heterozygote), one common form of hemoglobinopathy, are a group of hereditary blood disorders caused by moderately low levels of hemoglobin synthesis or the absence of the beta chains of hemoglobin. [ 1 2 ] Beta-thalassemias are more common in Mediterranean countries, the Middle East, the Indian subcontinent, and many parts of Southeast Asia. [ 3 ] Since there is no effective treatment of β-thalassemia except frequent blood transfusions and bone marrow transplants, the purpose of this study was to provide some valuable information about the patients to treat them properly, though this will not reduce the number of patients except declining those with oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Respiratory burst enzymes, pro-oxidants and antioxidants status in Bangladeshi population with β-thalassemia major

et al. 2015

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Background:Oxidative stress is intimately associated with many diseases, including β-thalassemia.Aim:The study was to estimate the status of respiratory burst enzymes, pro-oxidants, and antioxidants in β-thalassemia major patients in Bangladesh and to compare with apparently healthy individuals.Materials and Methods:A total of 49 subjects were recruited which included 25 patients (age range 5 to 40 years) with β-thalassemia major and 24 controls (age and sex matched). Superoxide dismutase (SOD) and catalase (CAT) represented respiratory burst enzymes; malondialdehyde (MDA), lipid hydroperoxide (LHP), and xanthine oxidase (XO) were measured as pro-oxidants; and glutathione S transferase (GST), vitamin C (Vit.C), and glutathione (GSH) were the measured antioxidants.Results:The activity of SOD was significantly (P < 0.001) increased by about 79% and the activity of CAT was significantly (P < 0.001) decreased by more than 34% in the blood of β-thalassemia major patients compared to the control group. The content of pro-oxidants such as MDA, LHP, and XO was significantly (P < 0.001) higher in patients by about 228%, 241.3% and 148.1% respectively compared to control group. The level of GSH and Vit.C were significantly (P = 0.000) decreased in patients by about 59% and 81% versus the healthy group, respectively; and GST activity was significantly (P < 0.001) declined by 44.25% in patients group.Conclusion:β-thalassemia major patients demonstrate raised oxidative stress compared to healthy subjects.

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Comment on: oxidative stress and antioxidant status in beta-thalassemia heterozygotes

Cited by 2 publications

References 10 publications

Beta-Thalassemia Minor and the risk of Atherosclerosis: the role of the erythrocytic oxidative stress and paraoxonase 1 levels as aggravating factors

Beta-Thalassemia Minor and the risk of Atherosclerosis: the role of the erythrocytic oxidative stress and paraoxonase 1 levels as aggravating factors

Respiratory burst enzymes, pro-oxidants and antioxidants status in Bangladeshi population with β-thalassemia major

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