Glomerular filtration rate is altered in children with sickle cell disease: a comparison between Hb SS and Hb SC

Abstract

BackgroundRenal failure is common among older patients with sickle cell disease; this is preceded by subclinical glomerular hyperfiltration. Data about renal function of adults with sickle cell disease have been reported, but data on children is scarce, especially when comparing heterozygotic and homozygotic patients. ObjectiveThe goal of this study was to investigate the glomerular filtration rate of heterozygotic and homozygotic children with sickle cell disease. MethodsThe glomerular filtration rate of 11 children with sickle cell disease [7 homozygotic (SS) and 4 heterozygotic (SC)] with a mean age of 11 years (standard deviation: ± 5 years) was evaluated using standard laboratory techniques. Results are presented as descriptive analysis. ResultsOur results suggest that glomerular hyperfiltration is present in children with sickle cell disease; this is more evident in homozygotic than heterozygotic children. ConclusionThere is evidence of a need to monitor the renal function of children with sickle cell disease when special attention should be paid to homozygotic patients.

Congolese children with sickle cell trait may exhibit glomerular hyperfiltration: A case control study

“…Hyperfiltration was present in 17% of children with Hb‐AS and in 30% of children with Hb‐SS. Different studies reported similar observations . The hyperfiltration may be caused by a polymerization of hemoglobin S in the renal medulla .…”

“…Different studies reported similar observations. [48][49][50] The hyperfiltration may be caused by a polymerization of hemoglobin S in the renal medulla. 42 However, these estimations have some limitations when compared with gold standard techniques.…”

Caracterización de las complicaciones renales en pacientes con anemia de células falciformes

“…La hiperfiltración glomerular se ha descrito como un marcador temprano de afectación renal, la cual contribuye al daño glomerular y al desarrollo de enfermedad renal. Entre los mecanismos fisiopatológicos se ha propuesto que la anemia crónica causa inicialmente vasodilatación renal con la consecuente hiperperfusión e hiperfiltración glomerular 8 , además de la polimerización de la Hb S en la médula renal 18 . Nosotros encontramos que el 59,3% de los pacientes presentaron hiperfiltración glomerular, similar a lo reportado por King y colaboradores (50,8%) 12 .…”

Renal involvement and its detection in sickle cell disease children

“…17 High mean GFR in early age has been reported by other authors also. 25,26 Estimated GFR is high most probably because of increased renal vasodilation due to chronic anemia leading to hyperperfusion and hyperfiltration. 27 Anigilage 28 and Aderibigbe 29 attributed finding of high GFR to error in urine collection and intravenous hydration which is a part of vaso-occlusive crisis management.…”