Red cell and human leukocyte antigen alloimmunization in candidates for renal transplantation: a reality

Mota, Márcia Maria Peruzzi Elia da

doi:10.5581/1516-8484.20130046

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…Human leukocyte antigen alloimmunization in candidates for renal transplantation is a reality [18] , [19] and knowledge of the incidence of sensitization to HLA antigens in the Brazilian population may be important for advances in renal transplantation and to minimize the waiting time for candidates [19] .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Humoral Immune Response to Human Leukocyte Antigens in Brazilian Renal Transplant Candidates

Saito

Yamakawa

Aparecida³

et al. 2014

PLoS ONE

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Pre-transplant sensitization to human leukocyte antigens (HLA) is a risk factor for graft failure. Studies of the immunological profile related to anti-HLA antibodies in Brazilian renal transplant candidates are few. In this study, we evaluated the humoral immune response to HLA antigens in 269 renal transplant candidates, in Paraná State, Brazil. The HLA typing was performed by the polymerase chain reaction sequence-specific oligonucleotide method (PCR-SSO) combined with Luminex technology, using an SSO-LABType commercial kit (One Lambda, Inc., Canoga Park, CA, USA). The percentages of panel-reactive antibodies (PRA) and the specificity of anti-HLA antibodies were determined using the LS1PRA and LS2PRA commercial kits (One Lambda, Inc.). The PRA-positive group consisted of 182 (67.7%) patients, and the PRA-negative group of 87 (32.3%) patients. The two groups differed significantly only with respect to gender. Females were the most sensitized. Among the 182 patients with PRA- positive, 62 (34.1%) were positive for class I and negative for class II, 39 (21.4%) were negative for class I and positive for class II, and 81 (44.5%) were positive for both classes I and II. The HLA-A*02, A*24, A*01, B*44, B*35, B*15, DRB1*11, DRB1*04 and DRB1*03 allele groups were the most frequent. The specificities of anti-HLA antibodies were more frequent: A34, B57, Cw15, Cw16, DR51, DQ8 and DP14. This study documented the profile of anti-HLA antibodies in patients with chronic renal failure who were on waiting lists for an organ in Paraná, and found high sensitization to HLA antigens in the samples.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Humoral Immune Response to Human Leukocyte Antigens in Brazilian Renal Transplant Candidates

Saito

Yamakawa

Aparecida³

et al. 2014

PLoS ONE

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“…The presence of HLA antibodies is associated with a greater risk of an early or last graft loss. 17 The high percentage of antibodies to class I and class II HLAs in her serum was the most likely contributor to the rejection of her first renal transplant. The patient did not require RBC transfusion after this evaluation, so further information about the management of her anti-At a in the pretransfusion or pretransplant setting is not available.…”

Section: Discussionmentioning

confidence: 98%

Anti-At^a in a renal transplant candidate: a case report

et al. 2020

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A patient with end-stage renal disease on chronic dialysis was admitted to the hospital for renal transplantation evaluation. Blood type and antibody detection tests were performed. The antibody detection test results were positive. Initial antibody identification studies indicated the presence of a panagglutinin. The patient's autocontrol was negative. The antibody was subsequently identified by a reference laboratory as anti-At a (Augustine), which is an extremely rare antibody due to the high prevalence of At a in the general population. A monocyte monolayer assay (MMA) was performed to assess the clinical significance of the antibody in the event that blood was needed for transfusion, and At(a-) RBCs were not available. The MMA results predicted the antibody to be capable of causing hemolysis in vivo. A brief historical review of the incidence and clinical significance of this antibody is included in this case report. Immunohematology 2020;36:104-107.

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“…However, it is associated with complications that include iron overload, infections, acute lung injury, anaphylaxis, and allo-immunization [3][4][5]. Alloimmunization is an immune response to foreign antigen following exposure to genetically different cells or tissues [6]. It depends on the number of blood transfusions received and the antigenic difference between the donor and the receiver.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Allo-Immunization in Sickle Cell Disease: Case of the Patients at the Laquintinie Hospital in Douala-Cameroon

Guegang¹,

Tuono²,

Fewou³

et al. 2022

EJCBS

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Background: Allo-immunization is an immune response to foreign antigens after exposure to genetically different cells or tissues. Allo-immunized patients with sickle cell disease (SCD) appear to experience worse survival compared to non allo-immunized patients. Therefore, to contribute to the management of patients living with SCD and improve the blood transfusion process, we aimed to determine the frequency of allo-immunization in SCD's patients. To realize this study, we carry out a cross sectional study in one Hospital of Douala-Cameroon. Method: Plasma was prepared from collected blood sample, electrophoresis was done and depending on the migration on the gel; the type of electrophoresis was determine. Blood group ABO/Rh was done. After electrophoresis, depending on the result obtained those that was not homozygote (SS) and heterozygote sickle cell anemia (AS) was discarded. The check for irregular agglutinins was done using the indirect Coombs test. Clinical and biological characteristics of the different participants were studied and analyzed using a Statview statistical software. Result: We obtained 104 sickle cell patient, out of these we had 55% of positive RAI, with an average transfusion of 7.35. Also 83 patients were homozygote sickle cell anemia for a mean age of 15.75 years old (ranging from 1 to 52 years). The result obtained shows that the number of blood transfusion for homozygote sickle cell patient increases with age and that homozygote sickle cell patient received more blood transfusion than heterozygote patient. It can also be said that allo-immunization in these patients originate from the multiple blood transfusion received that were not fully compatible and that it affects more children (from 1 -15), they accounted for about 53.85% of the total population. Our result obtained implies that in the future, sickle cell patient will have difficulty in finding compatible blood for treatment and is a real problem since transfusion is the major standard of care for patient suffering from sickle cell anemia in Cameroon. The absence of treatment may lead to the death of the patient. To help reduced allo-immunization, extended compatibility test in all the red blood cell system and routinely screening for the presence of irregulars agglutinins may reduce the frequency of allo-immunization.

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Red cell and human leukocyte antigen alloimmunization in candidates for renal transplantation: a reality

Cited by 7 publications

References 11 publications

Evaluation of the Humoral Immune Response to Human Leukocyte Antigens in Brazilian Renal Transplant Candidates

Evaluation of the Humoral Immune Response to Human Leukocyte Antigens in Brazilian Renal Transplant Candidates

Anti-At^a in a renal transplant candidate: a case report

Frequency of Allo-Immunization in Sickle Cell Disease: Case of the Patients at the Laquintinie Hospital in Douala-Cameroon

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Red cell and human leukocyte antigen alloimmunization in candidates for renal transplantation: a reality

Cited by 7 publications

References 11 publications

Evaluation of the Humoral Immune Response to Human Leukocyte Antigens in Brazilian Renal Transplant Candidates

Evaluation of the Humoral Immune Response to Human Leukocyte Antigens in Brazilian Renal Transplant Candidates

Anti-Ata in a renal transplant candidate: a case report

Frequency of Allo-Immunization in Sickle Cell Disease: Case of the Patients at the Laquintinie Hospital in Douala-Cameroon

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Anti-At^a in a renal transplant candidate: a case report