Blood donation, blood supply, iron deficiency and anemia - It is time to shift attention back to donor health

Cançado, Rodolfo Delfini; Langhi, Dante Mário

doi:10.5581/1516-8484.20120086

“…Iron stores are approximately 30% lower in female donors than in male donors who donate once in a year. This is in concordant with findings from studies in which ID is high in female blood donors than in male blood donors (Mahida et al 2008;Cancado et al 2001;Mittal et al 2006;Cancado and Laughi 2012). As a result, the female population was not included in this study due to the fact that only males were recruited into the GARIS, since the study targeted male healthy blood donors.…”

Section: )supporting

confidence: 86%

Prevalence of Iron Deficiency, Iron Deficiency Anaemia and General Anaemia in Male Gambian Blood Donors Residing in Greater Banjul Region

Dibbasey

¹

,

Lawal²,

Umukoro³

et al. 2021

Preprint

0

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ObjectiveThe objective of this study is to determine the prevalence of iron deficiency (ID) and iron deficiency anaemia (IDA) as well as general anaemia in male blood donors and their association with ageing process.Methodology and ResultsA total of two hundred and one (201) serum samples were analysed for ferritin in male Gambian blood donors. The ferritin measurement was achieved with COBAS® INTEGRA 400 plus. At the same time, haemoglobin values were retrospectively obtained from the archived haematological full blood count result in the GARIS database. IDA was defined as (Haemoglobin <13.0g/dL+ Ferritin<15ng/ml) whilst ID was defined as (Haemoglobin ≥13.0g/dL+ Ferritin<15ng/ml) and general anaemia was defined as haemoglobin <13.0g/dL in males. The prevalence of anaemia (20%, n=41), ID (22%, n=44) and IDA (10%, n=21), were recorded in male donors. The results show no relationship between ferritin and haemoglobin among the blood donors (collection coefficient (r) = 0.04). Besides, no linear association of having anaemia and ID with ageing was reported among the blood donor population.Conclusion and potential application of findingsID and IDA as well as general anaemia are highly prevalent among blood donors in the Gambia. Besides, no predisposition to ID and anaemia was observed in term of age, thus all blood donors from 18-60 should be considered for blood donation without any age preference.

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“…Significant amounts of iron are lost from the body through blood donation, while the capacity to store and replace it from food is limited . The greatest risk of increased frequency of blood donation is consequently iron deficiency and a fall in haemoglobin (Hb) levels .…”

Section: Introductionmentioning

confidence: 99%

“…Significant amounts of iron are lost from the body through blood donation, while the capacity to store and replace it from food is limited . The greatest risk of increased frequency of blood donation is consequently iron deficiency and a fall in haemoglobin (Hb) levels . Limits on frequency of donation exists primary to protect donor health, however, there is no internationally agreed optimum interval between donations, and blood donation services in different countries have adopted different policies.…”

Section: Introductionmentioning

confidence: 99%

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Donor understandings of blood and the body in relation to more frequent donation

Lynch

¹

,

Cohn

²

2018

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“…This probably reflects the effect of the blood donation that took place between the control and transfusion phases. It is well-known that blood donation depletes the donor of blood components, including a significant amount of iron in the RBCs (about 200-240 g) [28,29]. Indeed, several studies show that ferritin levels drop by about 50% after blood donation and that this effect worsens with frequent donation [30,31].…”

Section: Research Articlementioning

confidence: 99%

Hepcidin as a new biomarker for detecting autologous blood transfusion

Leuenberger

¹

,

Barras

²

,

Nicoli

³

et al. 2016

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Autologous blood transfusion (ABT) is an efficient way to increase sport performance. It is also the most challenging doping method to detect. At present, individual follow-up of haematological variables via the athlete biological passport (ABP) is used to detect it. Quantification of a novel hepatic peptide called hepcidin may be a new alternative to detect ABT. In this prospective clinical trial, healthy subjects received a saline injection for the control phase, after which they donated blood that was stored and then transfused 36 days later. The impact of ABT on hepcidin as well as haematological parameters, iron metabolism, and inflammation markers was investigated. Blood transfusion had a particularly marked effect on hepcidin concentrations compared to the other biomarkers, which included haematological variables. Hepcidin concentrations increased significantly: 12 hr and 1 day after blood reinfusion, these concentrations rose by seven-and fourfold, respectively. No significant change was observed in the control phase. Hepcidin quantification is a cost-effective strategy that could be used in an "ironomics" strategy to improve the detection of ABT.

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Blood donation, blood supply, iron deficiency and anemia - It is time to shift attention back to donor health

Cited by 5 publications

References 9 publications

Prevalence of Iron Deficiency, Iron Deficiency Anaemia and General Anaemia in Male Gambian Blood Donors Residing in Greater Banjul Region

Prevalence of Iron Deficiency, Iron Deficiency Anaemia and General Anaemia in Male Gambian Blood Donors Residing in Greater Banjul Region

Donor understandings of blood and the body in relation to more frequent donation

Hepcidin as a new biomarker for detecting autologous blood transfusion

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