Dengue antibodies in blood donors

Abstract

BackgroundDengue is an urban arbovirus whose etiologic agent is a virus of the genus Flavorius with four distinct antigen serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) that is transmitted to humans through the bite of the mosquito Aedes aegypti. The Campo Mourão region in Brazil is endemic for dengue fever.ObtectiveThe aim of this study was to evaluate the presence of IgG and IgM antibodies specific to the four serotypes of dengue in donors of the blood donor service in the city of Campo Mourão.MethodsEpidemiological records were evaluated and 4 mL of peripheral blood from 213 blood donors were collected in tubes without anticoagulant. Serum was then obtained and immunochromatographic tests were undertaken (Imuno-Rápido Dengue IgM/IgGTM). Individuals involved in the study answered a social and epidemiological questionnaire on data which included age, gender and diagnosis of dengue.ResultsOnly three (1.4%) of the 213 blood tests were positive for IgG anti-dengue antibodies. No donors with IgM antibody, which identifies acute infection, were identified.ConclusionsThe results of the current analysis show that the introduction of quantitative or molecular serological methods to determine the presence of anti-dengue antibodies or the detection of the dengue virus in blood donors in endemic regions should be established so that the quality of blood transfusions is guaranteed.

Dengue viremia in blood donors in Northern India: Challenges of emerging dengue outbreaks to blood transfusion safety

“…Data of this study showed predominance of male donors (98.3%) over female donors (1.70%) with the majority of donors (76.18%) of <35 years age group. These findings are similar to findings of Ribas-Silva and Andressa[ 7 ] who reported 63.8% of male donors with 30% of donors within 30-39 years age group.…”

Dengue virus infections among blood donors in Guangxi of China, 2013–2014

“…The reason for this low IgG‐positive rate may be: (1) the number of blood donors with dengue infection in this area was previously lower; (2) it maybe caused by the recent DENV outbreak in the neighbouring area, and the virus had just started to spread in Liuzhou during that time; and (3) the sample size may be not large enough. Although these rates are much lower than those reported in donors in the Guangdong Province during the severe dengue outbreak in 2014 and other Southeast Asian countries (Harif et al ., ; Low et al ., ), the geographical features of Guangxi and its closeness to the surrounding dengue seasonal endemic regions may make it vulnerable to future outbreaks (Dias et al ., ; Ribas‐Silva & Eid, ).…”

Seroprevalence and factors associated with IgG anti‐DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply

“…19,20 Viraemic donor rate may be as high as 0.4% during outbreaks, 21 with a risk of transfusion-transmitted DENV (TT-DENV) calculated as 1 in 1300 donations in Puerto Rico. 22 Questions on the potential transmission of DENV by transfusion increased after the documentation of the risk of transmission of the West Nile virus (WNV) by Biggerstaff & Petersen 23 and Biggerstaff & Petersen. 24 It seems highly probable that DENV is transmitted in a manner similar to the WNV as both are arboviruses within the same family of Flaviviridae.…”

“…The asymptomatic and subclinical cases, estimated at around 50‐85% of DENV infections, constitute the main concern regarding transfusion safety as symptomatic cases are assumed to be rejected at the pre‐donation screening Previous studies reported the presence of DENV in blood donors in Honduras, Brazil, Australia, Puerto Rico and Saudi Arabia . Viraemic donor rate may be as high as 0.4% during outbreaks, with a risk of transfusion‐transmitted DENV (TT‐DENV) calculated as 1 in 1300 donations in Puerto Rico …”