Dengue

Abstract

AimThe objective of this study was to correlate laboratory tests during the evolution of dengue fever, comparing frequencies between the different clinical forms in order to use test results to predict the severity of the disease.MethodsThis is an observational, descriptive and retrospective study of 154 patients with clinical and serological diagnoses of dengue fever who, in the period from January to May 2008, were admitted in a tertiary state hospital in the city of Fortaleza that is a referral center for infectious diseases. The patients were allocated to two groups according to age: under 15 years old (n = 66) and 15 years or older (n = 88). The tests analyzed were blood count, platelet count, and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations.ResultsThrombocytopenia and elevated transaminases were observed in patients with classic dengue fever. The main laboratory abnormalities found in dengue hemorrhagic fever were thrombocytopenia, hemoconcentration and elevated transaminases, similar to severe dengue with the exception of hemoconcentration. Most laboratory abnormalities started on the 3rd day but were more evident on the 5th day with restoration of values by the 11th day; this was more prominent in under 15-year-olds and with the more severe clinical forms.ConclusionThese results are relevant in assessing the disease because they can be used as markers for more severe forms and can help by enabling the adaptation of the therapeutic conduct to the needs of individual patients.

Hematological Parameters in Dengue: The Serological Angle A Study

“…In contrast, normal counts were noted more (48%) in the antibody pattern rather than NS1 antigen pattern (22%). Our study indicated that leucocytosis was a later event mostly associated with antibody & none with NS1 antigen, in contrast to few studies which claimed it was an early event [13] .…”

“…Our study focusses on the utility of these hematology parameters including platelet counts, but where platelet count is not an early indicator of dengue [1] , the total leucocyte counts-leucopenia & lymphocytosis are earlier and prominent events in dengue [13] along with haematocrit in resource limited rural set ups [14] .…”

Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques

“…[34] Higher elevations of liver aminotransferase were observed in IMF and ID +SGE compared to SC and ID groups Thrombocytopenia, leukopenia, decreases in lymphocyte, monocyte, and neutrophil counts, elevated percent monocytes, and elevated levels of aminotransferases are considered biological hallmarks of dengue fever (DF) in humans. [2][3][4][5]65] To determine if these hematologic and serum chemistry parameters were impacted by infection modality, we evaluated blood and serum samples collected before, during, and after primary DENV-1 infection (days 0, 7, 21; � primary DENV2 infection controls for the SC injection and IMF methods †DENV-1 strain 0111/2011; DENV-2 strain 0126/2010 # IMF animals were exposed to the probing and/or feeding of 15 mosquitoes each; details of the inoculum are available in the "Materials and Methods" and in S4 Table. SC = subcutaneous; ID = intradermal; SGE = salivary gland extract; IMF = infectious mosquito feeding; SGeq = salivary gland equivalents in PBS https://doi.org/10.1371/journal.pntd.0008191.t001…”

Case of Near Fatal Massive Intracerebral Bleed Secondary to Cerebral Venous Thrombosis in a Patient with Dengue and Refractory Thrombocytopenia

“…It usually starts on day 3rd of fever while starts improving beyond 8th-10th day. [6][7][8] The mechanisms involved in thrombocytopenia in dengue are not fully understood and several hypotheses have been suggested to elucidate it. 4,[9][10][11] Our patient continued to have low platelet counts in the 3rd week of her illness which was refractory to any transfusion.…”