Determinação Dos Níveis Séricos De Proteína C-Reativa (Crp) Em Cães Com Alterações Dos Parâmetros Hematológicos

Anziliero, Deniz; Bassi, Eduarda; Pain, Katrin Macedo; Valle, Stella de Faria; Kreutz, Luiz Carlos

doi:10.5216/cab.v14i2.9054

Cited by 3 publications

(5 citation statements)

References 23 publications

(25 reference statements)

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“…It is known that CRP rises more intensely in cases of inflammation, neoplasms and autoimmune diseases. (Anziliero et al 2013, Venco et al 2014, Liu et al 2015. In dogs, the half-life of only six hours causes the serum concentration to normalize rapidly, between one to two days after the lesion ends (Michelsen et al 2012, Rubio & Schmidt 2014, Reimann et al 2016.…”

Section: Tabela 6 Analysis Of Correlations Between C-reactive Proteimentioning

confidence: 99%

“…LoS = Length of hospital stay, CRP = C-reactive protein, CAR = C-reactive protein/albumin ratio; a,b,c = equal letters indicate that the variables compared do not differ statistically, while distinct letters indicate a significant difference by the Kruskal-Wallis test at 5%. Reference values: albumin = 2.6 to 3.3g/ dL (Thrall et al 2015), CRP = <5,0-8,70μg/mL (Kuribayashi et al 2003, Kaya et al 2012, Anziliero et al 2013. a CRP = C-reactive protein, b LoS = length of hospital stay, c CAR = C-reactive protein/albumin ratio.…”

Section: Severity Of Underlying Diseasementioning

confidence: 99%

“…As a prognostic marker in companion animals, C-reactive protein is especially useful because its increase precedes any leukocyte alteration, enabling the recognition of subclinical disorders (Anziliero et al 2013, Karlsson et al 2013, Viitanen et al 2014. High serum concentrations have been associated with a higher death rate in dogs, with normalizing being associated with clinical recovery (Michelsen et al 2012, Anziliero et al 2013, McClure et al 2013.…”

Section: Introductionmentioning

confidence: 99%

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Determination of the reference interval of the C-reactive protein/albumin ratio and its efficiency, CRP and albumin as prognostic markers in dogs

et al. 2020

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The objective of this research was to creates a reference interval for C-reactive protein (CRP)/albumin ratio (CAR) in the canine species and to analyze the potential of CRP, albumin and the relationship between both, to serve as indicators of disease severity, length of hospital stay (LoS) and mortality in this species. For this, an outcome study was conducted in a Veterinary Teaching Hospital in southern Brazil. One hundred ninety dogs were included randomly, without distinction of gender, age, or breed, from June 2013 to November 2016. Plasma was collected from them and analyzed for assessment of CRP and albumin. The reference range stipulated for CAR in dogs was 0.36-0.60, as determined by the confidence interval of mean resamplings (in percentiles). The frequencies mean, and standard deviations of the variables, correlation analysis, and comparative analysis (Kruskal-Wallis in α = 5%) were calculated. Elevation (above reference) of CAR was determined to be proportional to the severity of the underlying disease, and CRP means were reasonable. Besides, hypoalbuminemia was indicative of systemic disease, but not of severity. Thus, CAR was a better marker of disease severity than were CRP and albumin, analyzed separately. Concerning LoS, there was a positive correlation with CAR (p<0.01) in patients, and the same was not observed with CRP and albumin. Concerning mortality, hypoalbuminemia was the only marker valid in animals with a critical illness (p=0.04). In conclusion, CAR is a better marker of disease severity and LoS in dogs than are CRP and albumin analyzed separately.

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Section: Tabela 6 Analysis Of Correlations Between C-reactive Proteimentioning

confidence: 99%

Section: Severity Of Underlying Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determination of the reference interval of the C-reactive protein/albumin ratio and its efficiency, CRP and albumin as prognostic markers in dogs

et al. 2020

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“…There are few studies in humans describing the correlation between the CRP/ albumin and NS ratio and, to our knowledge, this relationship has not yet been studied in dogs. This is probably due to increased muscle catabolism, increased serum CRP concentration, and reduced albumin in inflammatory conditions (as these were sick animals), these processes could be aggravated by protein malnutrition (Richards et al, 2012;Anziliero et al, 2013;Wong et al, 2016).…”

Section: Groupmentioning

confidence: 99%

Laboratory profile of malnutrition in hospitalized dogs

Fabretti¹,

Siqueira²,

Amaral³

et al. 2021

Semina: Ciênc. Agrár.

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Malnutrition occurs when the supply of available nutrients is less than organic demand. It is an underdiagnosed problem in veterinary medicine and can result in several negative metabolic consequences, with greater morbidity and mortality. Currently, the classification of nutritional status (NS) is performed subjectively in veterinary medicine, so studies and discoveries about laboratory markers (objectives) of malnutrition are desirable. This study evaluated the correlations between several laboratory variables (practical and low-cost measurements) and the nutritional status (NS) of 246 dogs from a veterinary school hospital in southern Brazil. In this way, the laboratory profile of malnutrition in this population is evident. NS was classified by body condition score (BCS) and muscle mass score (MMS). A patient was considered to be malnourished if the BCS was less than 3 (values from 1 to 9). The laboratory variables analyzed were hemogram, cholesterol, total protein (TP), albumin, C-reactive protein (CRP), CRP/albumin ratio, total iron-binding capacity (TIBC), transferrin (TF), transferrin saturation index (TSI), and transthyretin. The means and standard deviations of the variables, correlation analyses, and comparative analyses (Kruskal-Wallis in α = 5%) were calculated. This research aimed to identify objective and practical malnutrition markers that help in the elaboration of a protocol for nutritional evaluation in diseased dogs. Low values of TF, TIBC, TP, hemogram, and TSI elevation were indicative of malnutrition. Additionally, cholesterol and albuminemia are not good markers of malnutrition in dogs with systemic diseases. For the graduation of the inflammatory state (important to differentiate inflammatory hypoproteinemia from protein malnutrition), it is more reliable to measure the CRP/albumin ratio. Canine transthyretin cannot be measured with reagents designed for humans, such as those used in this study. It was possible to conclude that laboratory indicators of malnutrition in sick dogs include low values of TF, TIBC, and TP, anemia, and elevations of TSI. The joint changes in these markers gradually reinforced the diagnosis.

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“…Várias doenças em caninos acarretam aumento nos níveis séricos de PCR como, por exemplo, leptospirose, parvovirose, babesiose, também ocorre em tumores (linfoma e hemangiossarcoma) e traumas cirúrgicos, além de pancreatite aguda, anemia imunomediada, artrite, glomerulonefrite e processos inflamatórios experimentais (Nakamura et al, 2008, Anziliero et al, 2013.…”

Section: Introductionunclassified

Avaliação da resposta inflamatória sistêmica induzida por carcinoma ductal in situ em cadelas

Braz

Sartoretto

Lima

et al. 2018

Pubvet

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RESUMO. Em tumores mamários, é comum alterações inflamatórias, causadas principalmente em neoplasias que metastatizam. Este trabalho tem por objetivo avaliar a concentração de Proteína C Reativa (PCR), correlacionada as alterações de proteínas totais e albumina em cadelas com carcinoma ductal in situ e demonstrar as alterações hematológicas encontradas. Foram utilizadas 13 cadelas diagnosticadas com carcinoma ductal in situ, triados pelo exame citopatológico e confirmado pela histopatologia. Concluise que a PCR é uma proteína de fase aguda que se eleva independente das proteínas totais e albumina e as alterações hematológica são de pouca relevância para o diagnóstico de carcinoma ductal in situ.Palavras chave: proteínas de fase aguda, inflamação, tumor mamário canino, biomarcadores Evaluation of systemic inflammatory response induced by ductal carcinoma in situ in dogs ABSTRACT. In breast tumors, inflammatory changes are common, mainly caused by neoplasias that metastasize. This work aims to evaluate the concentration of C Reactive Protein (CRP), correlating the alterations of total proteins and albumin in dogs with ductal carcinoma in situ and to demonstrate the hematological alterations found. Thirteen dogs diagnosed with ductal carcinoma in situ were screened by cytopathological examination and confirmed by histopathology. It is concluded that CRP is an acute phase protein that rises independently of total proteins and albumin and hematological changes are of little relevance for the diagnosis of ductal carcinoma in situ.Keywords: acute phase proteins, inflammation, canine mammary tumor, biomarkers Evaluación de la respuesta inflamatoria sistémica inducida por carcinoma ductal in situ en perras RESUMEN. En tumores mamarios, es común alteraciones inflamatorias, causadas principalmente en neoplasias que hacen metástasis. Este trabajo tiene por objetivo evaluar

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Determinação Dos Níveis Séricos De Proteína C-Reativa (Crp) Em Cães Com Alterações Dos Parâmetros Hematológicos

Cited by 3 publications

References 23 publications

Determination of the reference interval of the C-reactive protein/albumin ratio and its efficiency, CRP and albumin as prognostic markers in dogs

Determination of the reference interval of the C-reactive protein/albumin ratio and its efficiency, CRP and albumin as prognostic markers in dogs

Laboratory profile of malnutrition in hospitalized dogs

Avaliação da resposta inflamatória sistêmica induzida por carcinoma ductal in situ em cadelas

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