Screening the fluid bed granulation process variables and moisture content determination of pharmaceutical granules by NIR Spectroscopy

Abouzaid, Ahmed Shawky; Salem, Maissa Y.; Elzanfaly, Eman S.; Gindy, Ahmed Emad El; Hoag, Stephen W.; Ibrahim, Ahmed

doi:10.5155/eurjchem.8.3.265-272.1608

Cited by 3 publications

(1 citation statement)

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“…Fluid bed granulation (FBG) is a process widely used in the pharmaceutical industry to manufacture solid dosage products and its importance to the industry has resulted in it being extensively studied over the last few decades [1][2][3]. During an FBG unit operation, size enlargement of circulating primary powder particles takes place within the fluid bed chamber due to the wetting of particles by the sprayed binder solution and the resulting collisions between wetted particles.…”

Section: Introduction and Objectivesmentioning

confidence: 99%

Model Development and Validation of Fluid Bed Wet Granulation with Dry Binder Addition Using a Population Balance Model Methodology

et al. 2018

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An experimental study in industry was previously carried out on a batch fluid bed granulation system by varying the inlet fluidizing air temperature, binder liquid spray atomization pressure, the binder liquid spray rate and the disintegrant composition in the formulation. A population balance model framework integrated with heat transfer and moisture balance due to liquid addition and evaporation was developed to simulate the fluid bed granulation system. The model predictions were compared with the industry data, namely, the particle size distributions (PSDs) and geometric mean diameters (GMDs) at various time-points in the granulation process. The model also predicted the trends for binder particle dissolution in the wetting liquid and the temperatures of the bed particles in the fluid bed granulator. Lastly, various process parameters were varied and extended beyond the region studied in the aforementioned experimental study to identify optimal regimes for granulation.

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Section: Introduction and Objectivesmentioning

confidence: 99%