Heteroaromatization with 4-phenyldiazenyl-1-naphthol. Part II: Synthesis of some new benzochromens, benzochromenopyrimidines, benzochromenotriazolopyrimidines, benzochromenopyrimidotriazepine and antimicrobial activities

Radini, Ibrahim Ali M.; Hamed, Hany Mostafa; Kharir, Mohammed Abdo Yahya; El‐Wahab, Ashraf Hassan Fekry Abd

doi:10.5155/eurjchem.8.3.240-247.1599

Eur. J. Chem.

2017

DOI: 10.5155/eurjchem.8.3.240-247.1599

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Heteroaromatization with 4-phenyldiazenyl-1-naphthol. Part II: Synthesis of some new benzochromens, benzochromenopyrimidines, benzochromenotriazolopyrimidines, benzochromenopyrimidotriazepine and antimicrobial activities

Ibrahim Ali M. Radini

Hany Mostafa Hamed

Mohammed Abdo Yahya Kharir

et al.

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Cited by 2 publications

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Anti-cancerous Properties of the Synthesized Substituted Chromene Compounds and their Pharmacological Activities

Abdelwahab

Fekry

2023

LDDD

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Introduction: 2-Amino-7-hydroxy-4-phenyl-4H-chromene-3-carbonitrile (4) was synthesized through three-component reaction in ethanol/piperidine solution. Methods: Synthesis of several new 4H-chromenes (5-14) has been achieved involving various reactions. The structure of these new compounds was confirmed using IR, 1H NMR and 13C NMR, as well as MS spectroscopy. Results and Conclusion: All newly substituted chromene derivatives display potential analgesic and anticonvulsant activities. The structure activity relationship study revealed that 2-amino-4-phenyl-3-(1H-tetrazol-5-yl)-4H-chromen-7-ol (13) was more beneficial than 8-hydroxy-2-methyl-5-phenyl-3,5-dihydro-4H-chromeno[2,3-d]pyrimidin-4-one (11), 8-hydroxy-2,5-diphenyl-3,5-dihydro-4H-chromeno[2,3-d]pyrimidin-4-one (12), and 8-hydroxy-5-phenyl-3,5-dihydro-4H-chromeno[2,3-d]pyrimidin-4-one (14) for analgesic and anti-inflammatory activities.

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Anti-cancerous Properties of the Synthesized Substituted Chromene Compounds and their Pharmacological Activities

Abdelwahab

Fekry

2023

LDDD

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Efficient Synthesis of Novel Spiro[indoline-3,5'-pyrano[2,3-d]pyrimidin]-2-one Derivatives and Antitumor Activity Evaluation

Li¹,

Rong²,

Cao³

et al. 2022

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Heteroaromatization with 4-phenyldiazenyl-1-naphthol. Part II: Synthesis of some new benzochromens, benzochromenopyrimidines, benzochromenotriazolopyrimidines, benzochromenopyrimidotriazepine and antimicrobial activities

Cited by 2 publications

References 41 publications

Anti-cancerous Properties of the Synthesized Substituted Chromene Compounds and their Pharmacological Activities

Anti-cancerous Properties of the Synthesized Substituted Chromene Compounds and their Pharmacological Activities

Efficient Synthesis of Novel Spiro[indoline-3,5'-pyrano[2,3-d]pyrimidin]-2-one Derivatives and Antitumor Activity Evaluation

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