Oxonium heterocyclic quinone in the synthesis of some cyanine dyes and their antimicrobial activity

Gomaa, Maha Mobaruk

doi:10.5155/eurjchem.5.3.463-468.973

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Procedure for the synthesis of 5- ((3-acetyl-1,4-dioxo-1,4-dihydronaphthalen-2yl) diazenyl)-2-hydroxybenzaldehyde (3) Compound (1) (2-acetyl-3-aminonaphthalene-1, 4-dione(1)) and diazonium salt (2) were synthesized according to previous methods [40][41][42].…”

Section: Chemistrymentioning

confidence: 99%

Antioxidant, Antimicrobial, and Molecular Docking Studies of Novel 1, 4-naphthoquinone Derivatives

Elkanzi

Hrichi

2021

Preprint

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The synthesis of novel 1,4-naphthoquinone derivatives has attracted prominent interest in the field of medicinal chemistry since these compounds exhibit potent pharmacological activity as antibacterial, antioxidant, antifungal, and anticancer. Herein, a series of novel 1,4-naphthoquinone derivatives 4-7, 8a-c, and 9a-d containing heterocyclic moieties were synthesized in good yields and characterized by spectral and elemental analyses. All the new synthesized compounds were subjected to in-vitro antimicrobial testing against gram-positive, gram-negative, and fungal strains by calculating the average of the zone of inhibition. The antimicrobial results showed that compounds 8b, 9b, and 9c displayed the highest efficacy against both bacterial and fungal strains. Further studies have been conducted to estimate the antioxidant activity of the compounds using DPPH scavenging assay. The obtained results revealed that compounds 9d, 9a, 9b, 8c, and 6 exhibited the highest radical scavenging activity. Docking studies of the most active antimicrobial compounds within GLN- 6-P, recorded good scores with several binding interactions with the active site.

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Section: Chemistrymentioning

confidence: 99%

Antioxidant, Antimicrobial, and Molecular Docking Studies of Novel 1, 4-naphthoquinone Derivatives

Elkanzi

Hrichi

2021

Preprint

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“…E is the potential for reduction and is the transfer Coefficient we take for better results. [30][31][32][33][34][35][36][37][38][39][40][41][42][43] When we using scan the reduced species at silver working electrode (SWE) is oxidation back to return to the starting. If reaction proceeds reversibly, the peak potential Separation ΔEp will be near .58/n (at 25˚C .…”

Section: Analysis Of Voltammograms Obtainedmentioning

confidence: 99%

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et al. 2019

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Redox reaction mechanism in absence and presence of Valporic Acid (VaA) was studied in cyclic voltammetry, we used a new silver electrode made from pure Silver piece jointed to copper wire and isolated by heat shrink polymer to insure Complete isolation, during measurements. The Silver electrode was polished with Al 2 O 3 in woolen piece, washed and used for the cyclic voltammetric Study. The stability constants and Gibbs free energies of complex reactions between HgCl 2 and Valproic acid (VaA) in 0.01 M KNO 3 at 22˚C were evaluated and their results were discussed.

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Antioxidant, Antimicrobial, and Molecular Docking Studies of Novel Chalcones and Schiff Bases Bearing 1, 4-naphthoquinone Moiety

Elkanzi

Hrichi

Bakr

2022

LDDD

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Background: The 1,4-naphthoquinone ring has attracted prominent interest in the field of medicinal chemistry due to its potent pharmacological activity as antioxidant, antibacterial, antifungal, and anticancer. Objective: Herein, a series of new Schiff bases (4-6) and chalcones (8a-c & 9a-d) bearing 1,4-naphthoquinone moiety were synthesized in good yields and were subjected to in-vitro antimicrobial, antioxidant, and molecular docking testing. Methods: A facile protocol has been described in this study for the synthesis of new derivatives (4-7, 8a-c, and 9a-d) bearing 1,4-naphthoquinone moiety. The chemical structures of all the synthesized compounds were identified by 1H-NMR, 13C-NMR, MS, and elemental analyses. Moreover, these derivatives were assessed for their in-vitro antimicrobial activity against gram-positive, gram-negative bacteria, and fungal strains. Further studies were conducted to test their antioxidant activity using DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging assay. Molecular docking studies were realized to identify the most likely interactions of the novel compounds within the protein receptor. Results: The antimicrobial results showed that most of the compounds displayed good efficacy against both bacterial and fungal strains. The antioxidant study revealed that compounds 9d, 9a, 9b, 8c, and 6 exhibited the highest radical scavenging activity. Docking studies of the most active antimicrobial compounds within GLN- 6-P, recorded good scores with several binding interactions with the active sites. Conclusion: Based on the obtained results, it was found that compounds 8b, 9b, and 9c displayed the highest activity against both bacterial and fungal strains. The obtained findings from the DPPH radical scavenging method revealed that compounds 9d and 9a exhibited the strongest scavenging potential. The molecular docking studies proved that the most active antimicrobial compounds 8b, 9b and 9c displayed the highest energy binding scores within the glucosamine-6-phosphate synthase (GlcN-6-P) active site.

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Oxonium heterocyclic quinone in the synthesis of some cyanine dyes and their antimicrobial activity

Cited by 3 publications

References 32 publications

Antioxidant, Antimicrobial, and Molecular Docking Studies of Novel 1, 4-naphthoquinone Derivatives

Antioxidant, Antimicrobial, and Molecular Docking Studies of Novel 1, 4-naphthoquinone Derivatives

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Antioxidant, Antimicrobial, and Molecular Docking Studies of Novel Chalcones and Schiff Bases Bearing 1, 4-naphthoquinone Moiety

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