Synthesis and characterization of novel heterocycles based on tetrazine and hydrazonoyl halides

Synthesis of Pyrazolyl‐Pyrazoles and Pyrazolyl‐[1,2,4]‐Triazolo[3,4‐d][1,5]Benzothiazepines as p53 Activators Using Hydrazonoyl Chlorides

“…In continuation of our previous work in synthesis of bioactive pyrazoles from hydrazonoyl halides , we synthesized di ‐pyrazoles 4 or its isomeric structure 5 via 1,3‐dipolar cycloaddition of nitrile imine 2 (generated in situ from hydrazonoyl halides 1 in dry benzene in the presence of a catalytic amount of triethylamine) to the chalcone derivative 3 (Scheme ). The spectral data of the isolated products indicated that they have structure 4 rather than the isomeric structure 5 .…”

Synthesis, Characterization and Biological Evaluation of Novel Thiadiazoline Sulfonamides and Metal Complexes

“…Chemistry: In continuation of our studies of hydrazonoyl halides and their reaction (Sayed et al, 2014), we treatment of 1-{chloro(pyridine-2-yl)methylene}-2-phenylhydrazine 4b with thiourea 5 in ethanol under heating gave a single isolated 3-phenyl-5-(pyridine-2-yl)-1, 3, 4-thiadiazol-2(3H) imine 7 via elimination of HBr and ammonia, as shown in Fig. 2.…”

“…The chemistry of hydrazonoyl halides has attracted wide interest due to their ability to undergo a wide variety of reactions that provide routes to a myriad of both heterocyclic and acyclic compounds (Sayed et al, 2014). In addition, diverse biologic activities, such as antiviral, antiarthropodal, antimicrobial, fungicidal, herbicidal, insecticidal, pesticidal, acaricidal and miticidal are associated with hydrazonoyl halides (Shawali, 2010;Kaugaris, 1972;Buzykin et al, 1981;Kukota et al, 1978;Strinadkin et al, 1985;Noguchi et al, 1973;Tozer et al, 1999).…”

A review on bis-hydrazonoyl halides: Recent advances in their synthesis and their diverse synthetic applications leading to bis-heterocycles of biological interest

“…Reaction of the bis -hydrazonoyl chloride IV with bicyclo[2.2.1]hept-2-ene in refluxing dimethylformamide in the presence of triethylamine yielded the bis -cycloadduct 56 in 71% yield ( Scheme 33 ) [47] .…”