Synthesis of some transition metal complexes of novel 1-methylpyrazole-3-aldehyde-4-(2-pyridyl) thiosemicarbazone: Spectroscopic and in vitro biological activity studies

Al-Jahdali, Mutlaq; Elmalik, Yahia Hassan; El‐Reash, G.M. Abu

doi:10.5155/eurjchem.5.2.201-208.952

Cited by 4 publications

(3 citation statements)

References 63 publications

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“…4-(2-Pyridyl)-3-thiosemicarbazone and Au(tht)Cl were prepared by literature procedures. , All other reagents were supplied from commercial sources and used as received. Elemental (C, H, and N) analyses were measured on a Carlo-Erba CHNO–S microanalyzer.…”

Section: Methodsmentioning

confidence: 99%

One-Dimensional Heterobimetallic Au/Ag Coordination Polymer Showing a Selective, Reversible, and Visible Vapor-Chromic Photoluminescent Response toward Methanol

et al. 2023

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A heterobimetallic coordination polymer [Au 4 (dppmt) 4 (AgCl) 2 ] n (1) incorporating an in situ generated P−S ligand (dppmtH) was synthesized from the solvothermal reaction of Au(tht)Cl, AgCl, and dpppyatc in CH 3 CN/CH 2 Cl 2 (dppmtH = (diphenylphosphino)methanethiol, tht = tetrahydrothiophene, dpppyatc = N,N-bis-((diphenylphosphaneyl)methyl)-N-(pyridin-2-yl)-amino-thiocarbamide). The structure of 1 contains a one-dimensional helical Au−Au chain in which the unique [Au 4 Ag 2 S 2 ] cluster units are connected by [Au 2 (dppmt) 2 ] dimers. Upon excitation at 343 nm, 1 exhibited cyan (495 nm) phosphorescent emission at quantum yield (QY) = 22.3% and τ = 0.78 μs (λ ex = 375 nm). Coordination polymer 1 exhibited a rapid, selective, reversible, and visible vaporchromic response on exposure to methanol (MeOH) vapor with its emission shifting to a more intense green (530 nm, λ ex = 388 nm) with QY = 46.8% and τ = 1.24 μs (λ ex = 375 nm). A polymethylmethacrylate film containing 1 served as a reversible chemical sensor for the sensitive detection of MeOH in air.

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Section: Methodsmentioning

confidence: 99%

One-Dimensional Heterobimetallic Au/Ag Coordination Polymer Showing a Selective, Reversible, and Visible Vapor-Chromic Photoluminescent Response toward Methanol

et al. 2023

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“…These complexes may be employed in photo‐redox processes or can be prospective therapeutic agents [14] . Riboflavin, tyrosine, arginine, bipyridyl, and phenyl‐acetic acid have been used as primary ligands to synthesize a variety of mixed ligand complexes that have shown excellent antibacterial activity [15] . Mixed ligand complexes of 2‐butanone thiosemicarbazone and 1,10‐phenanthroline have also been investigated for their anticancer and antibacterial activities [16] .…”

Section: Introductionmentioning

confidence: 99%

“…[14] Riboflavin, tyrosine, arginine, bipyridyl, and phenyl-acetic acid have been used as primary ligands to synthesize a variety of mixed ligand complexes that have shown excellent antibacterial activity. [15] Mixed ligand complexes of 2-butanone thiosemicarbazone and 1,10-phenanthroline have also been investigated for their anticancer and antibacterial activities. [16] Cu(II), Ni(II) and Co(II) complexes of 2-(1-(2-phenyl-hydrazono)-propan-2ylidene)hydrazine-carbothioamide (TPHP) and 1,10-phenanthroline have been synthesized and it was found that the MÀ Cl bond length was shorter than that of MÀ S in the complexes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization,Computational Studies and Antimicrobial activity evaluation of Mixed ligand‐Metal complexes of selected thiosemicarbazones

Khan,

Zehra,

Alvi

et al. 2024

ChemistrySelect

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The current work reports the synthesis of mixed ligand‐metal complexes of (2‐(2‐oxoacenaphthylen‐1 ylidene)hydrazinecarbothioamide) (L1) and carbamothioyl‐2‐chloronicotinohydrazonic acid (L2) and imidazole (im), triphenylphosphine (PPh3) and pyridine (py) ligands with Cu (II), Zn (II), Fe (II) and Co (II) salts.The chacterization was done through FT‐IR, NMR, UV‐visible, and elemental analysis. The X‐ray diffraction (XRD) patterns of [Cu(L1)(im)2(SO4)] demonstrated the crystalline morphology. In the FT‐IR spectra of the ligands, the characteristic frequencies corresponding to ν(C=N) (imine) and ν(C=S) (thiocarbonyl) were observed around 1650 and 1130 cm−1 respectively, which shifted upon complexation. In the 1H NMR spectra, the peak due to the NH proton was observed downfield, whereas that of ‐NH2 was observed comparatively upfield owing to its secondary amine nature. The molecular docking was performed against transforming growth beta (tgf‐β), protease of SARS‐CoV‐2 (Mpro) and aspartate kinase (Asp) kinase.The molecular simulation with the docked complex of [Zn(L2)(py)2(SO4)] and [Zn(L1)(PPh3)2(SO4)] with Asp kinase showed significant stability during the simulation time of 100 ns. The relative free energies of the simulated complexes were calculated with the molecular mechanics Poison‐Boltmann surface area (MM‐PBSA). The complexes were tested against ten bacterial strains and showed enhanced antibacterial activity than the ligands. [Cu(L1)(im)2(SO4)], [Zn(L1)(im)2(SO4)], [Fe(L1)(im)2(SO4)] and [Co(L1)(im)2(Cl2)] were found to be active against E.coli.

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DFT, anticancer, antioxidant and molecular docking investigations of some ternary Ni(II) complexes with 2-[(E)-[4-(dimethylamino)phenyl]methyleneamino]phenol

Mohapatra¹,

El-ajaily

Alassbaly

et al. 2020

Chem. Pap.

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Synthesis of some transition metal complexes of novel 1-methylpyrazole-3-aldehyde-4-(2-pyridyl) thiosemicarbazone: Spectroscopic and in vitro biological activity studies

Cited by 4 publications

References 63 publications

One-Dimensional Heterobimetallic Au/Ag Coordination Polymer Showing a Selective, Reversible, and Visible Vapor-Chromic Photoluminescent Response toward Methanol

One-Dimensional Heterobimetallic Au/Ag Coordination Polymer Showing a Selective, Reversible, and Visible Vapor-Chromic Photoluminescent Response toward Methanol

Synthesis, Characterization,Computational Studies and Antimicrobial activity evaluation of Mixed ligand‐Metal complexes of selected thiosemicarbazones

DFT, anticancer, antioxidant and molecular docking investigations of some ternary Ni(II) complexes with 2-[(E)-[4-(dimethylamino)phenyl]methyleneamino]phenol

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