Photostability studies on gemifloxacin and lomefloxacin in bulk powder and dosage forms

Tammam, Marwa Hosny

doi:10.5155/eurjchem.5.1.73-80.884

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…The fluoroquinolone lomefloxacin served as a model compound since this substance was found in various waters in previous studies and also in the nearby River Erft in the course of this study [12,13]. Its irradiation-induced transformation has been described earlier [14,15]. Yet, systematic comparative investigation of near and far ultraviolet (UVA and UVC) irradiation in the presence and absence of hydrogen peroxide and titanium dioxide has not been undertaken.…”

Section: Introductionmentioning

confidence: 99%

Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity

et al. 2020

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Pharmaceuticals in waters represent a worldwide problem of today. Advanced oxidation processes (AOPs) are being researched for elimination of the ecological hazard. Among the substances, the fluoroquinolone antibiotic lomefloxacin was selected for investigation in this study. Lomefloxacin (LOM) was found in the German river Erft. Near and far ultraviolet (UVA, UVC) radiation were used as AOPs and compared for efficiency depending on pH, water matrix, and catalysts. Chemical kinetics description revealed that UVC at pH 8-9 led to the fastest degradation of LOM. The catalysts hydrogen peroxide and titanium dioxide had only limited influence on the degradation rate. Seven novel transformation products were structurally identified by high-resolution higher-order mass spectrometry. Ecotoxicity of the novel and known compounds was assessed by quantitative structure-activity relationship (QSAR) analysis. In addition, irradiation time dependent minimal, and half-maximal inhibitory concentrations (MIC, IC 50 ) of LOM solutions were determined and suggested as ecotoxicological hazard indicators. From MIC and kinetic rate constants, the irradiation time required for compound and activity removal could be predicted.

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Section: Introductionmentioning

confidence: 99%

Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity

et al. 2020

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“…In the literature, different analytical methods have been reported for its determination, including spectrophotometry, [5][6][7] spectrofluorimetry, [8][9][10] high performance thin layer chromatography (HPTLC), [11][12][13][14] high performance layer chromatography (HPLC)-ultraviolet (UV), [15][16][17][18] and liquid chromatography (LC)-mass spectrometry. 19,20 Ultra-performance liquid chromatography (UPLC), introduced in 2004, proved to be more efficient than HPLC in many aspects such as resolution, sensitivity, and consuming much smaller amounts of solvents.…”

Section: Introductionmentioning

confidence: 99%

A Validated Reverse Phase-Ultra-Performance Liquid Chromatography Method for the Determination of Gemifloxacin Mesylate in Bulk and its Pharmaceutical Preparation

Wagdy¹,

Mohamed²,

Amer³

et al. 2019

tjps

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Amaç: Gemifloksasin Mesilat dördüncü jenerasyon fluorokinolon antibakteriyel ajandır. Basit, doğru ve hassas bir ters fazlı (RP)-ultra performanslı sıvı kromatografisi (UPLC) yöntemi, Gemifloksasin Mesilatın, bulk ve farmasötik preparatında kısa sürede analizi için geliştirilmiş ve valide edilmiştir. Gereç ve Yöntemler: Optimum ayırma, Acclaim TM RSLC 120 C18, 2.2 μm (2.1×100 mm) kolonu kullanılarak, 30°C'de, 75:25 (h/h) asetonitril:fosfat tamponu (25 mM) içeren pH 3.0 izokratik hareketli faz ile 0.5±0.03 dk'da elde edildi. Kolon atığı 0.5 mL/dk'lık bir akış hızında fotodiyod detektörü kullanılarak 276 nm'de izlenmiştir. Yöntem Uluslararası Uyumlaştırma Konferansı kılavuzlarına göre valide edildi. Bulgular: Kalibrasyon eğrisinin doğrusallığı 0.5 μg/mL ile 10 μg/mL arasındadır ve regresyon katsayısının karesi (r 2) 0.9991'dir. Gün içi kesinliğin % bağıl standart sapması (RSD) %0.081 ile %1.233 arasında değişirken, günler arası için %0.364 ile %1.018 arasında değişiyordu. Yöntem %93.71 ile %100.29 ve % RSD değeri 1.054 ile 2.722 arasında değişen % geri kazanım ile doğrudur. Saptama limiti ve tayin limiti sırasıyla 0.066 ve 0.2 μg/mL idi. Sonuç: Valide edilmiş yöntem, Gemifloksasin Mesilatın bulk ve dozaj formundan tayininde kısa sürede (1 dakikadan az) tayinin olabileceğini kanıtlamıştır. Bildiğimiz kadarıyla, bu, Gemifloksasin Mesilatın belirlenmesi için ilk RP-UPLC yöntemidir. Anahtar kelimeler: Gemifloksasin Mesilat, ultra performanslı sıvı kromatografisi, metod validasyonu Objectives: Gemifloxacin Mesylate is a fourth generation fluoroquinolone antibacterial agent. A simple, accurate, and precise reversed phase (RP)ultra performance liquid chromatography (UPLC) method was developed and validated for short time analysis of Gemifloxacin Mesylate in its bulk and pharmaceutical preparation. Materials and Methods: The optimum separation was achieved at 0.5±0.03 min using an Acclaim TM RSLC 120 C18 column 2.2 μm (2.1×100 mm) at 30°C by isocratic mobile phase at pH 3.0 composed of acetonitrile:phosphate buffer (25 mM) in a ratio of 75:25 (v/v). The column effluents were monitored at 276 nm using a photodiode array detector at a flow rate of 0.5 mL/min. The method was validated according to International Conference on Harmonization guidelines. Results: The linearity of the calibration curve ranged from 0.5 μg/mL to 10 μg/mL and the square of the regression coefficient (r 2) was 0.9991. The % relative standard deviation (RSD) of inter-day precision ranged from 0.081% to 1.233%, while for intra-day it ranged from 0.364% to 1.018%. The method was accurate with % recovery ranging from 93.71% to 100.29% and % RSD ranging from 1.054 to 2.722. The limit of detection and the limit of quantification were 0.066 and 0.2 μg/mL, respectively. Conclusion: The validated method proved its ability for the assay of Gemifloxacin Mesylate in its bulk and dosage form in a short time (less than 1 min). To the best of our knowledge, this is the first RP-UPLC method for the determination of Gemifloxacin Mesylate.

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“…photodegradation products using two wavelengths 327 and 278 nm (Tammam 2014). • Measurement of the absorbance of the…”

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confidence: 99%

Mini Review on different instrumental approaches applied to some selected drugs for COVID-19 treatment.

Madbouli,

El-adl,

El-Shanawany

2023

Zagazig Journal of Pharmaceutical Sciences

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The quickest methods for battling the new coronavirus pandemic at the beginning of the COVID-19 outbreak were therapeutic treatments based on approved drugs. Although there are now many vaccines available, it will take time for the global vaccination program to take effect. Therefore, in addition to vaccination, repurposing currently available antiviral, antibiotic, and other types of medications has been suggested as a complementary medical strategy for COVID-19 infections. Analytical methods for assessing drug concentrations in biological fluids and pharmaceutical products are necessary due to the drugs' extensive clinical potential as well as their potential side effects. The following article was introduced by presenting a mini-review of the different methods used for the quantitative determination of these drugs in order to encourage and facilitate collecting literature review for other researchers who will have studies related to the presented compounds. The review discussed techniques used for the determination of each drug quantitatively involving spectrophotometric (UV and visible), spectrofluorimetric, electrochemical and chromatographic (TLC and HPLC) methods either in a biological sample or in the pharmaceutical dosage forms. All methods included in the review are validated and constructed according to ICH guidelines.

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Photostability studies on gemifloxacin and lomefloxacin in bulk powder and dosage forms

Cited by 6 publications

References 19 publications

Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity

Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity

A Validated Reverse Phase-Ultra-Performance Liquid Chromatography Method for the Determination of Gemifloxacin Mesylate in Bulk and its Pharmaceutical Preparation

Mini Review on different instrumental approaches applied to some selected drugs for COVID-19 treatment.

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