Stereoselective synthesis of (-) Cephalosporolide D

Fluorescent 7-azaindoleN-linked 1,2,3-triazole: synthesis and study of antimicrobial, molecular docking, ADME and DFT properties

“…, 1-((1-(4-substituted benzyl)-1 H -1,2,3-triazl-4-yl)methyl)-4-halo-1 H -pyrolo[2,3- b ]pyridine. 11 However, Michael P. Clark and his group reported the development of a novel AI-based compound, VX-787 (Fig. 1), which was a first-in-class, orally bioavailable inhibitor of human influenza virus replication.…”

“…10 Surprisingly, 7-AI moiety has not been given proper attention for developing advanced antimicrobial drugs except for one report for synthesizing only some derivatives with 4-Cl or 4-Br substituted 7-AI, e.g., 1-((1-(4-substituted benzyl)-1H-1,2,3-triazl-4-yl)methyl)-4-halo-1H-pyrolo[2,3-b]pyridine. 11 However, Michael P. Clark and his group reported the development of a novel AI-based compound, VX-787 (Fig. 1), which was a first-in-class, orally bioavailable inhibitor of human influenza virus replication.…”

Total Synthesis of Marine Natural Products: Cephalosporolides

“…The chiral pool approach by Harkala et al [26] commenced from glyceraldehyde derivative 32, which on Wittig olefination and double bond reduction gave ester 33. DIBAL-H reduction of the latter to aldehyde and organocatalytic a-aminoxylation [27] followed by in situ NaBH 4 reduction and reductive hydrogenation afforded the chiral diol 34 in good yield (> 97 % de).…”