A microwave-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione derivatives using nanocrystalline MgFe2O4 as catalyst

Ladole, C. A.; Salunkhe, Nilesh; Bhaskar, Ravindra; Aswar, A. S.

doi:10.5155/eurjchem.5.1.122-126.911

Cited by 6 publications

(2 citation statements)

References 30 publications

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“…Biginelli multicomponent reaction was first reported by Biginelli with three components‐aldehyde, β ‐ketoesters, and urea/thiourea in presence of HCl [8] . This reaction was reported by several research groups with different reagents, oxalic acid, p ‐TSA [9] , H 3 BO 3 [10] , thiamine hydrochloride [11] , CeCl 3 [12] , CaCl 2 [13] , polyvinylsulfonic acid [14] , SnCl 2 [15] , Ag 3 PW 12 O 40 [16] , BF 3 .Et 2 O [17] , FeCl 3 [18] , InCl 3 [19] , Mn(OAc) 3 [20] , LiClO 4 [21a] , Yb(OTf) 3 [22a] and other conditions are reported [21b,c, 22b, c,23] . Harsh reaction conditions, long reaction times, expensive reagents, low yields, toxic reaction catalysts, difficult workup procedures, moisture‐free environments, hazardous solvents, strong acidic conditions, and limited substrate scope are shortcomings of some of these reported procedures.…”

Section: Introductionmentioning

confidence: 81%

Efficient Multicomponent Synthesis of Biginelli‐Dihydro‐Pyrimidines and Evaluation of Anti‐Cancer Activity

et al. 2022

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In the presence of imidazole hydrochloride, an efficient one‐pot three‐component synthesis of Biginelli reaction of aromatic aldehydes and aliphatic aldehydes, ethyl acetoacetate, and thiourea/urea was developed with good yields of dihydropyrimidines. High yields (80–95 %), mild reaction conditions, an easy work‐up process, a fast reaction time and simple operations are all significant features of the reaction. A total of 15 dihydropyrimidines were synthesized and out of which 12 compounds were evaluated for their anti‐cancer activity against cancer cell lines viz.A549, HT29, HepG2. Most of the synthesized compounds showed moderate to good anti‐cancer activity (IC50=150>200 μM).

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Section: Introductionmentioning

confidence: 81%

Efficient Multicomponent Synthesis of Biginelli‐Dihydro‐Pyrimidines and Evaluation of Anti‐Cancer Activity

et al. 2022

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“…Yadav and group attempted to synthesize DHPMs using the same strategy and were successful in producing nearly 13 DHPM derivatives with a yield varying from 82 to 90% [ 93 ]. Likewise, NiCl 2 .H 2 O, LaCl 3 .7H 2 O [ 94 ], MgBr 2 [ 95 ], iodine [ 96 ], and MgCl 2 .6H 2 O [ 97 , 98 ] are some other catalysts used for the DHPM synthesis.…”

Section: Advanced Pathwaysmentioning

confidence: 99%

Synthesis of Dihydropyrimidines: Isosteres of Nifedipine and Evaluation of Their Calcium Channel Blocking Efficiency

et al. 2023

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Hypertension and cardiovascular diseases related to it remain the leading medical challenges globally. Several drugs have been synthesized and commercialized to manage hypertension. Some of these drugs have a dihydropyrimidine skeleton structure, act as efficient calcium channel blockers, and affect the calcium ions’ intake in vascular smooth muscle, hence managing hypertension. The synthesis of such moieties is crucial, and documenting their structure–activity relationship, their evolved and advanced synthetic procedures, and future opportunities in this area is currently a priority. Tremendous efforts have been made after the discovery of the Biginelli condensation reaction in the synthesis of dihydropyrimidines. From the specific selection of Biginelli adducts to the variation in the formed intermediates to achieve target compounds containing heterocylic rings, aldehydes, a variety of ketones, halogens, and many other desired functionalities, extensive studies have been carried out. Several substitutions at the C3, C4, and C5 positions of dihydropyrimidines have been explored, aiming to produce feasible derivatives with acceptable yields as well as antihypertensive activity. The current review aims to cover this requirement in detail.

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In3+ doped magnesium ferrite an efficient magnetic catalyst for the synthesis of functionalized quinazolinone and Henry reaction

Naik¹,

Rodrigues

Torney

et al. 2022

J Chem Sci

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A microwave-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione derivatives using nanocrystalline MgFe2O4 as catalyst

Cited by 6 publications

References 30 publications

Efficient Multicomponent Synthesis of Biginelli‐Dihydro‐Pyrimidines and Evaluation of Anti‐Cancer Activity

Efficient Multicomponent Synthesis of Biginelli‐Dihydro‐Pyrimidines and Evaluation of Anti‐Cancer Activity

Synthesis of Dihydropyrimidines: Isosteres of Nifedipine and Evaluation of Their Calcium Channel Blocking Efficiency

In3+ doped magnesium ferrite an efficient magnetic catalyst for the synthesis of functionalized quinazolinone and Henry reaction

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