Polyethylene glycol (PEG-400) as a medium for novel and efficient synthesis of 2-phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives

An ionic liquid catalyzed reusable protocol for one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one under mild conditions

“…2 Moreover, 2,3dihyroquinazolinones are associated with several important biological activities such as, anti-cancer, 3 anti-inflammation, 4 anti-bacterial, 5 anti-virus, 6 anti-tuberculosis, 7 anti-malarial, 8 anti-hypertensive, 9 anti-obesity, anti-psychotic, anti-diabetes, 10 etc. The other reported green procedures for the synthesis of 2,3dihydroquinazolinones have been employed using ionic liquids, 37a-g and organocatalysts such as phosphoric acid, 38 T3P, 39 t BuOK, 40 β-cyclodextrine, 41 polyethylene glycol-400, 42 K 3 PO 4 , 43 p-sulfonic acid (calyx[4]arene) 44 and are known. Transition metals are expensive, unstable and often produce considerable amount of metal wastes.…”

MWCNTs‐ZrO2 as a reusable heterogeneous catalyst for the synthesis of N‐heterocyclic scaffolds under green reaction medium

“…291–293°C. [ 35 ] IR (KBr) ʋ max : 3402, 3,244, 3,158, 1,645, 1,616, 1,508, 1,265 cm −1 . 1 H NMR (600 MHz, DMSO‐d 6 ) δ : 9.02 (s, 1H), 8.98 (s, 1H), 8.07 (s, 1H), 7.61 (d, 1H, J = 6.6 Hz), 7.23 (d, 1H, J = 6.6 Hz), 6.92 (s, 2H), 6.724 (s,), 6.66 (d, 3H, J = 6 Hz), 5.58 (s, 1H) ppm.…”

2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design

“…On the contrary, a simple and environmentally benign procedure, without any catalyst, lengthened the reaction time to hours, although producing similar yield. [184][185][186][187][188][189][190][191][192] The one-pot three-component reaction was also efficiently performed under solvent-free conditions in the presence of heterogeneous catalysts using conventional heating or MWI. The absence of catalyst again afforded 74-97% yield but in longer reaction times (1-6 h).…”