Complex formation equilibria of imipenem with some transition metal ions. Ternary complex formation reactions involving Cu(II) with imipenem and various bio-relevant ligands
Abstract:KEYWORDSImipenem is one of the β-lactam antibiotics (β-lactamase inhibitors), which are reported to be the most important class of drugs that are capable of inhibiting the bacterial enzyme to protect the β-lactam antibiotic from destruction. In view of the biological importance of imipenem as drug, the ligation behavior of imipenem is studied in order to get an idea about its potentiality towards some transition metals in in-vitro systems. The binary complex formation equilibria with the metal ions Cu(II), Ni(… Show more
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