2013
DOI: 10.5155/eurjchem.4.4.360-365.843
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Abstract: KEYWORDSIn this work, the acidic degradation product of sitagliptin phosphate monohydrate (STG) was synthesized, separated and its structure was elucidated. Additionally, two reversed-phase liquid chromatographic (RP-LC) methods have been developed for the determination of STG. The first method comprised the determination of STG in binary mixture with sitagliptin acid degradation product (SDP) in laboratory prepared mixtures, in plasma and in dosage form. This method was based on isocratic elution using a mobi… Show more

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Cited by 6 publications
(15 citation statements)
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“…12 In order to nd out the effect of the differences in stress conditions applied on the drugs and the produced degradates we have performed a comparison between our stress studies and other reported ones (specically reported methods which have elucidated the structures of the produced degradates) as demonstrated in Table 5. Regarding STG and VLG although the applied conditions were different between our proposed method and the reported ones 11,12,32,33 however, in most cases the produced degradates were similar, which proves the validity of the degradation pathways introduced by us in Schemes 1 and 2. As expected the percentage of the produced degradation products was greatly affected by the conditions, the more severe the conditions, the more rapid was the degradation and the higher the percentage of the degradation.…”
Section: Degradation Behaviormentioning
confidence: 51%
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“…12 In order to nd out the effect of the differences in stress conditions applied on the drugs and the produced degradates we have performed a comparison between our stress studies and other reported ones (specically reported methods which have elucidated the structures of the produced degradates) as demonstrated in Table 5. Regarding STG and VLG although the applied conditions were different between our proposed method and the reported ones 11,12,32,33 however, in most cases the produced degradates were similar, which proves the validity of the degradation pathways introduced by us in Schemes 1 and 2. As expected the percentage of the produced degradation products was greatly affected by the conditions, the more severe the conditions, the more rapid was the degradation and the higher the percentage of the degradation.…”
Section: Degradation Behaviormentioning
confidence: 51%
“…16 The results obtained from the statistical analysis 29 showed no signicant difference between the performances of the proposed and reference methods using student's t-test and variance ratio F-test, (Table 3). Accuracy.…”
Section: Methods Validationmentioning
confidence: 94%
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