Synthesis of some new spirocyclic β-lactam and spirocyclic thiazolidin-4-one derivatives

Elkanzi, Nadia A. A.; Yosef, Hisham Abdallah A.; Mohamed, Nesrin Mahmoud Morsy

doi:10.5155/eurjchem.4.3.195-202.777

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…In an analogous approach, spiro-[chloroazetidinethiazolopyrimidine] derivatives were obtained by using the corresponding thiazolopyrimidine imines. 31…”

Section: Methodsmentioning

confidence: 99%

An update on the synthesis and reactivity of spiro-fused β-lactams

Thi¹,

D’hooghe²

2019

Arkivoc

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β-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Spirocyclic βlactams, representing an important β-lactam subclass, have recently attracted considerable interest with respect to new synthetic methodologies and pharmacological applications. The aim of this manuscript is to review the recent progress made in this field, covering publications disseminated between 2011 to 2018 concerning the synthesis and application of spirocyclic β-lactams. In the first part, new approaches to the synthesis of spirocyclic β-lactams, including Staudinger synthesis, cyclization and transformation reactions, will be presented. The reactivity and biological properties of spiro-β-lactams will be described in the second and third part, respectively.

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“…In an analogous approach, spiro-[chloroazetidinethiazolopyrimidine] derivatives were obtained by using the corresponding thiazolopyrimidine imines. 31…”

Section: Methodsmentioning

confidence: 99%

An update on the synthesis and reactivity of spiro-fused β-lactams

Thi¹,

D’hooghe²

2019

Arkivoc

View full text Add to dashboard Cite

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Developments in Synthetic Application of Selenium(IV) Oxide and Organoselenium Compounds as Oxygen Donors and Oxygen-Transfer Agents

2015

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A variety of selenium compounds were proven to be useful reagents and catalysts for organic synthesis over the past several decades. The most interesting aspect, which emerged in recent years, concerns application of hydroperoxide/selenium(IV) oxide and hydroperoxide/organoselenium catalyst systems, as "green reagents" for the oxidation of different organic functional groups. The topic of oxidations catalyzed by organoselenium derivatives has rapidly expanded in the last fifteen years This paper is devoted to the synthetic applications of the oxidation reactions mediated by selenium compounds such as selenium(IV) oxide, areneseleninic acids, their anhydrides, selenides, diselenides, benzisoselenazol-3(2H)-ones and other less often used other organoselenium compounds. All these compounds have been successfully applied for various oxidations useful in practical organic syntheses such as epoxidation, 1,2-dihydroxylation, and α-oxyfunctionalization of alkenes, as well as for ring contraction of cycloalkanones, conversion of halomethyl, hydroxymethyl or active methylene groups into formyl groups, oxidation of carbonyl compounds into carboxylic acids and/or lactones, sulfides into sulfoxides, and secondary amines into nitrones and regeneration of parent carbonyl compounds from their azomethine derivatives. Other reactions such as dehydrogenation and aromatization, active carbon-carbon bond cleavage, oxidative amidation, bromolactonization and oxidation of bromide for subsequent reactions with alkenes are also successfully mediated by selenium (IV) oxide or organoselenium compounds. The oxidation mechanisms of ionic or free radical character depending on the substrate and oxidant are discussed. Coverage of the literature up to early OPEN ACCESSMolecules 2015, 20 10206 2015 is provided. Links have been made to reviews that summarize earlier literature and to the methods of preparation of organoselenium reagents and catalysts.

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Synthesis, reactions, and applications of chalcones: A review

Morsy

Hassan

2022

Eur J Chem

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Considering the essential biological and medicinal properties of chalcones, the synthesis of these compounds has attracted the interest of medicinal and organic chemists. This review aims to describe the different strategies developed so far for the synthesis of chalcones and their applications. After a brief introduction of the chalcones and their biological activities, different synthetic approaches such as chemical and other methods are described and organized on the basis of the catalysts and the other reagents employed in the syntheses. Some of the reactions have been applied successfully to the synthesis of biologically important compounds. Moreover, the biological and pharmacological activities of chalcones have been shown.

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Synthesis of some new spirocyclic β-lactam and spirocyclic thiazolidin-4-one derivatives

Cited by 3 publications

References 46 publications

An update on the synthesis and reactivity of spiro-fused β-lactams

An update on the synthesis and reactivity of spiro-fused β-lactams

Developments in Synthetic Application of Selenium(IV) Oxide and Organoselenium Compounds as Oxygen Donors and Oxygen-Transfer Agents

Synthesis, reactions, and applications of chalcones: A review

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