Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents

Behalo, Mohamed S.; Aly, Ashraf A.; Wasfy, Ashraf Farouk; Rizk, M.M.

doi:10.5155/eurjchem.4.2.92-97.615

Cited by 12 publications

(3 citation statements)

References 21 publications

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“…The tested compounds showed a moderate 66a – b (inhibition zone of 13–15 mm) to high effect 67b (inhibition zone of 20–21 mm) against the tested bacteria, in comparison with tetracycline. It is interesting, that 3-((quinolin-8-yloxy)methyl)-1,2,4triazolo[3,4- b ][1,3,4]thiadiazol-6(5 H )-thione 67b inhibited bacterial growth to a greater extent than its 6-oxo analogue 67a , which showed no antibacterial effect [ 77 ].…”

Section: Antibacterial Activity Of Derivatives Of 124-triazolementioning

confidence: 99%

1,2,4-Triazoles as Important Antibacterial Agents

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2021

Pharmaceuticals

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The global spread of drug resistance in bacteria requires new potent and safe antimicrobial agents. Compounds containing the 1,2,4-triazole ring in their structure are characterised by multidirectional biological activity. A large volume of research on triazole and their derivatives has been carried out, proving significant antibacterial activity of this heterocyclic core. This review is useful for further investigations on this scaffold to harness its optimum antibacterial potential. Moreover, rational design and development of the novel antibacterial agents incorporating 1,2,4-triazole can help in dealing with the escalating problems of microbial resistance.

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Section: Antibacterial Activity Of Derivatives Of 124-triazolementioning

confidence: 99%

1,2,4-Triazoles as Important Antibacterial Agents

Strzelecka

Świątek

2021

Pharmaceuticals

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“…These growing and diverse applications prompted us to continue our ongoing interest on synthesis of these biologically active scaffolds [41][42][43][44][45]. Herein, we describe an efficient synthesis of 1,3,4-thiadiazolyl quinazolinone, triazolyl-, oxooxazolidinyl-and triazinanyl-benzoxazinone scaffolds and evaluation of their anti-microbial activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of in vitro biological activity of new series of quinazolinone and benzoxazinone derivatives

2021

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A convenient synthesis for 1,3,4-thiadiazolyl quinazolinone derivatives is described via facile cyclization of anthranilic acid with succinic anhydride and upon reaction with glycine afforded 3-glycinyl quinazolinone derivative (2), which then treated with thiosemicarbazide and produced 1,3,4-thiadiazolyl quinazolinone derivative (3). Also, the key intermediate isothiocyanatobenzoazinone ( 13) is synthesized and checked for the synthesis of triazolyl-( 14), oxooxazolidinyl-( 15) and triazinanyl-(16a,b) benzoxazinone scaffolds by reaction with phenylhydrazine, glycine and urea and/ or thiourea, respectively.Antimicrobial activity of the synthesized compounds were evaluated against selected bacterial and fungal strains and compared with penicillin and compounds 6, 7b, 10b, 11, 14 and 16b exhibited promising activity as compared to the tested standard. The structures of the products were assigned and confirmed on the basis of their elemental analyses as well as spectral data (IR, MS and 1 H NMR).

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“…In the view of high biological and pharmacological activity of quinazoline derivatives, we reported in our previous work certain substitu quinazoline derivatives [35][36][37][38][39], and we aimed to continue our ongoing interest on synthesis of these scaffolds, and converge our progress in synthesizing some thiadiazolylquinazolinone derivatives. Herein, of antimicrobial activity of some of the synthesized compounds against selected bacteria and fungi strains in comparison with Ampicillin as antibacterial agent and Amphotericin B as antifungal agent exhibited promising activity as es.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of antibacterial and antifungal activity of new series of thiadiazoloquinazolinone derivatives.

2021

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A facile and convenient synthesis of 1,3,4 acid with maleic anhydride, which upon reaction with glycine afforded 3 with thiosemicarbazide and produced 1,3,4 (13) is used as a key compound in synthesizing of triazolyl benzoxazinoneheterocyclesby reaction with phenyl hydrazine, glycine and urea and/ or thiourea, respectively. Evaluation of antimicrobial activity of some of the synthesized compounds against selected bacteria and fungi strains in comparison with Ampicillin as antibacterial agent and Amphotericin B as antifungal agent exhibited promising activity as compared to the references. The structures of the synthesized compounds were confirmed on the basis of their elemental analyses as well as spectral data (IR, MS and 1H NMR).

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Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents

Cited by 12 publications

References 21 publications

1,2,4-Triazoles as Important Antibacterial Agents

1,2,4-Triazoles as Important Antibacterial Agents

Synthesis and evaluation of in vitro biological activity of new series of quinazolinone and benzoxazinone derivatives

Synthesis and evaluation of antibacterial and antifungal activity of new series of thiadiazoloquinazolinone derivatives.

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