Ecofriendly regioselective one-pot synthesis of chromeno[4,3-d][1,2,4]triazolo[4,3-a]pyrimidine derivatives

Synthetic Utility of Pyridinium Bromide: Synthesis and Antimicrobial Activity of Novel 2,4,6‐Trisubstituted Pyridines Having Pyrazole Moiety

“…It was also found that many of these derivatives might block proliferation of various cancer cell lines . In view of the findings mentioned in the preceding texts, and in continuation of our research work aimed at the synthesis of a variety of heterocyclic systems for biological and pharmacological evaluations , we report in the present work an efficient method for the synthesis of a series of new pyridine derivatives pendant to pyrazole moiety.…”

Synthesis and Antimicrobial Activity of Novel Azolopyrimidines and Pyrido‐Triazolo‐Pyrimidinones Incorporating Pyrazole Moiety

“…Furthermore, 1,3‐thiazines are an important group of S,N‐containing heterocycles, which revealed selective antitumoral activity against leukemia cells . The 1,2,4‐triazolopyrimidines have attracted growing interest because of their important pharmacological activities, such as antitumor potency, antimalarial, antimicrobial, anti‐inflammatory, and macrophage activation . In view of all these reports and in continuation of our previous work in synthesis of bioactive pyrazoles , herein, we are interested in synthesizing a new series of azolopyrimidines and pyrido[2,3‐ d ][1,2,4]triazolo[4,3‐ a ]pyrimidinones using pyrazolylchalcones as common precursor and evaluate these compounds for their antimicrobial activities.…”

Synthesis and Antimicrobial Activity of Some New Thiadiazoles, Thioamides, 5-Arylazothiazoles and Pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines

“…In addition, thiazoles can found in drugs developed for the treatment of allergies [13], hypertension [14], inflammation [15], schizophrenia [16], bacterial infections [17], HIV [18], sleep disorders [19] and more recently, for the treatment of pain [20], as fibrinogen receptor antagonists with antithrombotic activity [21], and as new inhibitors of bacterial DNA gyrase B [22]. 1,2,4-Triazolopyrimidines have also attracted growing interest due to their important pharmacological activities, such as antitumor, antimalarial, antimicrobial, anti-inflammatory, antifungal properties, and their potency in macrophage activation [23,24,25,26,27].…”