An efficient synthesis of some new isolated and fused 2-oxo-2H-chromene derivatives as antimicrobial and antitumor agents

Confined Raman Scattering – Easy Access to the Surface Phonons of Specific Crystalline Solids

“…Among these derivatives, chromeno[3,4‐ c ]pyridin‐5‐one12 and benzo[ c ]‐chromen‐6‐ones13 are two classes of special families which are present in a variety of natural products and bioactive molecules with important applications in medicinal chemistry (Figure 1). For example, chromeno[3,4‐ c ]pyridin‐5‐one A can act not only as a selective human dopamine D4 receptor antagonist, but also as a potential antipsychotic agent,12a B shows a wide range of pharmacological properties such as antimicrobial and antitumor activities,12b schumanniophytine C shows central and autonomic nervous system depressant properties and may have potential antiviral activity,12g alternariol D exhibits antifungal and phytotoxic activity, and is reported to inhibit cholinesterase enzymes,13j gilvocarcin E is a kind of bactericidal and antitumor natural product,13k and cannabinol F can be employed clinically as an immunosuppressant. Due to the great importance of the compounds of these families, we wanted to develop new methodologies for the efficient construction of them.…”