Regioselective synthesis of some functionalized 3,4’-bis-(pyrazolyl)ketones and chemoselectivity in their reaction with hydrazine hydrate

Hassaneen, Hamdi M.; Shawali, Ahmad S.

doi:10.5155/eurjchem.4.2.102-109.723

Cited by 10 publications

(4 citation statements)

References 23 publications

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“…Condensation of 3-acetylpyrazole derivative 28 with DMF-DMA in refluxing dioxane yielded the enaminone 41. Treatment of the enaminone 41 with various hydrazonoyl halides 4a-c in refluxing dioxane in the presence of triethylamine furnished the corresponding 3,4 0 -bis-pyrazoles 42-44 (Scheme 17) [80].…”

Section: Severalmentioning

confidence: 99%

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The Chemistry of Acetylpyrazoles and Its Utility in Heterocyclic Synthesis

Abdelhamid

Gomha

2019

Journal of Heterocyclic Chem

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A literature survey revealed that a great deal of interest has been focused on the synthesis of functionalized pyrazole derivatives due to their synthetic and biological potentialities. The pharmacological activities that have been found for some pyrazole derivatives include selective enzyme inhibition, antiviral, estrogen receptor agonist, anti‐inflammatory, anticancer, antiobesity, and antitumor properties. Other activities such as potential inhibitors of HIV‐1, pesticides, fungicides, and antihypertensive agents were reported for other pyrazole derivatives. This review summarizes the synthetic methods and reactions of 3‐acetyl‐pyrazoles, 4‐acetyl‐pyrazoles, and 3,4‐di‐acetyl‐pyrazoles. Most reaction types have been successfully applied and used in the production of biologically active compounds. The aim of this review is to focus mainly on the utility of acetylpyrazole derivatives in the synthesis of heterocyclic compounds during the period 1990–2018.

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Section: Severalmentioning

confidence: 99%

“…Heating 3-acetylpyrazole derivative 28 with hydrazine hydrate in ethanol under reflux gave the pyrazolo [3,4-d]pyridazinone derivative 67a (Scheme 28) [80].…”

Section: Severalmentioning

confidence: 99%

The Chemistry of Acetylpyrazoles and Its Utility in Heterocyclic Synthesis

Abdelhamid

Gomha

2019

Journal of Heterocyclic Chem

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“…The interest in such bis -heterocycles is due to the fact that many of them exhibit more potent biological activities than the monoheterocyclic analogues [7] , [8] , [9] , [10] , [11] , [12] , [13] . In addition, many bis -pyrazole [14] , [15] , [16] , [17] and bis -1,3,4-thiadiazole [18] , [19] , [20] derivatives were reported to exhibit various pharmaceutical, agrochemical and many other applications including antibacterial, fungicidal, tuberculostatic, antiamoebic, and plant growth regulative properties [21] .…”

Section: Introductionmentioning

confidence: 99%