Regiospecific synthesis of some novel N-nucleosides of 4-amino-5-substituted-1,2,4-triazole-3-thiones and their in-vitro antimicrobial activity

Abstract

KEYWORDS 4-Amino-5-substituted-1,2,4-triazole-3-thiones were prepared by following two different reaction routes and comparing the effectiveness of using different reaction conditions. The coupling of aminotriazoles with acetylated α-bromo-D-glucose furnished protected Nnucleosides regiospecifically. The reagents used gave only one regioisomer N-glycosides not the other S-nucleosides. The protected nucleosides upon deacetylation using methanolic ammonia afforded deprotected products. The chemical structures of synthesized compounds were confirmed by FT-IR, 1 H NMR, 13 C NMR, mass spectroscopic and elemental analysis data. All of the synthesized compounds were tested against ten different gram positive and gram negative bacterial strains which exhibited moderate to good antibacterial activity. The deprotected nucleosides portrayed high antibacterial activity than 4-amino-5-substituted-1,2,4-triazole-3-thiones and protected nucleosides against selected bacteria. Spectroscopy N-nucleosides Regiospecificity Antimicrobial activity 1,2,4-Triazole-3-thiones 5-Aryl/hetero aryl substitution

Four Zn/Pb Complexes based on Pyridine containing Mercapto‐triazole Ligand: Syntheses, Structures, and Luminescent Properties

“…All commercially available chemicals and solvents were of reagent grade and used as received without further purification. Ligands 2‐apttH was prepared according to the procedures reported previously . Elemental analyses for C, H, and N were performed with a FLASH EA 1112 elemental analyzer.…”

“…Among the numerous types of organic ligands in complexes, pyridine containing mercapto‐triazole ligands have been discussed previously involving a few amount of research . It deserves further attention because of their strong and versatile coordination behavior for the construction of various MOFs , . On the other hand, aromatic carboxylates have been widely used as auxiliary ligands in MOFs constructed from multidentate N‐heterocyclic molecules .…”