Green methodologies in organic synthesis: Microwave assisted solvent- and catalyst-free synthesis of enaminones and their conversion into 1,3,5-trisubstituted benzenes as well as 3-aroyl-6-substituted pyridines

El‐Apasery, Morsy Ahmed; Al‐Mousawi, Saleh; Elnagdi, Mohamed H.

doi:10.5155/eurjchem.2.2.168-172.228

Cited by 7 publications

(1 citation statement)

References 19 publications

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“…The considerable biological and medicinal activities of nicotinic acid and its derivatives [2][3][4][5] have promoted recent interest in synthesis of new nicotinic acids of potential biological activities. Although condensation reactions of arylhydrazonals with active methylene nitriles were originally reported to afford pyridazin-6-imines [6], more recent studies have demonstrated that arylazonicotinates are also formed in some of these processes [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

An efficient route for the synthesis of some monoazo disperse dyes derived from nicotinic acid derivatives

2013

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KEYWORDSEthyl 2-amino-3-cyano-4-phenylnicotinates (8), could be readily synthesized via reacting ethyl propiolate with benzylidenemalononitrile in the presence of L-proline as a catalyst and subsequent rearrangement of the so formed 2-aminopyran (7), with acetic acid in the presence of ammonium acetate. A series of 2-amino and 2-hydroxyarylazonicotinates monoazo disperse dyes (12a-c), were prepared in a good yields via condensation of arylhydrazonals (11a-c), with active methylene nitriles. The compound 9 was also characterized by single crystal X-ray diffraction studies. Crystal data for compound 9, C15H18O6 (M = 294.29): hexagonal, space group P65 (no. 170), a = 11.3311 (5)

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Section: Introductionmentioning

confidence: 99%

An efficient route for the synthesis of some monoazo disperse dyes derived from nicotinic acid derivatives

2013

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Domino Reactions Based on Combinatorial Bond Transformations in Electron-Deficient Tertiary Enamines

Wan

Gao

2016

The Chemical Record

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Electron-deficient enamines such as enaminones and enaminoesters are moieties showing widespread application in organic synthesis. Among the various available electron-deficient enamines, the N,N-disubstituted amino-functionalized ones (tertiary enamines) represent a class of special enamines with distinct properties and important applications. Based on our longstanding interest in exploring novel synthetic methods using electron-deficient tertiary enamines, we present herein the research advances in organic synthesis via domino reactions making use of the combinatorial C-N, C=C, C-H, and other bond transformations of electron-deficient tertiary enamines.

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Synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones

et al. 2014

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Green methodologies in organic synthesis: Microwave assisted solvent- and catalyst-free synthesis of enaminones and their conversion into 1,3,5-trisubstituted benzenes as well as 3-aroyl-6-substituted pyridines

Cited by 7 publications

References 19 publications

An efficient route for the synthesis of some monoazo disperse dyes derived from nicotinic acid derivatives

An efficient route for the synthesis of some monoazo disperse dyes derived from nicotinic acid derivatives

Domino Reactions Based on Combinatorial Bond Transformations in Electron-Deficient Tertiary Enamines

Synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones

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