Synthesis of substituted pyridine based sulphonamides as an antidiabetic agent

Abstract

This research work describes the synthesis of a new series of heterocyclic compounds, namely sulfonamide derivatives. Sulfonamides are a diverse class of organic compounds having significant and potent biological activities. Diverse synthetic methods have been engaged to build up its various derivatives for different biological functions. In this study, the production of novel pyridine-based heterocyclic compounds having sulfonamide moieties has been elaborated. The obtained sulfonamide-based pyridine scaffold was used to investigate their alpha-amylase inhibition activity. The structures of freshly prepared compounds were described using 1H NMR, 13C NMR, and IR spectroscopic techniques. The molecular docking of sulfonamides performed against porcine pancreatic alpha-amylase using PDB file 1LP was used for generation of grid. All the new synthesized compounds were shown notable anti-diabetic activity.

Nano-Structured Na2CaP2O7: a New and Efficient Catalyst for One-Pot Synthesis of 2-Amino-3-Cyanopyridine Derivatives and Evaluation of Their Antibacterial Activity

“…Indeed, they are key scaffolds in biologically active and naturally occurring substances. Many pharmacological properties of pyridine and its derivatives have been reported including antimicrobial [4], anticancer [5], anti-inflammatory [6], anti-viral [7], anti-diabetic [8], and anti-malarial activities [2]. On the other hand, heterocyclic systems containing the b-enaminonitrile moiety represent a class of intermediates known to be highly reactive and used as precursors for synthesizing newly heterocyclic compounds [9][10][11].…”

Pyridine: the scaffolds with significant clinical diversity

“…Medicinally potent pyridine-based compounds against various biological attributes [73][74][75][76][77][78][79][80]. …”