Novel isoquinoline derivatives from isochromen-1,3-dione

Mahmoud, Mahmoud Refaee; El‐Shahawi, Manal M.; El‐Bordany, Eman A.; El‐Azm, Fatma S. M. Abu

doi:10.5155/eurjchem.1.2.134-139.71

Cited by 11 publications

(10 citation statements)

References 33 publications

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“…In our laboratories, it has been found that when a mixture of isatin and dimethyl homophthalate was treated in absolute methanol in the presence of sodium methoxide, the previously reported 30,31 half ester 1 or six-membered lactone (isocoumarin) 2 have not been isolated, but the lactone 3 was obtained as the sole product (Eq. 1).…”

Section: Resultsmentioning

confidence: 99%

Novel Synthesis of Some Phthalazinone Derivatives

et al. 2011

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Dimethyl homophthalate condensed with isatin to give the unexpected five membered lactone 3 rather than the half ester 1 and the δ-lactone 2. Treatment of compound 3 with excess hydrazine hydrate afforded phthalazinone carbohydrazide 4 which represents a novel method for the synthesis of phthalazinone derivatives. The carbohydrazide 4 upon treatment with carbon disulphide afforded 1,3,4-oxadiazole derivative 5, which reacted with ethylchloroacetate to give the S-alkylated product 6. The structure of compound 3 compared with 2 was discussed using hyperchem professional (7) AM 1 calculations, X-ray single crystal structure and complete spectral data.

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Section: Resultsmentioning

confidence: 99%

Novel Synthesis of Some Phthalazinone Derivatives

et al. 2011

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“…The molarity of amines and reaction time [38] are not the sole factors necessary for cyclization of the anilide derivatives to the corresponding 3-substituted quinazoline derivatives. However, the reaction of 1 with benzidine in nbutanol furnished the cyclized product 10.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of novel quinazolinone and fused quinazolinones

2011

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“…Heterocyclic compounds have been widely utilized in synthesis of pharmacologically active‐compounds . In particular, pyrimidines and fused pyrimidines as key building units of DNA and RNA revealed the fact that their derivatives exhibit diverse pharmacological activities such as anticancer , antiviral , anti‐inflammatory , antioxidant , antibacterial,‐and antifungal‐agents .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Novel Substituted Tetrahydropyrimidine Derivatives and Evaluation of Their Pharmacological and Antimicrobial Activities

Mahmoud

Ghareeb

2018

Journal of Heterocyclic Chem

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Tetrahydropyrimidine derivative 1 was employed as intermediate compound, which in turn was allowed to react with different electrophilic and nucleophilic reagents to synthesize new polyfunctionalized series of substituted pyrimidine‐2‐thione derivatives. Structures of the newly synthesized compounds have been elucidated by spectroscopic data and elemental analyses. The pharmacological and antimicrobial activities of synthesized products have been evaluated as drug candidates.

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Novel isoquinoline derivatives from isochromen-1,3-dione

Cited by 11 publications

References 33 publications

Novel Synthesis of Some Phthalazinone Derivatives

Novel Synthesis of Some Phthalazinone Derivatives

Synthesis of novel quinazolinone and fused quinazolinones

Synthesis of Novel Substituted Tetrahydropyrimidine Derivatives and Evaluation of Their Pharmacological and Antimicrobial Activities

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