Ocorrência de eventos adversos após o uso da vacina adsorvida difteria, tétano e pertussis (acelular) – dTpa –, São Paulo, SP, 2015-2016 *

Abstract

Objective: to describe occurrence of adverse events following immunization (AEFI) with Tdap vaccine during pregnancy. Methods: this was a descriptive study using data from reports by participants in an effectiveness and immunogenicity study conducted in two hospitals in São Paulo, SP, Brazil, from 2015 to 2016. Results: of the 201 mothers included in the study, 48 (23.9%) had at least one AEFI; 60 symptoms related to Tdap use were identified-pain (22.4%), swelling (2.5%), fever (1.5%), somnolence (1.0%), redness (0.5%), vomiting (0.5%), headache (0.5%), local reaction (0.5%), and fatigue (0.5%); no rare, very rare, or extremely rare adverse events were reported; all events were considered to be expected, as they are described in the vaccine package insert; outcome of all events was recovery without sequelae. Conclusion: Tdap vaccine in the form adopted by the National Immunization Program is safe; no unexpected adverse events were identified among vaccinated pregnant women.

Probable Hydrocephalus Decompensation after Immunization with Pentavalent Vaccine: Case Report and Literature Review

“…The DTPa immunizing agent is now used in all individuals in countries such as the United States, precisely because it provides similar protection and may lead to a reduction in serious adverse events. 7,36,48 Patients such as the one herein described, with a condition previously unknown to family members, could not have developed such a complication with the acellular vaccine formulation, and would have avoided emergency surgery due to harmful intracranial hypertension. 4,5,35 Further studies are suggested in patients with ventricular shunts (ventriculoatrial and ventriculoperitoneal) to understand if there is an impact of vaccination with the whole-cell pertussis component, a vaccine currently used in a large scale in Brazil, in the origin of malfunctioning valves.…”

“…These are related to the antigenic components of the pathogen, mainly the pertussis toxin (TP), hemagglutinins, agglutinogens, adenylate cyclase, pertactin and tracheal cytotoxin. 5,[34][35][36] In particular, PT causes ciliary paralysis of the airways due to exacerbated local inflammation. This leads to the accumulation of secretions and/or their inadequate removal, favoring secondary pneumonic processes (which can be severe, especially in the first six months of life).…”

“…These are related to the antigenic components of the pathogen, mainly the pertussis toxin (TP), hemagglutinins, agglutinogens, adenylate cyclase, pertactin and tracheal cytotoxin. 5 34 35 36…”

“…The DTPa immunizing agent is now used in all individuals in countries such as the United States, precisely because it provides similar protection and may lead to a reduction in serious adverse events. 7 36 48…”