O Brasil pode alcançar os novos objetivos globais da Organização Mundia da Saúde para o controle da tuberculose?

Maciel, Ethel Leonor Nóia; Sales, Carolina Maia Martins; Bertolde, Adelmo Inácio; Reis-Santos, Bárbara

doi:10.5123/s1679-49742018000200007

Cited by 16 publications

(14 citation statements)

References 5 publications

(5 reference statements)

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“…These cases have an increased risk of death (Waitt and Squire 2011) and points out the importance of the contact between the individual and health professionals for treatment adherence. Directly observed treatment is an important strategy to favor this contact between health professional and patient, which is especially performed by primary health care teams (Maciel et al, 2018). The association between late death and cure can be explained by situations when the pacient died after the treatment and was not notified again (Rocha et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…These are individual behavioral factors that cause vulnerability, as they make it difficult to adhere to the treatment and, consequently, cure of the patients. Studies indicate the need for actions beyond the health sector in order to reach the social determinants of the disease, and thus obtain better results (Furlan et al, 2012;Maciel et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Early death by tuberculosis as the underlying cause in a state of Southern Brazil: Profile, comorbidities and associated vulnerabilities

Oliveira

Silveira

Beraldi-Magalhães

et al. 2019

International Journal of Infectious Diseases

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To know the profile of adults who died by tuberculosis as the main cause, the time interval between the diagnosis and death, associated comorbidities and vulnerabilities. Method: Observational study of secondary data regarding deaths by tuberculosis that occurred in the State of Paraná, Brazil, from 2008 to 2015. A linkage between the databases of mortality and tuberculosis notification system was conducted for data enrichment. Frequency tables, Exact Fisher test and Z test have identified statistical associations. Results: Linkage points out 12.1% (115/944) of under-reporting in the 944 deaths identified. Early deaths accounted for 74.6% (705/944). The male sex (75.8%) was associated with the early death group. Almost half of the deaths reported in notification system (414/829) had one or more vulnerabilities. Early death were associated with respiratory system diseases and symptoms (p = 0.0001) and mental and behavioral disorders (p = 0.0001). Conclusion: High number of early deaths due TB indicate the need to seek out the respiratory symptomatic and use faster diagnostic methods. Strategies for treatment adherence, adequate monitoring of comorbidities and multisectorial support may prevent early and late death. The presence of vulnerabilities indicates that efforts beyond the health sector are needed in order to eliminate tuberculosis as public health problem.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Early death by tuberculosis as the underlying cause in a state of Southern Brazil: Profile, comorbidities and associated vulnerabilities

Oliveira

Silveira

Beraldi-Magalhães

et al. 2019

International Journal of Infectious Diseases

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“…The steady decline of age-standardized DALY rates due to TB at the national level from 1990 to 2017 corroborates the observed patterns of decreasing trends in TB mortality and incidence in the last decades [ 6 , 22 ]. Substantial progress has been made in reducing TB incidence and mortality in Brazil, with the country meeting the Millennium Development Goals (MDGs) targets for TB control by 2015 [ 31 , 35 , 36 ]. This reduction can be explained by the progress in the access and quality of diagnostic and treatment services provided to patients with TB combined with improvements in the living conditions of the Brazilian population [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

The burden of tuberculosis and attributable risk factors in Brazil, 1990–2017: results from the Global Burden of Disease Study 2017

Martins-Melo

Bezerra

Barbosa

et al. 2020

Popul Health Metrics

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Background Tuberculosis (TB) continues to be an important cause of fatal and non-fatal burden in Brazil. In this study, we present estimates for TB burden in Brazil from 1990 to 2017 using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017). Methods This descriptive study used GBD 2017 findings to report years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) of TB in Brazil by sex, age group, HIV status, and Brazilian states, from 1990 to 2017. We also present the TB burden attributable to independent risk factors such as smoking, alcohol use, and diabetes. Results are reported in absolute number and age-standardized rates (per 100,000 inhabitants) with 95% uncertainty intervals (UIs). Results In 2017, the number of DALYs due to TB (HIV-negative and HIV-positive combined) in Brazil was 284,323 (95% UI: 240,269–349,265). Among HIV-negative individuals, the number of DALYs was 196,366 (95% UI: 189,645–202,394), while 87,957 DALYs (95% UI: 50,624–146,870) were estimated among HIV-positive individuals. Between 1990 and 2017, the absolute number and age-standardized rates of DALYs due to TB at the national level decreased by 47.0% and 68.5%, respectively. In 2017, the sex–age-specific TB burden was highest among males and in children under-1 year and the age groups 45–59 years. The Brazilian states with the highest age-standardized DALY rates in 2017 were Rio de Janeiro, Pernambuco, and Amazonas. Age-standardized DALY rates decreased for all 27 Brazilian states between 1990 and 2017. Alcohol use accounted for 47.5% of national DALYs due to TB among HIV-negative individuals in 2017, smoking for 17.9%, and diabetes for 7.7%. Conclusions GBD 2017 results show that, despite the remarkable progress in reducing the DALY rates during the period, TB remains as an important and preventable cause of health lost to due premature death and disability in Brazil. The findings reinforce the importance of strengthening TB control strategies in Brazil through integrated and multisectoral actions that enable the access to prevention, early diagnosis, and timely treatment, with emphasis on high-risk groups and populations most vulnerable to the disease in the country.

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“… 7 Therefore, during data analysis, line fitting should consider heterogeneity in the treatment’s adoption and use (whether treatment was supervised or not) and Family Health Program coverage by city, as well as socioeconomic variables. 8 …”

Section: To the Editormentioning

confidence: 99%

Reflections upon the article “Evaluation of the impact that the changes in tuberculosis treatment implemented in Brazil in 2009 have had on disease control in the country”

et al. 2018

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O Brasil pode alcançar os novos objetivos globais da Organização Mundia da Saúde para o controle da tuberculose?

Cited by 16 publications

References 5 publications

Early death by tuberculosis as the underlying cause in a state of Southern Brazil: Profile, comorbidities and associated vulnerabilities

Early death by tuberculosis as the underlying cause in a state of Southern Brazil: Profile, comorbidities and associated vulnerabilities

The burden of tuberculosis and attributable risk factors in Brazil, 1990–2017: results from the Global Burden of Disease Study 2017

Reflections upon the article “Evaluation of the impact that the changes in tuberculosis treatment implemented in Brazil in 2009 have had on disease control in the country”

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