Soroprevalência do vírus linfotrópico de células T humanas (HTLV) entre doadores de sangue em hemocentros de Maringá-Paraná e Boa Vista-Roraima

Semeão, Lucas Emmanuel da Silva; Roque, Daniela Ribeiro; Sobrinho, Têdi Francisco; Costa, Cássia Kely Favoretto; Dodorico, Marisa Antonia; Yamaguchi, Mirian Ueda

doi:10.5123/s1679-49742015000300018

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…A frequency of 0.31% HTLV infection was demonstrated. HTLV‐1 is widespread in the northeast and north regions of Brazil, where it is found in the highest prevalence, including blood donors and pregnant women . In this region, the reports showed the prevalence in pregnant women to be around 1.0% and 0.30% in the cities of the states of Bahia and Pará, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…The Brazilian Health Ministry has recommended the investigation of HTLV in the prenatal period, though only some Brazilian cities have HTLV‐1/2 tests included in prenatal care programs . In Paraná state, considered a non‐endemic area, there are few studies specifically carried out in native Indians, blood donors, and pregnant women, mainly in others median size cities . The objective of this study was to estimate the frequency of HTLV‐1/2 infection, and to show the importance of confirmatory molecular methods for HTLV‐1/2, among pregnant women who were followed up in a high‐risk prenatal care unit at the Hospital de Clínicas/Universidade Federal do Paraná Brazil (HC‐UFPR).…”

Section: Introductionmentioning

confidence: 99%

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Confirmatory molecular method for HTLV‐1/2 infection in high‐risk pregnant women

Medeiros

Vidal

Linsingen

et al. 2018

Journal of Medical Virology

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Human T-cell lymphotropic virus types 1/2 (HTLV-1/2) are transmitted through sexual intercourse, transfusion of blood components, and vertical transmission, predominantly through breastfeeding. Six hundred forty-three pregnant women from a high-risk prenatal care unit at a general hospital were tested by serological tests using chemiluminescence (CMIA) for screening, followed by a molecular confirmatory test. Four patients (0.6%) tested positive for HTLV-1/2 by CMIA, two samples (0.3%) for each patient were confirmed as having HTLV-1 or HTLV-2 by PCR. The results show the importance of inclusion of HTLV-1/2 screening for pregnant women in high-risk prenatal care and the need for a molecular biological method to confirm HTLV-1/2 infection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Confirmatory molecular method for HTLV‐1/2 infection in high‐risk pregnant women

Medeiros

Vidal

Linsingen

et al. 2018

Journal of Medical Virology

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“…The Human T cell Lymphotropic Virus (HTLV) is a retrovirus of the genus Deltaretrovirus, which belongs to the family Retroviridae [1] and has tropism for T lymphocytes, with four types, HTLV-1, HTLV-2, HTLV-3, and HTLV-4. The HTLV-1 is the most relevant pathogen, being associated with severe diseases, such as Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (HAM/TSP), while the HTLV-2 type is also epidemiologically important, but is not associated systematically with other pathologies [2,3,4].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and Molecular Profile of Blood Donors Infected With HTLV-1/2 in the State of Pará, Northern Brazil

Maneschy

Barile

Castro

et al. 2021

Preprint

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Background: The Human T Cell Lymphotropic Virus (HTLV) is a retrovirus of the genus Deltaretrovirus, which belongs to the family Retroviridae, and has tropism for T lymphocytes. This virus has four types, of which the most important in terms of pathogenesis and epidemiology are HTLV-1 and HTLV -2. It is estimated that between five and 10 million individuals are infected with HTLV-1, worldwide, of which, approximately 2.5 million live in Brazil. Studies in the state of Pará indicate that it has the third highest prevalence of HTLV infections of any Brazilian state. The virus can betransmitted through sexual, vertical, and parenteral route. The present study describes the epidemiological, serological, and molecular profile of blood donors from the state of Pará, that were classified as unfit due to infection by HTLV-1 and 2. Results: A total of 632 samples were analyzed. The HTLV proviral DNA was detected primarily in females (69.1%), with a mean age of 40 years, with the highest frequencies of detection being recorded in single individuals (66.2%), first-time donors (74.3%), and individuals that had graduated high school (44.1%). The molecular confirmation of HTLV showed that threequarters (78%) of the serologically reactive individuals were negative for either types I or II, so the epidemiological profile of these individuals was significantly different from their detectable profile. Conclusions: The HTLV is a neglected etiological agent in Brazil, and although there have been many advances since its discovery, infection patterns are still relatively poorly understood by both healthcare professionals and the general population. There is thus a clear need for further research in the area of regional hemotherapy and hematology services, in order to contribute to the definition of regional infection profiles, that will be fundamental to the development of effective prophylactic practises for the prevention of the infection and the dissemination of knowledge on the dangers of HTLV in the community.

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“…Existem 4 subtipos conhecidos do HTLV, sendo os mais importantes o HTLV-1 e 2, quanto a patogenia e epidemiologia. É transmitido através de relações sexuais, onde em pessoas do sexo feminino, a transmissão é quatro vezes maior, em comparação a transmissão da mulher para o homem pela via sexual, sanguínea e vertical 2,4,5 .…”

Section: Introductionunclassified

“…Outros meios de transmissão são pela utilização de produtos infectados com sangue do indivíduo com a doença, e transmissão vertical, a passada de mãe para filho, contudo aproximadamente 90% dos contaminados permanecerão assintomáticos, mantendo assim uma rede de transmissão silenciosa, contudo com baixa morbidade 4,5 .…”

Section: Introductionunclassified

Capacidade funcional em indivíduos com paraparesia espástica tropical/mielopatia associada ao HTLV-1

Corrêa

Rocha²,

Almeida³

et al. 2018

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Este estudo teve como objetivo avaliar a capacidade funcional de indivíduos com paraparesia espástica tropical/mielopatia associada ao vírus linfotrófico humano de células T do Tipo 1 (PET/MAH). A pesquisa incluiu 12 indivíduos diagnosticados com HTLV-1 de ambos os sexos, em acompanhamento no Laboratório de Estudos em Reabilitação Funcional (LAERF) da Universidade Federal do Pará (UFPA), através da aplicação do Health Assessment Questionnaire (HAQ). Este é um estudo quantitativo realizado em 2016. Dos participantes 58,3% eram do sexo feminino e 41,6% do sexo masculino. Apresentaram incapacidade moderada à grave 50% dos pesquisados, devido à dificuldade de deambular e alterações na postura e equilíbrio, necessitando assim de auxílio de terceiros e muletas e cadeiras de rodas. A problemática do viver com o HTLV-1 é abrangente e complexa, interferindo no cotidiano, estando relacionada a sintomatologia da doença e requerendo cuidados paliativos na capacidade funcional do dia-a-dia, principalmente, na funcionalidade que envolve os membros inferiores, as transferências de posturas e o equilíbrio.

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Soroprevalência do vírus linfotrópico de células T humanas (HTLV) entre doadores de sangue em hemocentros de Maringá-Paraná e Boa Vista-Roraima

Cited by 6 publications

References 20 publications

Confirmatory molecular method for HTLV‐1/2 infection in high‐risk pregnant women

Confirmatory molecular method for HTLV‐1/2 infection in high‐risk pregnant women

Epidemiological and Molecular Profile of Blood Donors Infected With HTLV-1/2 in the State of Pará, Northern Brazil

Capacidade funcional em indivíduos com paraparesia espástica tropical/mielopatia associada ao HTLV-1

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