Avaliação do processo de dispensação de medicamentos aos portadores de hepatite C crônica em farmácias de componentes especializados da Secretaria de Estado da Saúde de São Paulo, em 2010

Venâncio, Sônia Isoyama; Bersusa, Ana Aparecida Sanches; Martins, Patrícia Nieri; Figueiredo, Gerusa Maria; Awakamatsu, Alda; Alves, Venâncio Avancini Ferreira

doi:10.5123/s1679-49742014000400012

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Approximately 3% of the world's population (170 million people) is afflicted with chronic HCV infections, which pose a risk for the development of cirrhosis, hepatocellular carcinoma, and liver failure [ 29 – 31 ].…”

Section: Discussionmentioning

confidence: 99%

Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus

Padilla

Rodrigues

Bastos

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Extracts from termite-associated bacteria were evaluated for in vitro antiviral activity against bovine viral diarrhea virus (BVDV). Two bacterial strains were identified as active, with percentages of inhibition (IP) equal to 98%. Both strains were subjected to functional analysis via the addition of virus and extract at different time points in cell culture; the results showed that they were effective as posttreatments. Moreover, we performed MTT colorimetric assays to identify the CC50, IC50, and SI values of these strains, and strain CDPA27 was considered the most promising. In parallel, the isolates were identified as Streptomyces through 16S rRNA gene sequencing analysis. Specifically, CDPA27 was identified as S. chartreusis. The CDPA27 extract was fractionated on a C18-E SPE cartridge, and the fractions were reevaluated. A 100% methanol fraction was identified to contain the compound(s) responsible for antiviral activity, which had an SI of 262.41. GC-MS analysis showed that this activity was likely associated with the compound(s) that had a peak retention time of 5 min. Taken together, the results of the present study provide new information for antiviral research using natural sources, demonstrate the antiviral potential of Streptomyces chartreusis compounds isolated from termite mounds against BVDV, and lay the foundation for further studies on the treatment of HCV infection.

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Section: Discussionmentioning

confidence: 99%

Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus

Padilla

Rodrigues

Bastos

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Immunohistochemical Assessment of Lymphatic Vessels in Human Livers With Chronic Hepatitis C - Relation to Histological Variables

Assato

Pasinato

Cirqueira

et al. 2022

Arq. Gastroenterol.

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Background Viral hepatitis C is a significant public health challenge. The disease may remain clinically silent in both acute and chronic forms, and chronic infections may progress to advanced disease such as cirrhosis and hepatocellular carcinoma, requiring costly treatment, compromising the patient’s quality of life and even leading to death. For this reason, it is one of the most frequent indications for liver transplantation. Although treatment with direct-acting antivirals represents remarkable progress, many patients are still infected and even those who cleared the viral infection must be followed due to their previous hepatic lesions, especially regarding the disturbances of lobular architecture and the sanguineal and lymphatic vessels. Objective To assess immunohistochemical aspects of lymphatic sprouts and mature lymphatic vascularity with histological variables of liver injury attributable to hepatitis C virus (HCV) and fatty disease. Methods The present study included 72 liver biopsies of cases with chronic hepatitis C. Morphologic changes reflecting “staging” and “activity” were analyzed. Immunohistochemical reactions were performed with monoclonal antibody D2-40 anti-podoplanin. Major histological variables were also semiquantified so as to enable the search for possible associations among histological and Immunohistochemical criteria, as well as with genotypes 1 and 3 of HCV. Results Histological findings showed that the different degrees of strutural changes were well represented in this casuistic. Intralobular/parenchymal necro-inflammatory activity was predominantly mild to moderate. Most cases did not show major evidences of fatty disease, which was found significantly higher in cases infected with HCV genotype 3. The amount of portal lymphatic sprouts increased along with the progression of structural changes, maximal at cirrhosis. Portal lymphatic sprouts as well as portal mature lymphatic vessels also showed an increase parallel to the increase in the degree of portal/septal inflammatory infiltrate. In the present study, no significant association was found between the proportion of portal lymphatic sprouts or portal mature lymphatic vessels and the degree of periportal/periseptal activity. No significant relations were detected between lymphatic sprouts/mature vessels and periportal or parenchymal inflammatory activity, nor with infections due to HCV genotype 1 or 3. Conclusion Visualization and semiquantitation of sprouts and mature lymphatic vessels were clearly yielded by Immunohistochemical staining with monoclonal antibody D2-40. The amount of lymphatics was increased along fibrogenic process, significantly related to progression of liver disease and maximal at cirrhosis. No significant relations were detected with necro-inflammatory activity at interface or in the parenchyma.

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Perfil epidemiológico de pacientes com Hepatite C no componente especializado da assistência farmacêutica do Piauí

Carvalho

Ferreira

Leitão

2020

RSD

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This study aimed to characterize the epidemiological profile of patients with hepatitis C assisted by the specialized component of Pharmaceutical Care in Teresina, Piauí, in 2018. This is a cross-sectional, observational study with a qualitative and quantitative approach, developed in Brazil. Specialized Component of Pharmaceutical Assistance in Teresina, Piauí, in 2019. The data collected refer to a sample of 100 processes. After the analysis, the information was recorded in the forms, and later in a spreadsheet, where the analysis procedure was performed through statistics. In this group, the average age was 57.9 years, with a higher prevalence of the age group. from 50 to 68 years old (63%), male (57%), mixed race (57%) and individuals with type 1 genotype (40.40%). The most commonly used regimen is Daclastavir + Sofosbuvir (40%) and the most common treatment line was 12 weeks (83%). The vast majority (93%) do not have any coinfection, but the most frequent coinfection in the sample is caused by the Human Immunodeficiency Virus (HIV). Most of the results found are in accordance with the literature. There are few studies about Hepatitis C in Brazil, considering this situation, it is considered important to know the prevalence of Hepatitis C, to raise awareness of the transmission pathways, as well as its symptoms, since it is a silent infection and can progress to chronicity, and on the effectiveness of the existing treatment, which is offered by the Unified Health System.

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Avaliação do processo de dispensação de medicamentos aos portadores de hepatite C crônica em farmácias de componentes especializados da Secretaria de Estado da Saúde de São Paulo, em 2010

Cited by 3 publications

References 17 publications

Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus

Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus

Immunohistochemical Assessment of Lymphatic Vessels in Human Livers With Chronic Hepatitis C - Relation to Histological Variables

Perfil epidemiológico de pacientes com Hepatite C no componente especializado da assistência farmacêutica do Piauí

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