Introduction: Studies comparing periodization models in sequences that begin with small muscle group and progressed toward large muscle group in untrained subjects in resistance training are scarce. Objective: The purpose of this study was to compare the effects of ondulatory periodization and linear periodization models on maximum strength and muscular hypertrophy in a muscle group increasing exercise sequence. Methods: Twenty-nine men with no experience in RT were randomly assigned into three groups: ondulatory periodization (OP, n = 10), linear periodization (LP, n = 13), and control group (CG, n = 9). The individuals performed 1RM tests in four exercises: biceps curl (BC), triceps extension (TE), lat pull down (LPD) and bench press (BP) and evaluations of maximum voluntary isometric contraction (MVIC), muscle thickness of elbow flexors (EF) and elbow extensors (EE) before and after the 12 weeks of training were carried out. The OP group varied in volume and intensity on a daily basis, while LP group varied every four weeks. The CG did not perform ST. A two-way ANOVA with repeated measures and the effect size (ES) were used to analyze muscle thickness, 1RM load improvement in each of the four exercises and the MVIC between groups. Results: The major findings of this study were: 1) OP showed major ES for 1RM of BC and TE and for muscle thickness of EF and EE when compared with LP.3) The ES data did not show significant differences for BP and LPD which finished the training session. Conclusions: We conclude that both periodization models were efficient at improving strength gains and muscular growth. However, ES data show that OP promotes major gains in strength for exercises that are positioned at the beginning of the session and hypertrophy.