Childhood trauma is associated with age at onset of symptoms, functioning, and cognition in patients with schizophrenia

De-Nardin, Emmanuely Macedo Santana; Muratori, Camilla Alves; Ribeiro, Isabela Serra; Huguete, Rodrigo Barreto; Salgado, João Vinícius

doi:10.47626/2237-6089-2019-0081

Cited by 3 publications

(1 citation statement)

References 42 publications

(47 reference statements)

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“…Individuals with a history of childhood trauma are at high risk for psychosis (Kraan et al, 2015). Childhood trauma affects the onset (De-Nardin, Muratori, Ribeiro, Huguete, & Salgado, 2022) and severity of positive and dysthymia symptoms (Ruby, Rothman, Corcoran, Goetz, & Malaspina, 2017) as well as cognitive functions (Dauvermann & Donohoe, 2019) and treatment outcomes (Kilian et al, 2020) in schizophrenia. For instance, patients with a history of childhood trauma demonstrated delayed symptom remission (Aas et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Subcortical structures associated with childhood trauma and perceived stress in schizophrenia

et al. 2022

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Background Childhood trauma influences the clinical features of schizophrenia. In this study, we examined how childhood trauma and perceived stress are associated with clinical manifestations and subcortical gray matter volumes (GMVs) in patients with schizophrenia. Methods We recruited 127 patients with schizophrenia and 83 healthy controls for assessment of early childhood trauma, perceived stress, and clinical symptoms. With structural brain imaging, we identified the GMVs of subcortical structures and examined the relationships between childhood trauma, perceived stress, clinical symptoms, and subcortical GMVs. Results Compared to controls, patients with schizophrenia showed higher levels of childhood trauma and perceived stress. Patients with schizophrenia showed significantly smaller amygdala and hippocampus GMVs as well as total cortical GMVs than age-matched controls. Childhood trauma score was significantly correlated with the severity of clinical symptoms, depression, perceived stress, and amygdala GMVs. Perceived stress was significantly correlated with clinical symptoms, depression, and hippocampus and amygdala GMVs. Further, the association between childhood trauma (emotional neglect) and stress coping ability was mediated by right amygdala GMV in patients with schizophrenia. Conclusions Patients with schizophrenia had more exposure to early-life trauma and poorer stress coping. Both childhood trauma and perceived stress were associated with smaller amygdala volumes. The relationship between early-life trauma and perceived stress was mediated by right amygdala GMV in patients with schizophrenia. These findings together suggest the long-term effects of childhood trauma on perceived stress and the subcortical volumetric correlates of the effects in schizophrenia.

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Section: Introductionmentioning

confidence: 99%

Subcortical structures associated with childhood trauma and perceived stress in schizophrenia

et al. 2022

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Rumination mediates the relationship between childhood trauma and depressive symptoms in schizophrenia patients

Fang

Wen

et al. 2022

Eur Arch Psychiatry Clin Neurosci

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Association of childhood trauma with cognitive domains in adult patients with mental disorders and in non-clinical populations: a systematic review

2023

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Although the association between cognitive performances and the onset of psychiatric disorders has been widely investigated, limited research on the role of childhood trauma or early life stress (CT/ELS), and whether this role differs between clinical and non-clinical cohorts is available. This systematic review aims at filling this gap, testing whether the occurrence of CT/ELS and its subtypes are associated with cognitive domains (general cognitive ability, executive functions, working memory, attention, processing speed, verbal/visual memory) in patients with psychiatric disorders and in non-clinical populations. This study followed the PRISMA 2020 guidelines and the Newcastle-Ottawa scale for quality assessment. The search was performed until May 2022. Seventy-four studies were classified as eligible. The graphical representations of the results reported an association between exposure to CT/ELS and worse general cognitive ability, verbal/visual memory, processing speed and attention in patients affected by anxiety, mood and psychotic disorders, and that specific CT/ELS subtypes (physical neglect, physical/sexual abuse) can differentially influence specific cognitive abilities (executive functions, attention, working memory, verbal/visual memory). In non-clinical cohorts we found associations between CT/ELS exposure and impairments in executive functions, processing speed and working memory, while physical neglect was related to general cognitive ability and working memory. Concerning the emotional abuse/neglect subtypes in both populations, the results indicated their involvement in cognitive functioning; however, the few studies conducted are not enough to reach definitive conclusions. These findings suggest an association of CT/ELS with specific cognitive deficits and psychopathology.

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Childhood trauma is associated with age at onset of symptoms, functioning, and cognition in patients with schizophrenia

Cited by 3 publications

References 42 publications

Subcortical structures associated with childhood trauma and perceived stress in schizophrenia

Subcortical structures associated with childhood trauma and perceived stress in schizophrenia

Rumination mediates the relationship between childhood trauma and depressive symptoms in schizophrenia patients

Association of childhood trauma with cognitive domains in adult patients with mental disorders and in non-clinical populations: a systematic review

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