Comparison of opioid use disorder patients with and without problematic internet use in terms of impulsivity and attention deficit hyperactivity disorder

Bal, Nese Burcu; Örnek, Bahar Yesil

doi:10.47626/1516-4446-2024-3585

Brazilian Journal of Psychiatry

2024

DOI: 10.47626/1516-4446-2024-3585

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Comparison of opioid use disorder patients with and without problematic internet use in terms of impulsivity and attention deficit hyperactivity disorder

Nese Burcu Bal,

Bahar Yesil Örnek

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Exploring the genetic and socioeconomic interplay between ADHD and anxiety disorders using Mendelian randomization

Deng,

Ren,

et al. 2024

Front. Psychiatry

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BackgroundADHD and anxiety disorders often co-occur, sharing symptoms and dysfunctions, yet the underlying mechanisms remain elusive.MethodsTo explore the shared and distinct genetic variations between ADHD and anxiety disorders, we applied Mendelian randomization (MR) analysis to ADHD, anxiety disorders, and three socioeconomic factors: income, educational attainment (EA), and intelligence. MR analysis utilized genome-wide association study summary datasets (anxiety disorder: 7,016 cases and 14,745 controls; ADHD: 38,691 cases and 275,986 controls; EA: 766,345 participants; intelligence: 146,808 participants; household income: 392,422 participants), with inverse-variance weighting as the primary method.ResultsOur MR analysis revealed no discernible genetic-level causal effect between ADHD and anxiety disorders (p > 0.77). Additionally, the independent variables for ADHD (25 SNPs) and anxiety disorders (18 SNPs) did not overlap, highlighting the genetic distinction between the two conditions. Higher income (p < 0.002) and EA (p < 0.005) were found to serve as protective factors for both ADHD and anxiety disorders. Genetic predisposition to higher income (86 SNPs) and EA (457 SNPs) were identified as a potential common protective factors for both conditions. Lastly, genetic predisposition to higher intelligence was found to potentially guard against ADHD (p < 0.001) but not against anxiety disorders (p > 0.55).ConclusionOur findings indicate that the shared symptoms observed between ADHD and anxiety disorders are more likely influenced by genetic predispositions related to socioeconomic factors rather than by the genetic predispositions specific to the disorders themselves.

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Exploring the genetic and socioeconomic interplay between ADHD and anxiety disorders using Mendelian randomization

Deng,

Ren,

et al. 2024

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

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Comparison of opioid use disorder patients with and without problematic internet use in terms of impulsivity and attention deficit hyperactivity disorder

Cited by 1 publication

References 0 publications

Exploring the genetic and socioeconomic interplay between ADHD and anxiety disorders using Mendelian randomization

Exploring the genetic and socioeconomic interplay between ADHD and anxiety disorders using Mendelian randomization

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