Multidisciplinary contributions towards an evolutive interpretation of bipolar disorders: Could it be the pathological drift of a potentially adaptive condition?

The impact of MDQ positivity on quality of life impairment: Does it support the hypothesis of “Dysregulation of Mood, Energy, and Social Rhythms Syndrome” (DYMERS)?

“…31 The absence of a linear relationship cannot exclude an association that could exist but be mild if this genetic factor interacts with concomitant co-factors. In fact, some elements, such as the attitude of hyperactivity, typical of bipolar disorder, can be found in people who do not suffer from this disorder in specific conditions of conflict or social danger, 32 and a high frequency of a genetic variant (the allele RS1006737 of the CACNA1C gene considered a risk factor for bipolar disorder) was found in elderly people with hyperactivity/novelty-seeking traits but who are perfectly socially integrated and without any psychiatric diagnosis. 33–35…”

“…31 The absence of a linear relationship cannot exclude an association that could exist but be mild if this genetic factor interacts with concomitant co-factors. In fact, some elements, such as the attitude of hyperactivity, typical of bipolar disorder, can be found in people who do not suffer from this disorder in specific conditions of conflict or social danger, 32 and a high frequency of a genetic variant (the allele RS1006737 of the CACNA1C gene considered a risk factor for bipolar disorder) was found in elderly people with hyperactivity/novelty-seeking traits but who are perfectly socially integrated and without any psychiatric diagnosis. [33][34][35] In this framework, even admitting that the presence of the "at-risk variant" may be found also in the not-at-risk subgroup, this cannot cancel a possible BD-genetic variant association relationship but certainly cannot justify a 18 2.9 ± 7.4 0.004 (1, 208) 0.948 Fibromyalgia 29 4.77 ± 5.76 0.975 (1,78) 0.327 Wilson disease 19 3.2 ± 7.9 0.027 (1,23) 0.072 Celiac disease 17 3.4 ± 5.4 0.119 (1,67) 0.732 Carotidal atherosclerosis 20 3.4 ± 8.2 0.052 (1,53) 0.821 MDQ positivity 2.73 ± 2.44 Pivot linear correlation.…”