Social cognition across bipolar disorder and behavioral variant frontotemporal dementia: an exploratory study

Barbosa, Izabela Guimarães; Leite, Flávia da Mata Chiácchio; Bertoux, Maxime; Guimarães, Henrique Cerqueira; Mariano, Luciano Inácio; Gambogi, Leandro Boson; Teixeira, Antônio Lúcio; Caramelli, Paulo; Souza, Leonardo Cruz de

doi:10.47626/1516-4446-2022-2935

Cited by 1 publication

(10 citation statements)

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“…The remaining 91 studies were rated low quality according to the QUADAS-2 appraisal. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]52,[54][55][56][57][58][59][60][61][62][63][64][102][103][104][105][106]…”

Section: Results From Low-quality Studiesmentioning

confidence: 99%

“…The titles and abstracts were reviewed, with 633 articles identified that potentially met inclusion criteria. These articles were then reviewed in full, yielding 96 articles that met eligibility criteria 15–110 (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Thirty‐nine studies (Table 1) described the disease severity of bvFTD and the remaining studies did not. Five studies described the disease severity of the comparator cohort, but not in the cohort with bvFTD 21,32,50,64,70 . When mentioned, studies described bvFTD disease severity as “mild” ( n = 24) or “mild to moderate” ( n = 15).…”

Section: Resultsmentioning

confidence: 99%

“…The remaining 91 studies were rated low quality according to the QUADAS‐2 appraisal 15–34,36–50,52,54–64,66–100,102–110,127–129 . These studies assessed (a) neuropsychological tests, (b) cognitive batteries, (c) behavioral tools, and (d) other clinical tools.…”

Section: Resultsmentioning

confidence: 99%

“…43 Social cognition (Table 3). Seventeen studies of low-quality according to the QUADAS-2 appraisal 17,19,29,32,33,37,40,[46][47][48][49][50]52,[54][55][56][57] used social cognition tests to differentiate bvFTD from healthy controls and other conditions, including AD, PSP, CBS, PPA, MDD, BDI, presymptomatic FTD genetic carriers and mixed neurological and/ or psychiatric cohorts. Social cognition tests were consistently reported as good to excellent at differentiating bvFTD from healthy controls, presymptomatic FTD genetic carriers, AD, and MDD.…”

Section: Neuropsychological Testsmentioning

confidence: 99%

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A systematic review of cognitive and behavioral tools to differentiate behavioral variant frontotemporal dementia from other conditions

Flavell,

Nestor

2024

PCN Reports

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The behavioral variant of frontotemporal dementia (bvFTD) is thought to be the commonest clinical presentation of frontotemporal lobar degeneration and is predominantly characterized by changes in behavior. In patients lacking unequivocal biomarker evidence of frontotemporal neurodegeneration, the clinical diagnosis of bvFTD is often unstable. In response, we conducted a systematic review and critical appraisal of cognitive and behavioral tools that have sought to differentiate bvFTD from other conditions. A systematic literature review of PubMed, Scopus, and Web of Science was conducted on December 31, 2023 for cognitive and behavioral tools that differentiated bvFTD from other cohorts. Ninety‐six studies were included. The quality appraisal of almost all studies was low and introduced a high risk of bias. The few studies that were of high quality had a prospective study design and recruited patients suspected (but not yet confirmed) to have bvFTD. These studies reported that behavioral tools (e.g., the Frontal Behavioral Inventory) and social cognition tests (e.g., the Ekman's Faces Test) had good test performance in differentiating bvFTD from a broad range of psychiatric and neurological conditions. Importantly, the review highlighted the extreme paucity of studies that have evaluated methods where, in Bayesian terms, there is genuine clinical uncertainty regarding a diagnosis of bvFTD. Most studies used healthy controls or typical Alzheimer's disease as comparators—groups that often have negligible pretest probability of bvFTD. In response, we propose a study design checklist for studies seeking to develop diagnostic algorithms in bvFTD research.

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