Chronic stress and complement system in depression

Pillai, Anilkumar

doi:10.47626/1516-4446-2022-2463

Cited by 3 publications

(3 citation statements)

References 8 publications

(15 reference statements)

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“…The complement system encompasses more than 40 proteins that are soluble or bound to membranes, and can be found in serum, tissue fluids, and cell surfaces. In its inactive state, it is present in bodily fluids or the central nervous system (CNS), and becomes activated through a cascade of enzymatic reactions, resulting in diverse biological outcomes [ 6 ]. Initially, the liver is believed to be the primary origin of complement proteins.…”

Section: Main Bodymentioning

confidence: 99%

“…Suppression of the C3a signaling has been found to alleviate the depressive behaviors induced by chronic stress in mice[ 20 ]. Prior investigations have suggested that the complement system within neuroglial cells may serve as a crucial connection in the comorbidity mechanism of chronic pain and depression [ 6 , 26 ]. Consequently, this article primarily investigates the molecular mechanisms of the complement system as a prospective therapeutic target for depression and chronic pain.…”

Section: Main Bodymentioning

confidence: 99%

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The complement system: a potential target for the comorbidity of chronic pain and depression

Tang,

Hu,

Zou

et al. 2024

Korean J Pain

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The mechanisms of the chronic pain and depression comorbidity have gained significant attention in recent years. The complement system, widely involved in central nervous system diseases and mediating non-specific immune mechanisms in the body, remains incompletely understood in its involvement in the comorbidity mechanisms of chronic pain and depression. This review aims to consolidate the findings from recent studies on the complement system in chronic pain and depression, proposing that it may serve as a promising shared therapeutic target for both conditions. Complement proteins C1q, C3, C5, as well as their cleavage products C3a and C5a, along with the associated receptors C3aR, CR3, and C5aR, are believed to have significant implications in the comorbid mechanism. The primary potential mechanisms encompass the involvement of the complement cascade C1q/C3-CR3 in the activation of microglia and synaptic pruning in the amygdala and hippocampus, the role of complement cascade C3/C3a-C3aR in the interaction between astrocytes and microglia, leading to synaptic pruning, and the C3a-C3aR axis and C5a-C5aR axis to trigger inflammation within the central nervous system. We focus on studies on the role of the complement system in the comorbid mechanisms of chronic pain and depression.

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Section: Main Bodymentioning

confidence: 99%

Section: Main Bodymentioning

confidence: 99%

The complement system: a potential target for the comorbidity of chronic pain and depression

Tang,

Hu,

Zou

et al. 2024

Korean J Pain

View full text Add to dashboard Cite

show abstract

“…Depression in ESRD patients may be linked to inflammation. Evidence suggests that chronic stress results in increased inflammatory responses and that higher levels of proinflammatory markers have been discovered in the brain tissue of depressed individuals, indicating that inflammation may influence depressive symptoms [92]. The complement system may be a key mediator of inflammatory changes affecting psychiatric disorders.…”

Section: Influence Of Dialysis Membrane Hemocompatibility and Clinica...mentioning

confidence: 99%

Quality of Life of Dialysis Patients: Exploring the Influence of Membrane Hemocompatibility and Dialysis Practices on Psychosocial and Physical Symptoms

Doan,

Shoker,

Abdelrasoul

2024

J. Compos. Sci.

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Hemodialysis (HD) is a life-sustaining membrane-based therapy that is essential for managing kidney failure. However, it can have significant physical and psychological effects on patients due to chronic or acute consequences related to membrane bioincompatibility. End-stage renal disease (ESRD) patients on hemodialysis have a high incidence of psychiatric illness, particularly depression and anxiety disorders, and poor quality of life has been observed. Dialysis can also lead to physical symptoms of its own, such as fatigue, loss of appetite, anemia, low blood pressure, and fluid overload, in addition to the symptoms associated with kidney failure. Therefore, this critical review aims to comprehensively understand the impact of dialysis membrane bioincompatibility and the use of varying molecular weight cut-off membranes on the physical and psychological symptoms experienced by dialysis patients. We analyzed the latest research on the correlation between major inflammatory biomarkers released in patients’ blood due to membrane incompatibility, as well as the critical influence of low levels of hemoglobin and vital proteins such as human serum albumin due to the use of high-cut-off membranes and correlated these factors with the physical and psychological symptoms experienced by dialysis patients. Furthermore, our study aims to provide valuable insights into the impact of dialysis on critical symptoms, higher hospitalization rates, and the quality of life of First Nations, as well as child and youth dialysis patients, in addition to diabetic dialysis patients. Our goal is to identify potential interventions aiming to optimize the dialysis membrane and minimize its negative effects on patients, ultimately improving their well-being and long-term outcomes.

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Ketamine’s mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine’s antidepressant effects?

Quintanilla,

Zarate,

Pillai

2024

Mol Psychiatry

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Chronic stress and complement system in depression

Cited by 3 publications

References 8 publications

The complement system: a potential target for the comorbidity of chronic pain and depression

The complement system: a potential target for the comorbidity of chronic pain and depression

Quality of Life of Dialysis Patients: Exploring the Influence of Membrane Hemocompatibility and Dialysis Practices on Psychosocial and Physical Symptoms

Ketamine’s mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine’s antidepressant effects?

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