Biomarker potential of hsa-miR-145-5p in peripheral whole blood of manic bipolar I patients

Tekin, Sevinç; Asoğlu, Mehmet Reşit; Ay, Özlem İzci; Ay, Mustafa; Yılmaz, Şenay Görücü

doi:10.47626/1516-4446-2021-2260

Cited by 3 publications

(1 citation statement)

References 39 publications

(36 reference statements)

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“…A total of 3 of these 16 miRNAs have been previously related to the resistance to other medications. miR-145-5p (downregulated in MNR) has been linked to the acquired resistance to cisplatin and fluorouracil combination-based chemotherapy in gastric cancer patients [55] and also found to be underexpressed in patients with bipolar disorder type I when compared to healthy controls [56].…”

Section: Mirnas Potentially Related To Drug Resistancementioning

confidence: 99%

MiRNA Differences Related to Treatment-Resistant Schizophrenia

Pérez-Rodríguez

Penedo

Rivera-Baltanás

et al. 2023

IJMS

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Schizophrenia (SZ) is a serious mental disorder that is typically treated with antipsychotic medication. Treatment-resistant schizophrenia (TRS) is the condition where symptoms remain after pharmacological intervention, resulting in long-lasting functional and social impairments. As the identification and treatment of a TRS patient requires previous failed treatments, early mechanisms of detection are needed in order to quicken the access to effective therapy, as well as improve treatment adherence. In this study, we aim to find a microRNA (miRNA) signature for TRS, as well as to shed some light on the molecular pathways potentially involved in this severe condition. To do this, we compared the blood miRNAs of schizophrenia patients that respond to medication and TRS patients, thus obtaining a 16-miRNA TRS profile. Then, we assessed the ability of this signature to separate responders and TRS patients using hierarchical clustering, observing that most of them are grouped correctly (~70% accuracy). We also conducted a network, pathway analysis, and bibliography search to spot molecular pathways potentially altered in TRS. We found that the response to stress seems to be a key factor in TRS and that proteins p53, SIRT1, MDM2, and TRIM28 could be the potential mediators of such responses. Finally, we suggest a molecular pathway potentially regulated by the miRNAs of the TRS profile.

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Section: Mirnas Potentially Related To Drug Resistancementioning

confidence: 99%

MiRNA Differences Related to Treatment-Resistant Schizophrenia

Pérez-Rodríguez

Penedo

Rivera-Baltanás

et al. 2023

IJMS

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Potential of Circulating miRNAs as Molecular Markers in Mood Disorders and Associated Suicidal Behavior

Roy

Ochi

Dwivedi

2023

IJMS

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Mood disorders are the most prevalent psychiatric disorders associated with significant disability, morbidity, and mortality. The risk of suicide is associated with severe or mixed depressive episodes in patients with mood disorders. However, the risk of suicide increases with the severity of depressive episodes and is often presented with higher incidences in bipolar disorder (BD) patients than in patients with major depression (MDD). Biomarker study in neuropsychiatric disorders is critical for developing better treatment plans by facilitating more accurate diagnosis. At the same time, biomarker discovery also provides more objectivity to develop state-of-the-art personalized medicine with increased accuracy through clinical interventions. Recently, colinear changes in miRNA expression between brain and systemic circulation have added great interest in examining their potential as molecular markers in mental disorders, including MDD, BD, and suicidality. A present understanding of circulating miRNAs in body fluids implicates their role in managing neuropsychiatric conditions. Most notably, their use as prognostic and diagnostic markers and their potential role in treatment response have significantly advanced our knowledge base. The present review discusses circulatory miRNAs and their underlying possibilities to be used as a screening tool for assessing major psychiatric conditions, including MDD, BD, and suicidal behavior.

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RNA Biomarkers in Bipolar Disorder and Response to Mood Stabilizers

Pisanu

Squassina

2023

IJMS

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Bipolar disorder (BD) is a severe chronic disorder that represents one of the main causes of disability among young people. To date, no reliable biomarkers are available to inform the diagnosis of BD or clinical response to pharmacological treatment. Studies focused on coding and noncoding transcripts may provide information complementary to genome-wide association studies, allowing to correlate the dynamic evolution of different types of RNAs based on specific cell types and developmental stage with disease development or clinical course. In this narrative review, we summarize findings from human studies that evaluated the potential utility of messenger RNAs and noncoding transcripts, such as microRNAs, circular RNAs and long noncoding RNAs, as peripheral markers of BD and/or response to lithium and other mood stabilizers. The majority of available studies investigated specific targets or pathways, with large heterogeneity in the included type of cells or biofluids. However, a growing number of studies are using hypothesis-free designs, with some studies also integrating data on coding and noncoding RNAs measured in the same participants. Finally, studies conducted in neurons derived from induced-pluripotent stem cells or in brain organoids provide promising preliminary findings supporting the power and utility of these cellular models to investigate the molecular determinants of BD and clinical response.

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Biomarker potential of hsa-miR-145-5p in peripheral whole blood of manic bipolar I patients

Cited by 3 publications

References 39 publications

MiRNA Differences Related to Treatment-Resistant Schizophrenia

MiRNA Differences Related to Treatment-Resistant Schizophrenia

Potential of Circulating miRNAs as Molecular Markers in Mood Disorders and Associated Suicidal Behavior

RNA Biomarkers in Bipolar Disorder and Response to Mood Stabilizers

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